Dihexa
Also known as: N-hexanoic-Tyr-Ile-(6) aminohexanoic amide
Popular For
Memory enhancement, cognitive performance, neuroplasticity
Key Facts: Dihexa
- Category
- Cognitive
- FDA Status
- Not FDA Approved
- Clinical Status
- Preclinical - Research compound
- Administration
- Oral, sublingual, or intranasal
- Typical Dose
- 5-20 mg oral or sublingual daily
- Frequency
- Once daily, effects can last up to 10 days
- Evidence Level
- Animal Studies
- Duration
- Cycles of 2-4 weeks
Mechanism of Action
Dihexa activates hepatocyte growth factor (HGF) signaling through the c-Met receptor. This promotes dendritic spine formation, enhances synaptic connections, and supports neuronal survival. Crosses blood-brain barrier orally.
Research Summary
Animal studies show remarkable cognitive enhancement and reversal of scopolamine-induced memory deficits. Research demonstrates increased dendritic spine density. Limited human data but significant interest in nootropic community.
Dosing Information
Note: Animal study doses may not translate directly to humans.
Typical Dosingⓘ
Community experience
5-20 mg oral or sublingual daily
5-40 mg daily (some report up to 80 mg)
Once daily, effects can last up to 10 days
Orally bioavailable (38% absorption). Crosses blood-brain barrier. Cycle 90 days on, 30 days off recommended. CAUTION: Activates c-Met pathway which may promote cancer cell growth - avoid if history of cancer. NO human clinical trials have been conducted; all data is from animal studies. Start low (5 mg) to assess tolerance.
Research Dosingⓘ
Scientific studies
Doses from research/anecdotal use
Doses from Studies
10-20 mg oral or sublingual
5-10 mg intranasal
Duration
Cycles of 2-4 weeks
Administration
Oral, sublingual, or intranasal
Timing & Administration
Best Time to Take
Morning
Once daily in the morning
Food Recommendation
With or without food
Why This Timing?
Dihexa supports cognitive function and memory. Morning dosing aligns with peak cognitive demands.
Possible Side Effects
Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.
- ●Nervousness
- ●Headache
- ●Anxiety
- ●Insomnia
- ●Nausea
- ●Potential bleeding problems
- ●Concerns about tumor development
- ●NO human clinical trials
References
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