Gonadorelin
Also known as: GnRH, LHRH, Factrel
Key Facts: Gonadorelin
- Category
- Hormonal
- FDA Status
- FDA Approved
- Clinical Status
- FDA Approved - Diagnostic and therapeutic uses
- Administration
- IV, subcutaneous, or pulsatile pump
- Typical Dose
- 100-500 mcg 2-3x weekly
- Frequency
- 2-3x weekly
- Evidence Level
- FDA Approved
- Duration
- Single dose (diagnostic) or ongoing (therapeutic)
What to Expect
A synthetic version of gonadotropin-releasing hormone. Used diagnostically and therapeutically for various reproductive and hormonal conditions.
Mechanism of Action
Gonadorelin stimulates the pituitary to release LH and FSH. Pulsatile administration supports natural hormone production, while continuous administration causes desensitization and hormone suppression. Effects depend entirely on dosing pattern.
Research Summary
FDA approved for diagnostic testing of pituitary function. Used to stimulate testosterone production when given in pulses. Continuous use leads to chemical castration effect used in prostate cancer and endometriosis.
Dosing Information
Typical Dosingⓘ
Community experience
100-500 mcg 2-3x weekly
50-500 mcg per dose
2-3x weekly
GnRH analog for maintaining testosterone during TRT. Often dosed with HCG protocols.
Research Dosingⓘ
Scientific studies
Varies by indication
Doses from Studies
100 mcg IV/SC for diagnostic testing
Pulsatile: varies by protocol
Duration
Single dose (diagnostic) or ongoing (therapeutic)
Administration
IV, subcutaneous, or pulsatile pump
Timing & Administration
Best Time to Take
Morning or as clinically directed
As prescribed, often pulsatile
Food Recommendation
With or without food
Why This Timing?
GnRH analog used for hormone stimulation. Timing depends on specific clinical protocol.
Possible Side Effects
Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.
- ●Injection site reactions
- ●Headache
- ●Flushing
- ●Nausea
- ●Risk of multiple births
- ●May worsen hormone-dependent cancers
- ●Long-term: bone density decrease
References
Related Peptides
Peptides commonly compared with Gonadorelin or used in similar applications.
Lanreotide
FDAA long-acting somatostatin analog similar to octreotide. FDA approved for acromegaly and gastroenteropancreatic neuroendocrine tumors.
HormonalPegvisomant
FDAA GH receptor antagonist that blocks growth hormone action. Used for acromegaly when surgery and somatostatin analogs fail to normalize IGF-1.
HormonalMacimorelin
FDAAn oral ghrelin mimetic used to diagnose adult growth hormone deficiency. The first FDA-approved oral GH stimulation test.
HormonalOxytocin
FDAA naturally occurring peptide hormone crucial for social bonding, childbirth, and lactation. Being studied for autism, anxiety, and social disorders.
HormonalLeuprolide
FDAA GnRH agonist that suppresses testosterone and estrogen production. FDA approved for prostate cancer, endometriosis, uterine fibroids, and precocious puberty.
HormonalDesmopressin
FDAA synthetic analog of vasopressin (ADH) used for diabetes insipidus, bedwetting, and bleeding disorders. Does not cause vasoconstriction like natural vasopressin.
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Educational Information Only
This information is provided for educational purposes only and is not intended as medical advice. Always consult with qualified healthcare providers before making any decisions about peptides or other substances. The protocols listed reflect doses observed in research studies, not recommendations.