ACE-031
Also known as: ACVR2B-Fc, Myostatin Inhibitor
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ACE-031 from $99/kit
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Key Facts: ACE-031
- Category
- Hormonal
- FDA Status
- Not FDA Approved
- Clinical Status
- Development halted - Safety concerns
- Administration
- Subcutaneous injection
- Typical Dose
- Limited community data available
- Frequency
- See research protocols
- Duration
- Trials discontinued
Mechanism of Action
ACE-031 is a fusion protein combining the activin IIB receptor with antibody Fc domain. It acts as a decoy receptor, binding and neutralizing myostatin, GDF11, and activins to promote muscle growth.
Research Summary
Phase II trials in Duchenne MD showed significant muscle mass increase but were halted due to nosebleeds and gum bleeding. The broad ligand binding may cause unwanted vascular effects.
Dosing Information
Note: Animal study doses may not translate directly to humans.
Typical Dosingⓘ
Community experience
Limited community data available
See research dosing
See research protocols
Research Dosingⓘ
Scientific studies
From clinical trials before discontinuation
Doses from Studies
0.5-3 mg/kg every 2 weeks in trials
Duration
Trials discontinued
Administration
Subcutaneous injection
Timing & Administration
Best Time to Take
Morning, same day each week
Once weekly
Food Recommendation
With or without food
Why This Timing?
ACE-031 is a myostatin inhibitor with weekly dosing. Morning allows for monitoring.
Possible Side Effects
Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.
- ●Nosebleeds
- ●Gum bleeding
- ●Spider veins (telangiectasias)
- ●Injection site reactions
- ●FSH level decrease
- ●Clinical trials discontinued due to safety
References
- https://pubmed.ncbi.nlm.nih.gov/27462804/
- https://pubmed.ncbi.nlm.nih.gov/23169607/
- https://pubmed.ncbi.nlm.nih.gov/24981864/
Research This Peptide Further
Buy in shop
ACE-031 from $99/kit
2 verified vendors, ≥99% purity, COAs included.
Frequently Asked Questions
What does ACE-031 do?
A soluble activin receptor that traps myostatin. Developed for muscular dystrophy but trials halted due to safety concerns.
How does ACE-031 work?
ACE-031 is a fusion protein combining the activin IIB receptor with antibody Fc domain. It acts as a decoy receptor, binding and neutralizing myostatin, GDF11, and activins to promote muscle growth.
Is ACE-031 FDA approved?
No, ACE-031 is not currently FDA approved. Current status: Development halted - Safety concerns
What are the side effects of ACE-031?
Reported side effects include: Nosebleeds, Gum bleeding, Spider veins (telangiectasias), Injection site reactions, FSH level decrease. Individual responses vary based on dosage, duration, and personal health factors.
What is the typical dose of ACE-031?
Community-reported common dose: Limited community data available (See research protocols). Range: See research dosing. Administration: Subcutaneous injection. Community-reported doses. Not medical advice. Consult healthcare provider.
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