MOTS-c
Also known as: Mitochondrial ORF of the 12S rRNA type-c
Key Facts: MOTS-c
- Category
- Hormonal
- FDA Status
- Not FDA Approved
- Clinical Status
- Preclinical - Early human studies beginning
- Administration
- Subcutaneous injection
- Typical Dose
- 5-10 mg weekly
- Frequency
- 1-3x weekly
- Evidence Level
- Animal Studies
- Duration
- Variable by protocol
What to Expect
A mitochondria-derived peptide that regulates metabolic homeostasis. Discovered in 2015, it's being studied for its effects on insulin sensitivity, exercise capacity, and aging.
Mechanism of Action
MOTS-c is encoded by mitochondrial DNA and acts as a mitokine, communicating mitochondrial status to the rest of the body. It activates AMPK, improves glucose uptake, enhances fatty acid oxidation, and has systemic metabolic regulatory effects.
Research Summary
Studies show MOTS-c improves insulin sensitivity and prevents diet-induced obesity in mice. Research demonstrates enhanced exercise capacity and protection against age-related metabolic decline. Human studies are limited but promising.
Dosing Information
Note: Animal study doses may not translate directly to humans.
Typical Dosingⓘ
Community experience
5-10 mg weekly
5-15 mg per week
1-3x weekly
Mitochondrial peptide for metabolic health. Take on exercise days. Often used 2-3x weekly.
Research Dosingⓘ
Scientific studies
Doses from research protocols
Doses from Studies
Research doses varied significantly
Duration
Variable by protocol
Administration
Subcutaneous injection
Timing & Administration
Best Time to Take
Morning or pre-workout
3-5 times per week
Food Recommendation
Take on empty stomach
Why This Timing?
MOTS-c enhances metabolic function and exercise capacity. Morning/pre-exercise timing optimizes benefits.
Possible Side Effects
Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.
- ●Generally well-tolerated
- ●Injection site reactions (persistent bumps)
- ●Palpitations
- ●Nausea and bloating
- ●Fatigue
- ●May trigger histamine release - use caution with MCAS or histamine sensitivity
- ●Potential interactions with metformin
- ●Long-term effects unknown
References
Related Peptides
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Educational Information Only
This information is provided for educational purposes only and is not intended as medical advice. Always consult with qualified healthcare providers before making any decisions about peptides or other substances. The protocols listed reflect doses observed in research studies, not recommendations.