Abaloparatide
Also known as: Tymlos, BA058
Key Facts: Abaloparatide
- Category
- Hormonal
- FDA Status
- FDA Approved
- Clinical Status
- FDA Approved - Osteoporosis in postmenopausal women and men at high risk for fracture (male indication added Dec 2022)
- Banned in Sport (WADA)
- Not on the WADA Prohibited List (2026).
- Administration
- Subcutaneous injection daily
- Typical Dose
- 80 mcg daily
- Frequency
- Once daily
- Duration
- Maximum 2 years (same lifetime limit as teriparatide)
How does Abaloparatide work?
Abaloparatide hits the same target as teriparatide, the PTH type 1 receptor (PTHR1), but it was engineered to favor a specific receptor conformation (the RG-bound state) that produces a more transient signal. The idea, supported by preclinical data, is that this shorter signaling burst pushes osteoblast-driven bone formation while triggering less of the osteoclast-driven resorption that PTH-type drugs also switch on. In practice that can mean a wider anabolic window and somewhat less hypercalcemia than teriparatide, though it is the same overall receptor and pathway. It is still given as a once-daily subcutaneous injection, relying on the same pulsatile dosing logic that makes anabolic PTH therapy work.
What does the research show?
The core human evidence is the ACTIVE phase 3 trial, which randomized more than 2,400 postmenopausal women to abaloparatide, placebo, or open-label teriparatide for 18 months. Abaloparatide cut new vertebral fractures by about 86 percent and nonvertebral fractures by about 43 percent versus placebo, and reduced major osteoporotic fractures more than teriparatide did in that comparison. A cardiovascular safety analysis from ACTIVE was reassuring, though transient increases in heart rate are a known on-label effect of the class. The ATOM trial later supported the 2022 approval in men by showing bone-density gains comparable to those seen in women. Because abaloparatide is PTHR1-based like teriparatide, it originally carried the same rat-osteosarcoma-derived boxed warning and lifetime-use caution, and label thinking on that class evolved alongside the teriparatide updates. This is solid RCT-backed evidence, not preliminary research.
What doses have been studied?
Typical Dosingⓘ
Community experience
80 mcg daily
80 mcg daily
Once daily
A PTHrP analog for osteoporosis, similar to teriparatide with a different binding profile.
Research Dosingⓘ
Scientific studies
FDA-approved dosing
Doses from Studies
80 mcg subcutaneous daily
Duration
Maximum 2 years (same lifetime limit as teriparatide)
Administration
Subcutaneous injection daily
When and how is Abaloparatide taken?
Best Time to Take
Morning or as directed
Follow recommended protocol
Food Recommendation
With or without food
Why This Timing?
Timing may vary based on individual response and goals. Consistency is generally more important than specific timing.
What are the side effects of Abaloparatide?
Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.
- ●Hypercalciuria (11%)
- ●Dizziness (10%)
- ●Nausea (8%)
- ●Palpitations (5%)
- ●Injection site reactions
- ●Orthostatic hypotension
- ●Osteosarcoma risk in rats
References
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7500469/
- https://www.ncbi.nlm.nih.gov/books/NBK587447/
- https://www.healio.com/news/endocrinology/20221221/fda-approves-abaloparatide-for-men-with-osteoporosis-at-high-risk-for-fracture
- https://radiuspharm.com/radius-healths-tymlos-abaloparatide-receives-u-s-fda-approval-as-a-treatment-to-increase-bone-density-in-men-with-osteoporosis-at-high-risk-for-fracture/
Research This Peptide Further
Frequently Asked Questions
What does Abaloparatide do?
Abaloparatide (brand name Tymlos) is a synthetic 34-amino-acid analog of parathyroid hormone-related protein (PTHrP), and like teriparatide it is an anabolic osteoporosis drug that builds new bone. The FDA approved it in April 2017 for postmenopausal women at high fracture risk, and in December 2022 added men with osteoporosis at high fracture risk. It is the second drug in its class and was designed to lean harder on bone formation with less of the bone-breakdown and calcium-spike baggage.
How does Abaloparatide work?
Abaloparatide hits the same target as teriparatide, the PTH type 1 receptor (PTHR1), but it was engineered to favor a specific receptor conformation (the RG-bound state) that produces a more transient signal. The idea, supported by preclinical data, is that this shorter signaling burst pushes osteoblast-driven bone formation while triggering less of the osteoclast-driven resorption that PTH-type drugs also switch on. In practice that can mean a wider anabolic window and somewhat less hypercalcemia than teriparatide, though it is the same overall receptor and pathway. It is still given as a once-daily subcutaneous injection, relying on the same pulsatile dosing logic that makes anabolic PTH therapy work.
Is Abaloparatide FDA approved?
Yes, Abaloparatide is FDA approved. FDA Approved - Osteoporosis in postmenopausal women and men at high risk for fracture (male indication added Dec 2022)
Is Abaloparatide banned in sport?
Not on the WADA Prohibited List (2026).
What are the side effects of Abaloparatide?
Reported side effects include: Hypercalciuria (11%), Dizziness (10%), Nausea (8%), Palpitations (5%), Injection site reactions. Individual responses vary based on dosage, duration, and personal health factors.
What is the typical dose of Abaloparatide?
Community-reported common dose: 80 mcg daily (Once daily). Range: 80 mcg daily. Administration: Subcutaneous injection daily. Prescription drug. Dose set by prescriber per label. Not medical advice.
Related Peptides
Peptides commonly compared with Abaloparatide or used in similar applications.
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HormonalOctreotide
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HormonalLanreotide
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