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Hormonal

Cosyntropin

Also known as: Cortrosyn, ACTH 1-24, Tetracosactide

FDA Approved
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Key Facts: Cosyntropin

Category
Hormonal
FDA Status
FDA Approved
Clinical Status
FDA Approved - Diagnostic use
Administration
IV or intramuscular
Typical Dose
Limited community data available
Frequency
See research protocols
Evidence Level
FDA Approved
Duration
Single diagnostic dose
Also Known As
Cortrosyn, ACTH 1-24, Tetracosactide

What to Expect

A synthetic fragment of ACTH used to diagnose adrenal insufficiency. The standard test for evaluating adrenal function.

Mechanism of Action

Cosyntropin contains the first 24 amino acids of ACTH, which is all that's needed for biological activity. It stimulates cortisol release from the adrenal glands, allowing assessment of adrenal reserve.

Research Summary

Gold standard for adrenal insufficiency diagnosis since the 1970s. More stable than full-length ACTH. Low-dose (1 mcg) protocol may be more sensitive for detecting secondary insufficiency.

Clinical Status:FDA Approved - Diagnostic use
Trial Progress:FDA Approved
Pre
I
II
III
IV
FDA

Dosing Information

FDA Approved·Human clinical trials completed, FDA approved

Typical Dosingⓘ

Community experience

Common Dose

Limited community data available

Range

See research dosing

Frequency

See research protocols

Research Dosingⓘ

Scientific studies

Standard diagnostic protocols

Doses from Studies

Duration

Single diagnostic dose

Administration

IV or intramuscular

Timing & Administration

Best Time to Take

Morning or as directed

Follow recommended protocol

Food Recommendation

With or without food

Why This Timing?

Timing may vary based on individual response and goals. Consistency is generally more important than specific timing.

Possible Side Effects

Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.

  • ●Hypersensitivity reactions (common)
  • ●Injection site reactions
  • ●Bradycardia or tachycardia
  • ●Blood pressure changes
  • ●Headache
  • ●Intended for diagnostic use
  • ●FDA approved (Cortrosyn)

References

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Educational Information Only

This information is provided for educational purposes only and is not intended as medical advice. Always consult with qualified healthcare providers before making any decisions about peptides or other substances. The protocols listed reflect doses observed in research studies, not recommendations.

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