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Hormonal

Macimorelin

Also known as: Macrilen, AEZS-130

FDA Approved
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Key Facts: Macimorelin

Category
Hormonal
FDA Status
FDA Approved
Clinical Status
FDA Approved - Diagnostic for AGHD
Administration
Oral solution, fasting
Typical Dose
Limited community data available
Frequency
See research protocols
Evidence Level
FDA Approved
Duration
Single diagnostic test
Also Known As
Macrilen, AEZS-130

What to Expect

An oral ghrelin mimetic used to diagnose adult growth hormone deficiency. The first FDA-approved oral GH stimulation test.

Mechanism of Action

Macimorelin activates ghrelin receptors (GHSR-1a), stimulating GH release from the pituitary. As an oral agent, it's more convenient than injectable stimulation tests like ITT or glucagon.

Research Summary

Studies showed 92% concordance with insulin tolerance test. Single oral dose followed by blood draws provides reliable AGHD diagnosis. Much safer and simpler than previous gold standard tests.

Clinical Status:FDA Approved - Diagnostic for AGHD
Trial Progress:FDA Approved
Pre
I
II
III
IV
FDA

Dosing Information

FDA Approved·Human clinical trials completed, FDA approved

Typical Dosingⓘ

Community experience

Common Dose

Limited community data available

Range

See research dosing

Frequency

See research protocols

Research Dosingⓘ

Scientific studies

FDA-approved diagnostic protocol

Doses from Studies

Duration

Single diagnostic test

Administration

Oral solution, fasting

Timing & Administration

Best Time to Take

Morning or as directed

Follow recommended protocol

Food Recommendation

With or without food

Why This Timing?

Timing may vary based on individual response and goals. Consistency is generally more important than specific timing.

Possible Side Effects

Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.

  • ●Taste changes (dysgeusia)
  • ●Dizziness
  • ●Headache
  • ●Nausea
  • ●QT prolongation
  • ●FDA approved (Macrilen) for diagnostic use

References

Related Peptides

Peptides commonly compared with Macimorelin or used in similar applications.

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Pegvisomant

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A GH receptor antagonist that blocks growth hormone action. Used for acromegaly when surgery and somatostatin analogs fail to normalize IGF-1.

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Oxytocin

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A naturally occurring peptide hormone crucial for social bonding, childbirth, and lactation. Being studied for autism, anxiety, and social disorders.

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Leuprolide

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A GnRH agonist that suppresses testosterone and estrogen production. FDA approved for prostate cancer, endometriosis, uterine fibroids, and precocious puberty.

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Desmopressin

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A synthetic analog of vasopressin (ADH) used for diabetes insipidus, bedwetting, and bleeding disorders. Does not cause vasoconstriction like natural vasopressin.

Hormonal
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Educational Information Only

This information is provided for educational purposes only and is not intended as medical advice. Always consult with qualified healthcare providers before making any decisions about peptides or other substances. The protocols listed reflect doses observed in research studies, not recommendations.

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