Peptibase
Hormonal

Linaclotide

Also known as: Linzess, Constella

FDA Approved
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Key Facts: Linaclotide

Category
Hormonal
FDA Status
FDA Approved
Clinical Status
FDA Approved - IBS-C and chronic constipation
Administration
Oral capsule on empty stomach
Typical Dose
Limited community data available
Frequency
See research protocols
Evidence Level
FDA Approved
Duration
Long-term / chronic use
Also Known As
Linzess, Constella

What to Expect

A peptide guanylate cyclase-C agonist for IBS-C and chronic constipation. Works locally in the gut with minimal systemic absorption.

Mechanism of Action

Linaclotide activates guanylate cyclase-C on intestinal epithelium, increasing cGMP which leads to chloride and water secretion into the intestines. Also reduces visceral pain signaling.

Research Summary

Multiple trials showed improvement in bowel movements and abdominal pain in IBS-C. Works within the first week. Also effective for chronic idiopathic constipation.

Clinical Status:FDA Approved - IBS-C and chronic constipation
Trial Progress:FDA Approved
Pre
I
II
III
IV
FDA

Dosing Information

FDA Approved·Human clinical trials completed, FDA approved

Typical Dosingⓘ

Community experience

Common Dose

Limited community data available

Range

See research dosing

Frequency

See research protocols

Research Dosingⓘ

Scientific studies

FDA-approved dosing

Duration

Long-term / chronic use

Administration

Oral capsule on empty stomach

Timing & Administration

Best Time to Take

Morning or as directed

Follow recommended protocol

Food Recommendation

With or without food

Why This Timing?

Timing may vary based on individual response and goals. Consistency is generally more important than specific timing.

Possible Side Effects

Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.

  • ●Diarrhea (up to 50%)
  • ●Abdominal pain
  • ●Flatulence
  • ●Fecal incontinence
  • ●CONTRAINDICATED in children <2 years
  • ●FDA approved (Linzess)

References

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Educational Information Only

This information is provided for educational purposes only and is not intended as medical advice. Always consult with qualified healthcare providers before making any decisions about peptides or other substances. The protocols listed reflect doses observed in research studies, not recommendations.

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