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Hormonal

Eptifibatide

Also known as: Integrilin

FDA Approved
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Key Facts: Eptifibatide

Category
Hormonal
FDA Status
FDA Approved
Clinical Status
FDA Approved - Acute coronary syndrome and PCI
Banned in Sport (WADA)
Not on the WADA Prohibited List (2026).
Administration
IV bolus and infusion
Typical Dose
Limited community data available
Frequency
See research protocols
Duration
Up to 72 hours
Also Known As
Integrilin

How does Eptifibatide work?

Platelets stick together by linking their glycoprotein IIb/IIIa receptors to fibrinogen, the final common step that builds a blood clot. Eptifibatide is a competitive antagonist that plugs the IIb/IIIa receptor using a KGD (Lys-Gly-Asp) recognition sequence, so fibrinogen cannot bridge one platelet to the next and aggregation grinds to a halt. The molecule binds reversibly and clears quickly, with a plasma half-life of roughly 2.5 hours, so platelet function recovers within hours of stopping the infusion. That fast on, fast off behavior is exactly what you want in a hospital setting where bleeding risk has to be controlled.

What does the research show?

Eptifibatide is backed by large randomized human trials, not preliminary data. The PURSUIT trial published in the New England Journal of Medicine in 1998 enrolled over 10,000 patients with acute coronary syndromes without ST elevation and found eptifibatide reduced the combined rate of death or nonfatal myocardial infarction compared with placebo. The ESPRIT trial showed that a two-bolus plus infusion regimen during stenting cut the 30-day rate of death, MI, or urgent revascularization from about 10.4 percent to 6.8 percent versus placebo. Across these trials the main trade-off is bleeding, and unlike some older agents eptifibatide was not found to be immunogenic or to commonly cause thrombocytopenia. Its pharmacology is well characterized, with a short half-life that makes the antiplatelet effect rapidly reversible. In short, this is a mature, evidence-based drug whose benefits and risks in cardiac care are clearly established.

Trial Progress:FDA Approved
Pre
I
II
III
IV
FDA

What doses have been studied?

FDA Approved·Human clinical trials completed, FDA approved

Typical Dosingⓘ

Community experience

Common Dose

Limited community data available

Range

See research dosing

Frequency

See research protocols

Research Dosingⓘ

Scientific studies

Hospital/procedural use

Doses from Studies

Duration

Up to 72 hours

Administration

IV bolus and infusion

When and how is Eptifibatide taken?

Best Time to Take

Morning or as directed

Follow recommended protocol

Food Recommendation

With or without food

Why This Timing?

Timing may vary based on individual response and goals. Consistency is generally more important than specific timing.

What are the side effects of Eptifibatide?

Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.

  • ●Bleeding (28% - most common)
  • ●Major bleeding (3-10%)
  • ●Hypotension
  • ●Thrombocytopenia
  • ●Allergic reactions
  • ●High-risk medication per ISMP

References

Research This Peptide Further

Frequently Asked Questions

What does Eptifibatide do?

Eptifibatide is an FDA-approved intravenous antiplatelet drug, sold as Integrilin, and it has an oddly cool origin: it is a synthetic cyclic heptapeptide modeled on barbourin, a protein from the venom of the southeastern pygmy rattlesnake. It is used in hospitals during acute coronary syndromes and percutaneous coronary intervention (PCI, the stent procedure) to stop platelets from clumping and forming dangerous clots. This is a real, approved cardiac drug, not a wellness or research peptide.

How does Eptifibatide work?

Platelets stick together by linking their glycoprotein IIb/IIIa receptors to fibrinogen, the final common step that builds a blood clot. Eptifibatide is a competitive antagonist that plugs the IIb/IIIa receptor using a KGD (Lys-Gly-Asp) recognition sequence, so fibrinogen cannot bridge one platelet to the next and aggregation grinds to a halt. The molecule binds reversibly and clears quickly, with a plasma half-life of roughly 2.5 hours, so platelet function recovers within hours of stopping the infusion. That fast on, fast off behavior is exactly what you want in a hospital setting where bleeding risk has to be controlled.

Is Eptifibatide FDA approved?

Yes, Eptifibatide is FDA approved. FDA Approved - Acute coronary syndrome and PCI

Is Eptifibatide banned in sport?

Not on the WADA Prohibited List (2026).

What are the side effects of Eptifibatide?

Reported side effects include: Bleeding (28% - most common), Major bleeding (3-10%), Hypotension, Thrombocytopenia, Allergic reactions. Individual responses vary based on dosage, duration, and personal health factors.

What is the typical dose of Eptifibatide?

Community-reported common dose: Limited community data available (See research protocols). Range: See research dosing. Administration: IV bolus and infusion. Prescription drug. Dose set by prescriber per label. Not medical advice.

Related Peptides

Peptides commonly compared with Eptifibatide or used in similar applications.

HCG (Human Chorionic Gonadotropin)

FDA

HCG is a hormone produced in pregnancy that happens to be an almost perfect mimic of luteinizing hormone. That single fact is why it has two completely unrelated uses: it is an approved fertility medicine, and it is the standard tool for keeping the testicles working during testosterone therapy. It is also the basis of the discredited HCG diet, which is a separate story and not supported by evidence.

Hormonal

Oxytocin

FDA

Oxytocin is a 9-amino-acid hormone made in the hypothalamus, famous as the chemistry behind labor contractions, breastfeeding, and social bonding. As an injectable drug it is FDA-approved to induce labor and control postpartum bleeding, but the intranasal 'love hormone' versions sold for trust, anxiety, and autism are experimental and the human results are genuinely mixed. The hype runs well ahead of the evidence.

Hormonal

Leuprolide

FDA

Leuprolide (brand name Lupron) is a synthetic GnRH agonist, a modified peptide far more potent than natural GnRH, and it is FDA-approved for advanced prostate cancer, endometriosis, uterine fibroids, and central precocious puberty. The clever part is counterintuitive: it works by overstimulating the GnRH system so hard that the pituitary shuts down sex hormone production. It is a real, long-established prescription drug (first US approval 1985), not a research peptide, and it carries meaningful side effects from the low-hormone state it creates.

Hormonal

Desmopressin

FDA

Desmopressin (dDAVP) is a synthetic tweak of the natural hormone vasopressin, redesigned to keep the water-retaining effect while dropping most of the blood-pressure effect. First approved in the US in 1978, it is used for central diabetes insipidus, bedwetting, nocturia, and two bleeding disorders: hemophilia A and type 1 von Willebrand disease. This is settled medicine, not an experimental peptide, and its main real-world danger is straightforward: it can drop your blood sodium dangerously low if you drink too much fluid on it.

Hormonal

Octreotide

FDA

Octreotide is a synthetic eight-amino-acid mimic of the natural hormone somatostatin, the body's main 'off switch' for hormone secretion. It shuts down excess growth hormone, so it is a frontline FDA-approved drug for acromegaly, and it also tames the flushing and diarrhea of hormone-secreting carcinoid and other neuroendocrine tumors. This is real, approved medicine with decades of clinical data behind it, sold as Sandostatin (injectable, since 1988), Sandostatin LAR (monthly depot), and Mycapssa (oral capsule, approved 2020).

Hormonal

Lanreotide

FDA

Lanreotide (development code BIM-23014) is an eight-amino-acid somatostatin analog, a close cousin of octreotide, given as a long-acting deep-injection gel (Somatuline Depot/Autogel) usually once a month. The FDA approved it for acromegaly in 2007, for gastroenteropancreatic neuroendocrine tumors in 2014, and for carcinoid syndrome in 2017. Generic versions now exist alongside Ipsen's Somatuline Depot. It is established prescription medicine, not an experimental compound.

Hormonal

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