Plecanatide
Also known as: Trulance
Key Facts: Plecanatide
- Category
- Hormonal
- FDA Status
- FDA Approved
- Clinical Status
- FDA Approved - CIC and IBS-C
- Administration
- Oral tablet with or without food
- Typical Dose
- Limited community data available
- Frequency
- See research protocols
- Duration
- Long-term / chronic use
Mechanism of Action
Plecanatide is structurally similar to human uroguanylin and activates guanylate cyclase-C. pH-sensitive activation may provide more targeted action in the small intestine.
Research Summary
Clinical trials showed significant improvement in spontaneous bowel movements and IBS symptoms. May have lower diarrhea rates than linaclotide due to pH-dependent activation.
Dosing Information
Typical Dosingⓘ
Community experience
Limited community data available
See research dosing
See research protocols
Research Dosingⓘ
Scientific studies
FDA-approved dosing
Doses from Studies
3 mg once daily
Duration
Long-term / chronic use
Administration
Oral tablet with or without food
Timing & Administration
Best Time to Take
Morning or as directed
Follow recommended protocol
Food Recommendation
With or without food
Why This Timing?
Timing may vary based on individual response and goals. Consistency is generally more important than specific timing.
Possible Side Effects
Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.
- ●Diarrhea (4-5%)
- ●Nausea
- ●CONTRAINDICATED in children <6 years
- ●FDA approved (Trulance)
References
- https://pubmed.ncbi.nlm.nih.gov/28134631/
- https://pubmed.ncbi.nlm.nih.gov/29081034/
- https://pubmed.ncbi.nlm.nih.gov/30145888/
Research This Peptide Further
Frequently Asked Questions
What does Plecanatide do?
A uroguanylin analog for chronic constipation and IBS-C. Similar to linaclotide but designed to mimic an endogenous peptide.
How does Plecanatide work?
Plecanatide is structurally similar to human uroguanylin and activates guanylate cyclase-C. pH-sensitive activation may provide more targeted action in the small intestine.
Is Plecanatide FDA approved?
Yes, Plecanatide is FDA approved. FDA Approved - CIC and IBS-C
What are the side effects of Plecanatide?
Reported side effects include: Diarrhea (4-5%), Nausea, CONTRAINDICATED in children <6 years, FDA approved (Trulance). Individual responses vary based on dosage, duration, and personal health factors.
What is the typical dose of Plecanatide?
Community-reported common dose: Limited community data available (See research protocols). Range: See research dosing. Administration: Oral tablet with or without food. Community-reported doses. Not medical advice. Consult healthcare provider.
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