Cosyntropin
Also known as: Cortrosyn, ACTH 1-24, Tetracosactide
Key Facts: Cosyntropin
- Category
- Hormonal
- FDA Status
- FDA Approved
- Clinical Status
- FDA Approved - Diagnostic use
- Administration
- IV or intramuscular
- Typical Dose
- Limited community data available
- Frequency
- See research protocols
- Duration
- Single diagnostic dose
Mechanism of Action
Cosyntropin contains the first 24 amino acids of ACTH, which is all that is needed for biological activity. It stimulates cortisol release from the adrenal glands, allowing assessment of adrenal reserve.
Research Summary
Gold standard for adrenal insufficiency diagnosis since the 1970s. More stable than full-length ACTH. Low-dose (1 mcg) protocol may be more sensitive for detecting secondary insufficiency.
Dosing Information
Typical Dosingⓘ
Community experience
Limited community data available
See research dosing
See research protocols
Research Dosingⓘ
Scientific studies
Standard diagnostic protocols
Doses from Studies
250 mcg IV/IM (standard)
1 mcg IV (low-dose)
Duration
Single diagnostic dose
Administration
IV or intramuscular
Timing & Administration
Best Time to Take
Morning or as directed
Follow recommended protocol
Food Recommendation
With or without food
Why This Timing?
Timing may vary based on individual response and goals. Consistency is generally more important than specific timing.
Possible Side Effects
Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.
- ●Hypersensitivity reactions (common)
- ●Injection site reactions
- ●Bradycardia or tachycardia
- ●Blood pressure changes
- ●Headache
- ●Intended for diagnostic use
- ●FDA approved (Cortrosyn)
References
- https://pubmed.ncbi.nlm.nih.gov/8772681/
- https://pubmed.ncbi.nlm.nih.gov/16533018/
- https://pubmed.ncbi.nlm.nih.gov/28324084/
Research This Peptide Further
Frequently Asked Questions
What does Cosyntropin do?
A synthetic fragment of ACTH used to diagnose adrenal insufficiency. The standard test for evaluating adrenal function.
How does Cosyntropin work?
Cosyntropin contains the first 24 amino acids of ACTH, which is all that is needed for biological activity. It stimulates cortisol release from the adrenal glands, allowing assessment of adrenal reserve.
Is Cosyntropin FDA approved?
Yes, Cosyntropin is FDA approved. FDA Approved - Diagnostic use
What are the side effects of Cosyntropin?
Reported side effects include: Hypersensitivity reactions (common), Injection site reactions, Bradycardia or tachycardia, Blood pressure changes, Headache. Individual responses vary based on dosage, duration, and personal health factors.
What is the typical dose of Cosyntropin?
Community-reported common dose: Limited community data available (See research protocols). Range: See research dosing. Administration: IV or intramuscular. Community-reported doses. Not medical advice. Consult healthcare provider.
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