Lanreotide
Also known as: Somatuline, Somatuline Depot
Key Facts: Lanreotide
- Category
- Hormonal
- FDA Status
- FDA Approved
- Clinical Status
- FDA Approved - Acromegaly and GEP-NETs
- Administration
- Deep subcutaneous injection
- Typical Dose
- 60-120 mg every 4 weeks
- Frequency
- Every 4 weeks (deep SC)
- Duration
- Long-term / chronic use
Mechanism of Action
Lanreotide binds preferentially to SST2 and SST5 somatostatin receptors. Inhibits GH secretion, reduces IGF-1 levels, and has antiproliferative effects on neuroendocrine tumor cells. Self-injectable deep SC formulation.
Research Summary
CLARINET trial demonstrated tumor control in GEP-NETs. Noninferior to octreotide for acromegaly. Unique self-injectable deep subcutaneous formulation improves convenience. Extended dosing interval available.
Dosing Information
Typical Dosingⓘ
Community experience
60-120 mg every 4 weeks
60-120 mg per injection
Every 4 weeks (deep SC)
Long-acting somatostatin analog. Somatuline Depot. Deep subcutaneous injection.
Research Dosingⓘ
Scientific studies
FDA-approved dosing
Doses from Studies
60-120 mg deep SC every 4 weeks
Extended interval dosing possible
Duration
Long-term / chronic use
Administration
Deep subcutaneous injection
Timing & Administration
Best Time to Take
Morning or as directed
Follow recommended protocol
Food Recommendation
With or without food
Why This Timing?
Timing may vary based on individual response and goals. Consistency is generally more important than specific timing.
Possible Side Effects
Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.
- ●Diarrhea
- ●Abdominal pain
- ●Nausea
- ●Injection site reactions
- ●Gallstones
- ●Hyperglycemia or hypoglycemia
- ●Bradycardia
- ●FDA approved (Somatuline)
References
- https://pubmed.ncbi.nlm.nih.gov/25014687/
- https://pubmed.ncbi.nlm.nih.gov/26743120/
- https://pubmed.ncbi.nlm.nih.gov/33052555/
Research This Peptide Further
Frequently Asked Questions
What does Lanreotide do?
A long-acting somatostatin analog similar to octreotide. FDA approved for acromegaly and gastroenteropancreatic neuroendocrine tumors.
How does Lanreotide work?
Lanreotide binds preferentially to SST2 and SST5 somatostatin receptors. Inhibits GH secretion, reduces IGF-1 levels, and has antiproliferative effects on neuroendocrine tumor cells. Self-injectable deep SC formulation.
Is Lanreotide FDA approved?
Yes, Lanreotide is FDA approved. FDA Approved - Acromegaly and GEP-NETs
What are the side effects of Lanreotide?
Reported side effects include: Diarrhea, Abdominal pain, Nausea, Injection site reactions, Gallstones. Individual responses vary based on dosage, duration, and personal health factors.
What is the typical dose of Lanreotide?
Community-reported common dose: 60-120 mg every 4 weeks (Every 4 weeks (deep SC)). Range: 60-120 mg per injection. Administration: Deep subcutaneous injection. Community-reported doses. Not medical advice. Consult healthcare provider.
Related Peptides
Peptides commonly compared with Lanreotide or used in similar applications.
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FDAA synthetic version of gonadotropin-releasing hormone. Used diagnostically and therapeutically for various reproductive and hormonal conditions.
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HormonalDesmopressin
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