Selank
Also known as: Selanc, TP-7
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Selank from $55/kit
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Key Facts: Selank
- Category
- Cognitive
- FDA Status
- Not FDA Approved
- Clinical Status
- Approved in Russia - Not FDA approved. Removed from Category 2 Sept 2024; expected reclassification to Category 1 (April 15, 2026 HHS announcement; remains Category 2 under current law until formal FDA rule; PCAC review July 23-24, 2026)
- Administration
- Intranasal spray (most common), subcutaneous injection
- Typical Dose
- 250-500 mcg intranasal 2-3x daily
- Frequency
- 2-3x daily, intranasal
- Duration
- 14-21 days typical
Mechanism of Action
Selank modulates the expression of BDNF (brain-derived neurotrophic factor), influences serotonin and dopamine metabolism, and has effects on the GABAergic system. It also has immunomodulatory properties inherited from its tuftsin backbone.
Research Summary
Russian clinical trials demonstrate anxiolytic effects comparable to benzodiazepines without sedation or addiction potential. Studies show improved cognitive function under stress, enhanced memory, and stabilization of mood. Note: Selank was removed from FDA Category 2 in September 2024 when nominators withdrew the substance - now scheduled for PCAC review.
Dosing Information
Typical Dosingⓘ
Community experience
250-500 mcg intranasal 2-3x daily
200-750 mcg per dose
2-3x daily, intranasal
Anxiolytic nootropic. Used intranasally. Effects build over days/weeks. Often stacked with Semax.
Research Dosingⓘ
Scientific studies
Doses from clinical practice
Doses from Studies
250-500 mcg intranasal
Up to 3x daily
Duration
14-21 days typical
Administration
Intranasal spray (most common), subcutaneous injection
Timing & Administration
Best Time to Take
Morning or as needed for anxiety
2-3 times daily as needed
Food Recommendation
With or without food
Why This Timing?
Selank has anxiolytic effects without sedation. Morning use helps manage daytime stress and anxiety.
Possible Side Effects
Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.
- ●Generally well-tolerated
- ●Nasal irritation (spray)
- ●Headache
- ●Nausea
- ●Fatigue
- ●Non-sedative and non-addictive
- ●May enhance effects of benzodiazepines
- ●Approved in Russia for anxiety
References
- https://pubmed.ncbi.nlm.nih.gov/18454096/
- https://pubmed.ncbi.nlm.nih.gov/28280289/
- https://pubmed.ncbi.nlm.nih.gov/30255741/
Research This Peptide Further
Buy in shop
Selank from $55/kit
3 verified vendors, ≥99% purity, COAs included.
Frequently Asked Questions
What does Selank do?
A synthetic peptide derived from tuftsin, an immunomodulatory peptide. Approved in Russia for anxiety and nootropic effects. Known for anxiolytic properties without sedation.
How does Selank work?
Selank modulates the expression of BDNF (brain-derived neurotrophic factor), influences serotonin and dopamine metabolism, and has effects on the GABAergic system. It also has immunomodulatory properties inherited from its tuftsin backbone.
Is Selank FDA approved?
No, Selank is not currently FDA approved. Current status: Approved in Russia - Not FDA approved. Removed from Category 2 Sept 2024; expected reclassification to Category 1 (April 15, 2026 HHS announcement; remains Category 2 under current law until formal FDA rule; PCAC review July 23-24, 2026)
What are the side effects of Selank?
Reported side effects include: Generally well-tolerated, Nasal irritation (spray), Headache, Nausea, Fatigue. Individual responses vary based on dosage, duration, and personal health factors.
What is the typical dose of Selank?
Community-reported common dose: 250-500 mcg intranasal 2-3x daily (2-3x daily, intranasal). Range: 200-750 mcg per dose. Administration: Intranasal spray (most common), subcutaneous injection. Community-reported doses. Not medical advice. Consult healthcare provider.
Related Peptides
Peptides commonly compared with Selank or used in similar applications.
Semax
Clinical TrialsA synthetic peptide derived from ACTH (4-10) fragment with added Pro-Gly-Pro sequence. Approved in Russia for stroke and cognitive enhancement. Known for nootropic and neuroprotective effects.
CognitiveCerebrolysin
Clinical TrialsA mixture of low-molecular-weight neuropeptides derived from pig brain. Approved in many countries for stroke, traumatic brain injury, and dementia.
CognitiveDihexa
PreclinicalA potent cognitive-enhancing peptide derived from angiotensin IV. Reported to be 10 million times more potent than BDNF at promoting synaptogenesis.
CognitiveGB-115
Clinical TrialsA dipeptide anxiolytic and nootropic that acts as a CCK-1 (cholecystokinin) receptor antagonist. Developed in Russia with completed Phase 3 trials for anxiety. Users report significant improvements in focus, attention, and ADHD-like symptoms.
CognitiveNormoftal
Clinical TrialsA synthesized Khavinson peptide bioregulator containing short peptides (2-4 amino acids) derived from retinal tissue. Developed to normalize retinal function and support eye health. Clinical studies in Russia report improved visual function in 95% of patients with various retinal pathologies.
CognitivePE-22-28
PreclinicalA synthetic heptapeptide (7 amino acids) derived from Spadin, a naturally occurring antidepressant peptide. PE-22-28 is a shorter, more stable analog that retains the antidepressant and anxiolytic properties of Spadin. Works by blocking TREK-1 potassium channels in the brain.
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