Semax
Also known as: SEMAX, Heptapeptide SEMAX
Key Facts: Semax
- Category
- Cognitive
- FDA Status
- Not FDA Approved
- Clinical Status
- Approved in Russia - Not FDA approved
- Administration
- Intranasal spray (most common)
- Typical Dose
- 200-600 mcg intranasal daily
- Frequency
- 1-3x daily, intranasal
- Evidence Level
- Human Trials
- Duration
- 10-30 days typical
What to Expect
A synthetic peptide derived from ACTH (4-10) fragment with added Pro-Gly-Pro sequence. Approved in Russia for stroke and cognitive enhancement. Known for nootropic and neuroprotective effects.
Mechanism of Action
Semax increases BDNF and NGF expression, modulates dopamine and serotonin systems, and has anti-inflammatory effects in the brain. It enhances neuroplasticity and protects neurons from oxidative stress and excitotoxicity.
Research Summary
Russian research shows cognitive enhancement, improved memory and attention, and benefits for stroke recovery. Studies demonstrate increased BDNF levels and neuroprotective effects. Used clinically in Russia for stroke, TBI, and cognitive disorders.
Dosing Information
Typical Dosingⓘ
Community experience
200-600 mcg intranasal daily
100-900 mcg daily
1-3x daily, intranasal
Nootropic peptide, used intranasally. Effects are subtle and cognitive. Can be combined with Selank for anxiety/focus.
Research Dosingⓘ
Scientific studies
Doses from clinical practice
Doses from Studies
300-600 mcg intranasal
Up to 3x daily
Duration
10-30 days typical
Administration
Intranasal spray (most common)
Timing & Administration
Best Time to Take
Morning or early afternoon
2-3 times daily, last dose before 3 PM
Food Recommendation
With or without food
Why This Timing?
Semax has stimulating cognitive effects. Morning use maximizes focus benefits during work hours without affecting sleep.
Possible Side Effects
Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.
- ●Nasal irritation (common)
- ●Headache
- ●Insomnia
- ●Increased anxiety (paradoxical in some)
- ●Nausea
- ●No serious adverse events in trials
- ●Caution with SSRIs and MAOIs
References
Related Peptides
Peptides commonly compared with Semax or used in similar applications.
Selank
Clinical TrialsA synthetic peptide derived from tuftsin, an immunomodulatory peptide. Approved in Russia for anxiety and nootropic effects. Known for anxiolytic properties without sedation.
CognitiveCerebrolysin
Clinical TrialsA mixture of low-molecular-weight neuropeptides derived from pig brain. Approved in many countries for stroke, traumatic brain injury, and dementia.
CognitiveDihexa
PreclinicalA potent cognitive-enhancing peptide derived from angiotensin IV. Reported to be 10 million times more potent than BDNF at promoting synaptogenesis.
CognitiveGB-115
Clinical TrialsA dipeptide anxiolytic and nootropic that acts as a CCK-1 (cholecystokinin) receptor antagonist. Developed in Russia and currently in clinical trials for anxiety and cognitive enhancement. Users report significant improvements in focus, attention, and ADHD-like symptoms.
CognitiveP21
PreclinicalA synthetic peptide mimetic of CNTF (ciliary neurotrophic factor) designed for neurodegenerative disease. Promotes neurogenesis and reduces neuroinflammation.
CognitiveARA-290
Clinical TrialsAn 11-amino acid peptide derived from erythropoietin (EPO) that activates the innate repair receptor. Unlike EPO, it has no erythropoietic activity but provides cytoprotective, anti-inflammatory, and tissue-protective effects.
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Educational Information Only
This information is provided for educational purposes only and is not intended as medical advice. Always consult with qualified healthcare providers before making any decisions about peptides or other substances. The protocols listed reflect doses observed in research studies, not recommendations.