peptibase

The peptibase journal

Peptide science, minus the hype.

Research guides, mechanism breakdowns, and protocol notes. Written for people who actually read the studies.

23 articles

Retatrutide Just Hit Bariatric-Surgery Numbers in Phase 3. The FDA Says Wait Until 2027.
Industry News
Featured

Retatrutide Just Hit Bariatric-Surgery Numbers in Phase 3. The FDA Says Wait Until 2027.

Lilly's TRIUMPH-1 just posted 28.3% average body weight loss at 80 weeks. That's bariatric surgery territory, from a single weekly injection. The NDA filing is Q4 2026. FDA approval is 2027 at the earliest. Here's what the data says, what it means for tirzepatide users, and the access conversation nobody wants to have.

May 23, 20268 min read
22 more articles
The FDA Just Caught Up To What The Research Community Already Knew
Industry News

The FDA Just Caught Up To What The Research Community Already Knew

HHS announced April 15 that 12 peptides are moving from Category 2 back to Category 1 for compounding. Here's what that actually means, why nothing has legally changed yet, and why the regulated pathway won't be the affordable pathway for most people.

Apr 177 min read
A Non-Peptide Just Entered the GLP-1 Race: What Foundayo Means for Peptide Users
Industry News

A Non-Peptide Just Entered the GLP-1 Race: What Foundayo Means for Peptide Users

The FDA just approved a weight loss pill that isn't a peptide. Peptide-based GLP-1s still win on efficacy. But the landscape just shifted. Here's what peptide users need to know.

Apr 510 min read
Chinese Peptide Factories: The Supply Chain Behind Every Vendor (And Why We Cut Out the Middleman)
Safety & Quality

Chinese Peptide Factories: The Supply Chain Behind Every Vendor (And Why We Cut Out the Middleman)

Almost every peptide sold online originates from Chinese synthesis labs. We decided to go direct to the source, so you get factory prices with full quality verification.

Apr 110 min read
TB-500: The Recovery Peptide Athletes Won't Shut Up About
Research Guides

TB-500: The Recovery Peptide Athletes Won't Shut Up About

TB-500 is one of the most popular healing peptides alongside BPC-157. Here is what the research actually shows about its effects, side effects, and why athletes keep talking about it.

Mar 2810 min read
FDA Peptide Reclassification 2026: Complete Guide to What Changed
Industry News

FDA Peptide Reclassification 2026: Complete Guide to What Changed

On February 27, 2026, 14 peptides were announced to return from Category 2 to Category 1. Here is everything you need to know about what changed, which peptides are affected, and what it means.

Mar 2011 min read
Peptide Sciences Shut Down: Where to Find Trusted Vendors in 2026
Industry News

Peptide Sciences Shut Down: Where to Find Trusted Vendors in 2026

Peptide Sciences closed without warning in March 2026. Here are the verified alternatives our community trusts, with real reviews and exclusive discount codes.

Mar 189 min read
Why Are Peptides Being Restricted? The Regulatory Landscape Explained
Industry News

Why Are Peptides Being Restricted? The Regulatory Landscape Explained

The FDA is going after research peptides — compounds with zero documented deaths — while drugs that kill hundreds of thousands of people a year stay on TV commercials. Here's what's really going on, what the numbers actually say, and why this whole situation is messier than anyone wants to admit. 🤔

Mar 1712 min read
Growth Hormone Peptides and Cancer Risk: What the Research Actually Shows
Peptide Science

Growth Hormone Peptides and Cancer Risk: What the Research Actually Shows

Everyone's heard the claim that GH-releasing peptides like Tesamorelin, CJC-1295, and Ipamorelin cause cancer. Sounds scary — but does the actual clinical evidence back it up? We went through the data so you don't have to.

Mar 1310 min read
Melanotan 2: Way More Than a Tanning Peptide
Peptide Science

Melanotan 2: Way More Than a Tanning Peptide

Most people write off Melanotan 2 as a tanning or libido thing. Honestly? That barely scratches the surface. It taps into melanocortin receptors across nearly every major organ system — and the research on what that means is kind of wild.

Mar 1012 min read
TB-500 and Heart Repair: What the Cardiac Fibrosis Research Actually Shows
Peptide Science

TB-500 and Heart Repair: What the Cardiac Fibrosis Research Actually Shows

TB-500 isn't just for tendon injuries — turns out, the research on heart repair is kind of wild. Published studies show it may actually reverse cardiac fibrosis, cut arrhythmias by 67%, and break the vicious heart-kidney disease cycle. Let's dig into what the science says.

Mar 712 min read
Cardarine (GW501516): What the Research Actually Says About the Cancer Myth
Research Guides

Cardarine (GW501516): What the Research Actually Says About the Cancer Myth

Cardarine isn't a peptide — it's a PPAR-delta agonist with a reputation that's... complicated. Let's dig into what the studies actually show about its metabolic effects, that infamous cancer scare, and why context matters way more than headlines.

Mar 310 min read
BPC-157 As a "Forever Peptide": The Case for Long-Term, Low-Dose Use
Expert Analysis

BPC-157 As a "Forever Peptide": The Case for Long-Term, Low-Dose Use

Most people pop BPC-157 for an injury and call it a day. But here's the thing — emerging research suggests that low-dose, daily BPC-157 might offer systemic benefits that quietly compound over months and years. Let's dig into what the science actually says.

Feb 2712 min read
Retatrutide: Why Researchers Think This Triple Agonist Goes Far Beyond Weight Loss
Peptide Science

Retatrutide: Why Researchers Think This Triple Agonist Goes Far Beyond Weight Loss

Retatrutide hits GLP-1, GIP, and glucagon receptors all at once. And honestly? The weight loss might be the least interesting thing it does.

Feb 2312 min read
Retatrutide: The Triple-Agonist That's Breaking Weight Loss Records
Trending

Retatrutide: The Triple-Agonist That's Breaking Weight Loss Records

28.7% body weight loss in Phase 3 trials. Here's everything you need to know about the most powerful weight loss peptide in development.

Feb 188 min read
The Wolverine Stack: BPC-157 + TB-500 for Accelerated Healing
Research Guides

The Wolverine Stack: BPC-157 + TB-500 for Accelerated Healing

Why the combination of BPC-157 and TB-500 has become the go-to protocol for injury recovery. What the research says and how people actually use it.

Feb 1510 min read
BPC-157 and the FDA: What the 2026 Crackdown Means for You
Safety

BPC-157 and the FDA: What the 2026 Crackdown Means for You

The FDA is targeting research peptides. Here's what changed, why it matters, and what options remain for those interested in BPC-157.

Feb 119 min read
How to Reconstitute Peptides Without Ruining Them (Step-by-Step)
Education

How to Reconstitute Peptides Without Ruining Them (Step-by-Step)

From bacteriostatic water calculations to proper injection technique, everything you need to know about preparing research peptides safely.

Feb 710 min read
Are Peptides Safe? Here's What We Actually Know
Safety

Are Peptides Safe? Here's What We Actually Know

Let's cut through the noise. Some peptides have 40+ years of safety data. Others? We're still figuring it out. Here's the honest breakdown.

Feb 48 min read
How Long Do Peptides Last? Shelf Life Facts Most Vendors Won't Tell You
Education

How Long Do Peptides Last? Shelf Life Facts Most Vendors Won't Tell You

Temperature, light, moisture - which factors actually affect peptide stability? A practical guide to storing your peptides correctly.

Feb 39 min read
5 Peptide Stacks That Actually Work in 2026 (With Dosing)
Research Guides

5 Peptide Stacks That Actually Work in 2026 (With Dosing)

Which peptides actually work well together? We break down the most effective research-backed stacks for healing, longevity, weight loss, and more.

Jan 3012 min read
Peptides vs SARMs in 2026: Safety, Legality & What Actually Works
Comparisons

Peptides vs SARMs in 2026: Safety, Legality & What Actually Works

Both are research compounds, both are popular in fitness circles, but they're fundamentally different. Here's what you need to know about each.

Jan 2612 min read
Peptides 101: Everything You Need to Know (Without the PhD)
Education

Peptides 101: Everything You Need to Know (Without the PhD)

New to peptides? Same confusing acronyms everywhere? Let's break it down. What they are, how they work, how to use them - explained like you're a smart friend, not a lab rat.

Jan 2318 min read

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BPC-157GLP-1SemaglutideTirzepatideGHK-CuTB-500Healing PeptidesWeight Loss