Peptibase
Hormonal

Bivalirudin

Also known as: Angiomax, Angiox

FDA Approved
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Key Facts: Bivalirudin

Category
Hormonal
FDA Status
FDA Approved
Clinical Status
FDA Approved - PCI anticoagulation
Administration
IV bolus and infusion
Typical Dose
Limited community data available
Frequency
See research protocols
Evidence Level
FDA Approved
Duration
Duration of procedure
Also Known As
Angiomax, Angiox

What to Expect

A synthetic direct thrombin inhibitor derived from hirudin. Used as an anticoagulant during PCI procedures.

Mechanism of Action

Bivalirudin directly inhibits thrombin by binding to both its active site and exosite 1. Unlike heparin, it inhibits both free and clot-bound thrombin. Predictable anticoagulation without need for antithrombin.

Research Summary

HORIZONS-AMI and other trials established efficacy in PCI. Lower bleeding risk than heparin plus GP IIb/IIIa inhibitors in many settings. Short half-life allows rapid offset.

Clinical Status:FDA Approved - PCI anticoagulation
Trial Progress:FDA Approved
Pre
I
II
III
IV
FDA

Dosing Information

FDA Approved·Human clinical trials completed, FDA approved

Typical Dosingⓘ

Community experience

Common Dose

Limited community data available

Range

See research dosing

Frequency

See research protocols

Research Dosingⓘ

Scientific studies

Procedural use

Doses from Studies

1.75 mg/kg/h infusion during procedure

FDA Approved Labeling - Prescribed dose ↗

Duration

Duration of procedure

Administration

IV bolus and infusion

Timing & Administration

Best Time to Take

Morning or as directed

Follow recommended protocol

Food Recommendation

With or without food

Why This Timing?

Timing may vary based on individual response and goals. Consistency is generally more important than specific timing.

Possible Side Effects

Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.

  • ●Bleeding (28%)
  • ●Headache
  • ●Thrombocytopenia
  • ●Hypotension
  • ●Acute stent thrombosis (higher than heparin)
  • ●Allergic reactions
  • ●FDA approved (Angiomax)

References

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Educational Information Only

This information is provided for educational purposes only and is not intended as medical advice. Always consult with qualified healthcare providers before making any decisions about peptides or other substances. The protocols listed reflect doses observed in research studies, not recommendations.

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