Peptibase
Hormonal

Abaloparatide

Also known as: Tymlos, BA058

FDA Approved
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Popular For

Osteoporosis, bone health, fracture risk reduction

Key Facts: Abaloparatide

Category
Hormonal
FDA Status
FDA Approved
Clinical Status
FDA Approved - Postmenopausal osteoporosis
Administration
Subcutaneous injection daily
Typical Dose
80 mcg daily
Frequency
Once daily
Evidence Level
FDA Approved
Duration
Maximum 2 years (same lifetime limit as teriparatide)
Also Known As
Tymlos, BA058

Mechanism of Action

Abaloparatide is an analog of PTH-related protein (PTHrP). It preferentially binds to the RG conformation of PTH1 receptor, favoring anabolic signaling over bone resorption. Results in bone building with less hypercalcemia.

Research Summary

ACTIVE trial showed superior reduction in vertebral and non-vertebral fractures vs placebo. Comparative data suggests similar or better efficacy than teriparatide with less hypercalcemia. Second anabolic osteoporosis drug approved.

Clinical Status:FDA Approved - Postmenopausal osteoporosis
Trial Progress:FDA Approved
Pre
I
II
III
IV
FDA

Dosing Information

FDA Approved·Human clinical trials completed, FDA approved

Typical Dosingⓘ

Community experience

Common Dose

80 mcg daily

Range

80 mcg daily

Frequency

Once daily

PTHrP analog for osteoporosis. Similar to teriparatide but different binding profile.

Research Dosingⓘ

Scientific studies

FDA-approved dosing

Doses from Studies

Duration

Maximum 2 years (same lifetime limit as teriparatide)

Administration

Subcutaneous injection daily

Timing & Administration

Best Time to Take

Morning or as directed

Follow recommended protocol

Food Recommendation

With or without food

Why This Timing?

Timing may vary based on individual response and goals. Consistency is generally more important than specific timing.

Possible Side Effects

Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.

  • ●Hypercalciuria (11%)
  • ●Dizziness (10%)
  • ●Nausea (8%)
  • ●Palpitations (5%)
  • ●Injection site reactions
  • ●Orthostatic hypotension
  • ●Osteosarcoma risk in rats
  • ●FDA approved (Tymlos)

References

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