Cognitive Peptides
Nootropic peptides researched for cognitive enhancement, memory, and neuroprotection.
About Cognitive Peptides
Cognitive peptides, also known as nootropic peptides, are being researched for their potential to enhance cognitive function, support memory, and provide neuroprotection. These include compounds like Semax and Selank (approved in Russia), Dihexa, and various other neuropeptides. They work through multiple mechanisms including modulating neurotransmitters, promoting neuroplasticity, enhancing BDNF expression, and protecting neurons from oxidative stress.
All Cognitive Peptides (9)
Selank
Clinical TrialsAlso: Selanc, TP-7
A synthetic peptide derived from tuftsin, an immunomodulatory peptide. Approved in Russia for anxiety and nootropic effects. Known for anxiolytic properties without sedation.
Semax
Clinical TrialsAlso: SEMAX, Heptapeptide SEMAX
A synthetic peptide derived from ACTH (4-10) fragment with added Pro-Gly-Pro sequence. Approved in Russia for stroke and cognitive enhancement. Known for nootropic and neuroprotective effects.
Cerebrolysin
Clinical TrialsAlso: FPE 1070
A mixture of low-molecular-weight neuropeptides derived from pig brain. Approved in many countries for stroke, traumatic brain injury, and dementia.
Dihexa
PreclinicalAlso: N-hexanoic-Tyr-Ile-(6) aminohexanoic amide
A potent cognitive-enhancing peptide derived from angiotensin IV. Reported to be 10 million times more potent than BDNF at promoting synaptogenesis.
P21
PreclinicalAlso: P021, Ac-DGGLAG-NH2
A synthetic peptide mimetic of CNTF (ciliary neurotrophic factor) designed for neurodegenerative disease. Promotes neurogenesis and reduces neuroinflammation.
GB-115
Clinical TrialsAlso: Ranquilon, N-phenylacetyl-L-prolylglycine ethyl ester
A dipeptide anxiolytic and nootropic that acts as a CCK-1 (cholecystokinin) receptor antagonist. Developed in Russia with completed Phase 3 trials for anxiety. Users report significant improvements in focus, attention, and ADHD-like symptoms.
ARA-290
Clinical TrialsAlso: Cibinetide, ARA 290
An 11-amino acid peptide derived from erythropoietin (EPO) that activates the innate repair receptor. Unlike EPO, it has no erythropoietic activity but provides cytoprotective, anti-inflammatory, and tissue-protective effects.
Normoftal
Clinical TrialsAlso: Eye Peptide Bioregulator, Retina Peptide
A synthesized Khavinson peptide bioregulator containing short peptides (2-4 amino acids) derived from retinal tissue. Developed to normalize retinal function and support eye health. Clinical studies in Russia report improved visual function in 95% of patients with various retinal pathologies.
PE-22-28
PreclinicalAlso: PE22-28, Spadin Analog
A synthetic heptapeptide (7 amino acids) derived from Spadin, a naturally occurring antidepressant peptide. PE-22-28 is a shorter, more stable analog that retains the antidepressant and anxiolytic properties of Spadin. Works by blocking TREK-1 potassium channels in the brain.
Frequently Asked Questions About Cognitive Peptides
What are cognitive peptides?
Cognitive peptides are short amino acid chains researched for their potential to enhance mental performance, support memory formation, reduce anxiety, and provide neuroprotective effects. Examples include Semax, Selank, and Dihexa.
How does Semax work?
Semax is a synthetic peptide derived from ACTH that has been shown to increase BDNF expression, modulate dopamine and serotonin systems, and enhance cognitive function. It's approved as a medication in Russia for stroke and cognitive disorders.
Are nootropic peptides safe?
Safety profiles vary by peptide. Semax and Selank have been used medically in Russia with documented safety data. However, most cognitive peptides lack FDA approval and long-term human safety studies. Consult healthcare providers before use.