Plecanatide
Also known as: Trulance
Key Facts: Plecanatide
- Category
- Hormonal
- FDA Status
- FDA Approved
- Clinical Status
- FDA Approved - CIC and IBS-C
- Administration
- Oral tablet with or without food
- Typical Dose
- Limited community data available
- Frequency
- See research protocols
- Evidence Level
- FDA Approved
- Duration
- Long-term / chronic use
What to Expect
A uroguanylin analog for chronic constipation and IBS-C. Similar to linaclotide but designed to mimic an endogenous peptide.
Mechanism of Action
Plecanatide is structurally similar to human uroguanylin and activates guanylate cyclase-C. pH-sensitive activation may provide more targeted action in the small intestine.
Research Summary
Clinical trials showed significant improvement in spontaneous bowel movements and IBS symptoms. May have lower diarrhea rates than linaclotide due to pH-dependent activation.
Dosing Information
Typical Dosingⓘ
Community experience
Limited community data available
See research dosing
See research protocols
Research Dosingⓘ
Scientific studies
FDA-approved dosing
Doses from Studies
3 mg once daily
Duration
Long-term / chronic use
Administration
Oral tablet with or without food
Timing & Administration
Best Time to Take
Morning or as directed
Follow recommended protocol
Food Recommendation
With or without food
Why This Timing?
Timing may vary based on individual response and goals. Consistency is generally more important than specific timing.
Possible Side Effects
Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.
- ●Diarrhea (4-5%)
- ●Nausea
- ●CONTRAINDICATED in children <6 years
- ●FDA approved (Trulance)
References
Related Peptides
Peptides commonly compared with Plecanatide or used in similar applications.
Oxytocin
FDAA naturally occurring peptide hormone crucial for social bonding, childbirth, and lactation. Being studied for autism, anxiety, and social disorders.
HormonalGonadorelin
FDAA synthetic version of gonadotropin-releasing hormone. Used diagnostically and therapeutically for various reproductive and hormonal conditions.
HormonalLeuprolide
FDAA GnRH agonist that suppresses testosterone and estrogen production. FDA approved for prostate cancer, endometriosis, uterine fibroids, and precocious puberty.
HormonalDesmopressin
FDAA synthetic analog of vasopressin (ADH) used for diabetes insipidus, bedwetting, and bleeding disorders. Does not cause vasoconstriction like natural vasopressin.
HormonalOctreotide
FDAA synthetic somatostatin analog that inhibits multiple hormones. Used for acromegaly, carcinoid tumors, and various GI conditions.
HormonalLanreotide
FDAA long-acting somatostatin analog similar to octreotide. FDA approved for acromegaly and gastroenteropancreatic neuroendocrine tumors.
HormonalWant updates on Plecanatide research?
Subscribe to get notified when we add new research findings, protocol updates, and related peptide information.
Educational Information Only
This information is provided for educational purposes only and is not intended as medical advice. Always consult with qualified healthcare providers before making any decisions about peptides or other substances. The protocols listed reflect doses observed in research studies, not recommendations.