Selank
Also known as: Selanc, TP-7
Key Facts: Selank
- Category
- Cognitive
- FDA Status
- Not FDA Approved
- Clinical Status
- Approved in Russia - Not FDA approved
- Administration
- Intranasal spray (most common), subcutaneous injection
- Typical Dose
- 250-500 mcg intranasal 2-3x daily
- Frequency
- 2-3x daily, intranasal
- Evidence Level
- Human Trials
- Duration
- 14-21 days typical
What to Expect
A synthetic peptide derived from tuftsin, an immunomodulatory peptide. Approved in Russia for anxiety and nootropic effects. Known for anxiolytic properties without sedation.
Mechanism of Action
Selank modulates the expression of BDNF (brain-derived neurotrophic factor), influences serotonin and dopamine metabolism, and has effects on the GABAergic system. It also has immunomodulatory properties inherited from its tuftsin backbone.
Research Summary
Russian clinical trials demonstrate anxiolytic effects comparable to benzodiazepines without sedation or addiction potential. Studies show improved cognitive function under stress, enhanced memory, and stabilization of mood.
Dosing Information
Typical Dosingⓘ
Community experience
250-500 mcg intranasal 2-3x daily
200-750 mcg per dose
2-3x daily, intranasal
Anxiolytic nootropic. Used intranasally. Effects build over days/weeks. Often stacked with Semax.
Research Dosingⓘ
Scientific studies
Doses from clinical practice
Doses from Studies
250-500 mcg intranasal
Up to 3x daily
Duration
14-21 days typical
Administration
Intranasal spray (most common), subcutaneous injection
Timing & Administration
Best Time to Take
Morning or as needed for anxiety
2-3 times daily as needed
Food Recommendation
With or without food
Why This Timing?
Selank has anxiolytic effects without sedation. Morning use helps manage daytime stress and anxiety.
Possible Side Effects
Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.
- ●Generally well-tolerated
- ●Nasal irritation (spray)
- ●Headache
- ●Nausea
- ●Fatigue
- ●Non-sedative and non-addictive
- ●May enhance effects of benzodiazepines
- ●Approved in Russia for anxiety
References
Related Peptides
Peptides commonly compared with Selank or used in similar applications.
Semax
Clinical TrialsA synthetic peptide derived from ACTH (4-10) fragment with added Pro-Gly-Pro sequence. Approved in Russia for stroke and cognitive enhancement. Known for nootropic and neuroprotective effects.
CognitiveCerebrolysin
Clinical TrialsA mixture of low-molecular-weight neuropeptides derived from pig brain. Approved in many countries for stroke, traumatic brain injury, and dementia.
CognitiveDihexa
PreclinicalA potent cognitive-enhancing peptide derived from angiotensin IV. Reported to be 10 million times more potent than BDNF at promoting synaptogenesis.
CognitiveGB-115
Clinical TrialsA dipeptide anxiolytic and nootropic that acts as a CCK-1 (cholecystokinin) receptor antagonist. Developed in Russia and currently in clinical trials for anxiety and cognitive enhancement. Users report significant improvements in focus, attention, and ADHD-like symptoms.
CognitiveP21
PreclinicalA synthetic peptide mimetic of CNTF (ciliary neurotrophic factor) designed for neurodegenerative disease. Promotes neurogenesis and reduces neuroinflammation.
CognitiveARA-290
Clinical TrialsAn 11-amino acid peptide derived from erythropoietin (EPO) that activates the innate repair receptor. Unlike EPO, it has no erythropoietic activity but provides cytoprotective, anti-inflammatory, and tissue-protective effects.
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Educational Information Only
This information is provided for educational purposes only and is not intended as medical advice. Always consult with qualified healthcare providers before making any decisions about peptides or other substances. The protocols listed reflect doses observed in research studies, not recommendations.