Peptibase
Hormonal

Eptifibatide

Also known as: Integrilin

FDA Approved
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Key Facts: Eptifibatide

Category
Hormonal
FDA Status
FDA Approved
Clinical Status
FDA Approved - Acute coronary syndrome and PCI
Administration
IV bolus and infusion
Typical Dose
Limited community data available
Frequency
See research protocols
Evidence Level
FDA Approved
Duration
Up to 72 hours
Also Known As
Integrilin

What to Expect

A cyclic peptide that inhibits platelet aggregation. Used during coronary interventions to prevent clot formation.

Mechanism of Action

Eptifibatide is an RGD-mimetic that blocks the glycoprotein IIb/IIIa receptor on platelets, preventing fibrinogen binding and platelet aggregation. Derived from a protein in pygmy rattlesnake venom.

Research Summary

PURSUIT and ESPRIT trials showed reduced cardiac events in ACS and PCI patients. Shorter half-life than abciximab allows faster platelet recovery. Part of standard ACS treatment protocols.

Clinical Status:FDA Approved - Acute coronary syndrome and PCI
Trial Progress:FDA Approved
Pre
I
II
III
IV
FDA

Dosing Information

FDA Approved·Human clinical trials completed, FDA approved

Typical Dosingⓘ

Community experience

Common Dose

Limited community data available

Range

See research dosing

Frequency

See research protocols

Research Dosingⓘ

Scientific studies

Hospital/procedural use

Doses from Studies

2 mcg/kg/min infusion up to 72 hours

FDA Approved Labeling - Prescribed dose ↗

Duration

Up to 72 hours

Administration

IV bolus and infusion

Timing & Administration

Best Time to Take

Morning or as directed

Follow recommended protocol

Food Recommendation

With or without food

Why This Timing?

Timing may vary based on individual response and goals. Consistency is generally more important than specific timing.

Possible Side Effects

Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.

  • ●Bleeding (28% - most common)
  • ●Major bleeding (3-10%)
  • ●Hypotension
  • ●Thrombocytopenia
  • ●Allergic reactions
  • ●High-risk medication per ISMP
  • ●FDA approved (Integrilin)

References

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Educational Information Only

This information is provided for educational purposes only and is not intended as medical advice. Always consult with qualified healthcare providers before making any decisions about peptides or other substances. The protocols listed reflect doses observed in research studies, not recommendations.

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