Hormonal Peptides
Peptides that interact with hormonal systems, including fertility and endocrine support.
About Hormonal Peptides
Hormonal peptides include compounds that interact with various endocrine systems. This category encompasses gonadotropin-releasing hormone (GnRH) analogs, fertility peptides, and compounds affecting thyroid, adrenal, and other hormonal pathways. Many of these peptides are FDA-approved for specific medical conditions including fertility treatments, hormone disorders, and certain cancers. They represent an important area of peptide therapeutics with established clinical applications.
All Hormonal Peptides (23)
Kisspeptin
Clinical TrialsAlso: Kisspeptin-10, Kisspeptin-54
A neuropeptide that plays a critical role in initiating puberty and regulating the reproductive hormone axis. Being studied for fertility and hormonal disorders.
MOTS-c
PreclinicalAlso: Mitochondrial ORF of the 12S rRNA type-c
A mitochondria-derived peptide that regulates metabolic homeostasis. Discovered in 2015, it's being studied for its effects on insulin sensitivity, exercise capacity, and aging.
Oxytocin
FDA ApprovedAlso: Pitocin, Syntocinon
A naturally occurring peptide hormone crucial for social bonding, childbirth, and lactation. Being studied for autism, anxiety, and social disorders.
Gonadorelin
FDA ApprovedAlso: GnRH, LHRH
A synthetic version of gonadotropin-releasing hormone. Used diagnostically and therapeutically for various reproductive and hormonal conditions.
Leuprolide
FDA ApprovedAlso: Lupron, Eligard
A GnRH agonist that suppresses testosterone and estrogen production. FDA approved for prostate cancer, endometriosis, uterine fibroids, and precocious puberty.
Desmopressin
FDA ApprovedAlso: DDAVP, Stimate
A synthetic analog of vasopressin (ADH) used for diabetes insipidus, bedwetting, and bleeding disorders. Does not cause vasoconstriction like natural vasopressin.
Octreotide
FDA ApprovedAlso: Sandostatin, Octreotide LAR
A synthetic somatostatin analog that inhibits multiple hormones. Used for acromegaly, carcinoid tumors, and various GI conditions.
Lanreotide
FDA ApprovedAlso: Somatuline, Somatuline Depot
A long-acting somatostatin analog similar to octreotide. FDA approved for acromegaly and gastroenteropancreatic neuroendocrine tumors.
Pasireotide
FDA ApprovedAlso: Signifor, Signifor LAR
A somatostatin analog with broader receptor binding than octreotide. Specifically effective for Cushing's disease due to SST5 activity.
Pegvisomant
FDA ApprovedAlso: Somavert
A GH receptor antagonist that blocks growth hormone action. Used for acromegaly when surgery and somatostatin analogs fail to normalize IGF-1.
Teriparatide
FDA ApprovedAlso: Forteo, PTH 1-34
A recombinant fragment of parathyroid hormone that stimulates bone formation. FDA approved for osteoporosis with high fracture risk.
Abaloparatide
FDA ApprovedAlso: Tymlos, BA058
A PTHrP analog that stimulates bone formation with potentially fewer side effects than teriparatide. Newer anabolic option for osteoporosis.
Insulin
FDA ApprovedAlso: Regular Insulin, Humulin
The essential peptide hormone for glucose metabolism. Multiple formulations from rapid to long-acting available for diabetes management.
Glucagon
FDA ApprovedAlso: GlucaGen, Baqsimi
A counter-regulatory hormone to insulin. FDA approved for severe hypoglycemia treatment and diagnostic procedures.
Calcitonin
FDA ApprovedAlso: Miacalcin, Fortical
A thyroid hormone that inhibits bone resorption. FDA approved for osteoporosis and Paget's disease. Also used for hypercalcemia.
Cosyntropin
FDA ApprovedAlso: Cortrosyn, ACTH 1-24
A synthetic fragment of ACTH used to diagnose adrenal insufficiency. The standard test for evaluating adrenal function.
Eptifibatide
FDA ApprovedAlso: Integrilin
A cyclic peptide that inhibits platelet aggregation. Used during coronary interventions to prevent clot formation.
Bivalirudin
FDA ApprovedAlso: Angiomax, Angiox
A synthetic direct thrombin inhibitor derived from hirudin. Used as an anticoagulant during PCI procedures.
Follistatin
Clinical TrialsAlso: FST, FS344
A naturally occurring protein that inhibits myostatin. Studied for muscle growth and dystrophy conditions.
ACE-031
PreclinicalAlso: ACVR2B-Fc, Myostatin Inhibitor
A soluble activin receptor that traps myostatin. Developed for muscular dystrophy but trials halted due to safety concerns.
Macimorelin
FDA ApprovedAlso: Macrilen, AEZS-130
An oral ghrelin mimetic used to diagnose adult growth hormone deficiency. The first FDA-approved oral GH stimulation test.
Linaclotide
FDA ApprovedAlso: Linzess, Constella
A peptide guanylate cyclase-C agonist for IBS-C and chronic constipation. Works locally in the gut with minimal systemic absorption.
Plecanatide
FDA ApprovedAlso: Trulance
A uroguanylin analog for chronic constipation and IBS-C. Similar to linaclotide but designed to mimic an endogenous peptide.
Frequently Asked Questions About Hormonal Peptides
What are hormonal peptides?
Hormonal peptides are compounds that interact with the endocrine system. They include fertility medications, hormone analogs, and compounds that affect thyroid, adrenal, and reproductive hormones. Many are FDA-approved for specific medical conditions.
Are hormonal peptides used in fertility treatment?
Yes, several hormonal peptides are FDA-approved for fertility treatment. These include GnRH agonists and antagonists used in IVF protocols, as well as gonadotropins that stimulate egg or sperm production.
Do hormonal peptides require a prescription?
Most hormonal peptides are prescription medications due to their significant effects on the endocrine system. They should only be used under medical supervision due to potential effects on hormone balance.
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Educational Information Only
This information about hormonal peptides is for educational purposes only and does not constitute medical advice. Always consult qualified healthcare providers before making decisions about peptides or supplements.