Kisspeptin
Also known as: Kisspeptin-10, Kisspeptin-54, Metastin
Key Facts: Kisspeptin
- Category
- Hormonal
- FDA Status
- Not FDA Approved
- Clinical Status
- Investigational - Clinical trials ongoing
- Administration
- IV (research), subcutaneous (investigational)
- Typical Dose
- 100-200 mcg subcutaneously once daily
- Frequency
- Once daily or every other day
- Evidence Level
- Human Trials
- Duration
- Variable by protocol
What to Expect
A neuropeptide that plays a critical role in initiating puberty and regulating the reproductive hormone axis. Being studied for fertility and hormonal disorders.
Mechanism of Action
Kisspeptin binds to the KISS1R receptor in the hypothalamus, triggering GnRH release. This initiates the hormonal cascade leading to LH and FSH release, which regulate testosterone and estrogen production. It's the master regulator of reproductive hormones.
Research Summary
Research shows kisspeptin administration can restore reproductive function in hypothalamic amenorrhea. Studies demonstrate effects on testosterone production and potential for fertility treatment. Being investigated for hypogonadism and reproductive disorders.
Dosing Information
Typical Dosingⓘ
Community experience
100-200 mcg subcutaneously once daily
50-500 mcg per day
Once daily or every other day
Subcutaneous injection to abdomen or thigh. Morning dosing preferred for hormone rhythm alignment. Often used with TRT to preserve fertility (works at hypothalamus level to stimulate GnRH). Typical cycles are 4-6 weeks. Start at 50-100 mcg and titrate based on response.
Research Dosingⓘ
Scientific studies
Doses from research studies
Doses from Studies
Kisspeptin-10: 1-10 nmol/kg IV
Subcutaneous protocols vary
Duration
Variable by protocol
Administration
IV (research), subcutaneous (investigational)
Timing & Administration
Best Time to Take
Morning or as directed
As clinically directed
Food Recommendation
With or without food
Why This Timing?
Kisspeptin affects reproductive hormones. Timing may vary based on specific therapeutic goals.
Possible Side Effects
Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.
- ●Generally very well-tolerated
- ●No serious adverse events in trials
- ●Temporary flushing
- ●Mild headache
- ●Nausea
- ●Long-term hormonal effects unknown
References
Related Peptides
Peptides commonly compared with Kisspeptin or used in similar applications.
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HormonalGonadorelin
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HormonalLeuprolide
FDAA GnRH agonist that suppresses testosterone and estrogen production. FDA approved for prostate cancer, endometriosis, uterine fibroids, and precocious puberty.
HormonalDesmopressin
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HormonalOctreotide
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Educational Information Only
This information is provided for educational purposes only and is not intended as medical advice. Always consult with qualified healthcare providers before making any decisions about peptides or other substances. The protocols listed reflect doses observed in research studies, not recommendations.