Best Peptides for Anti-Aging & Longevity
Longevity-focused peptides researched for cellular health, telomere support, and healthy aging.
Understanding Anti-Aging Peptides
Anti-aging peptides represent a frontier of longevity research. Epithalon, a synthetic tetrapeptide, has been shown to activate telomerase - the enzyme that maintains telomere length. Bioregulator peptides developed by Vladimir Khavinson target specific organs to support optimal gene expression. GHK-Cu has been shown to reset gene expression patterns toward a healthier state. While the science is promising, most anti-aging peptides lack extensive long-term human clinical trials.
Key Considerations
- Anti-aging effects are difficult to measure and validate in short-term studies
- Epithalon research shows telomerase activation, but human longevity data is limited
- Bioregulator peptides have primarily Russian research backing
- GH secretagogues may support anti-aging through improved body composition and recovery
- Lifestyle factors (diet, exercise, sleep) remain the foundation of healthy aging
Research Peptides (15)
These peptides are being researched but are not FDA approved. They should only be considered for research purposes or under medical supervision.
NAD+ Precursors
Clinical TrialsWhile not peptides, NAD+ precursors are frequently discussed alongside peptides in longevity circles. They boost cellular NAD+ levels, supporting energy metabolism and sirtuin activity.
Epithalon
Clinical TrialsA tetrapeptide studied for its effects on telomerase activation and potential anti-aging properties. Based on research by Professor Vladimir Khavinson.
Thymalin
Clinical TrialsA thymic peptide complex used in Russia for immune enhancement and anti-aging. Part of Professor Khavinson's bioregulator peptide research.
Crystagen
PreclinicalA tripeptide bioregulator supporting immune system function. Demonstrates age-associated immunoprotective properties in spleen tissue. Part of the Khavinson synthesized peptide series.
Ventfort
PreclinicalA peptide bioregulator targeting vascular tissue and blood vessels. Derived from blood vessel extracts, it supports healthy vascular function and vessel wall integrity. Part of the Khavinson bioregulator family.
DSIP
Clinical TrialsA neuropeptide that promotes deep delta wave sleep. First isolated from rabbit brains in 1977. Used for sleep optimization and stress reduction.
Humanin
PreclinicalA mitochondria-derived peptide discovered for its neuroprotective effects against Alzheimer's-related toxicity. Being studied for aging and metabolic benefits.
SS-31
Clinical TrialsA mitochondria-targeted peptide that improves cellular energy production. Being developed for heart failure and mitochondrial diseases.
Glutathione
Clinical TrialsThe body's master antioxidant - a tripeptide composed of glutamate, cysteine, and glycine. Found in every cell at concentrations similar to glucose (5mM). Essential for detoxification, immune function, and cellular protection against oxidative stress.
Pinealon
PreclinicalA synthetic tripeptide bioregulator targeting brain tissue. Part of Khavinson's peptide research, designed to support cognitive function and neuroprotection.
Vilon
PreclinicalA synthetic dipeptide bioregulator targeting thymic function. Part of Khavinson's peptide bioregulator research for immune and anti-aging effects.
Cartalax
PreclinicalA synthetic tripeptide bioregulator targeting cartilage tissue. Developed for joint health and cartilage regeneration.
Livagen
PreclinicalA tetrapeptide bioregulator (Lys-Glu-Asp-Ala) developed by Khavinson that modulates chromatin structure and gene expression. Research shows it can decondense heterochromatin and activate ribosomal genes, potentially restoring more youthful gene expression patterns in aging cells.
Ovagen
PreclinicalA tripeptide bioregulator (Glu-Asp-Leu) targeting liver and gastrointestinal tissue. Derived from liver tissue extracts, Ovagen modulates gene expression related to detoxification, antioxidant defense, and hepatocellular repair.
Cortagen
PreclinicalA tetrapeptide bioregulator (Ala-Glu-Asp-Pro) derived from cerebral cortex extracts. Studied for neuroprotection, neural differentiation, and cognitive support. Regulates neurotrophic signaling and synaptic stability.
Frequently Asked Questions
What is the best anti-aging peptide?
Epithalon is the most studied longevity peptide, with research showing telomerase activation and potential life extension in animal models. GHK-Cu has evidence for resetting gene expression toward healthier patterns. Bioregulator peptides like Thymalin and Vilon target specific organs for age-related support.
How does Epithalon work?
Epithalon activates telomerase, the enzyme responsible for maintaining telomere length at chromosome ends. Telomere shortening is associated with cellular aging. By activating telomerase, Epithalon may help maintain telomere length and cellular replication capacity.
Are anti-aging peptides proven to work?
Evidence varies significantly. Epithalon has animal studies showing increased lifespan and telomerase activation. GHK-Cu has research on gene expression and wound healing. However, rigorous long-term human studies proving anti-aging benefits are lacking for most peptides.
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Educational Information Only
This guide to anti-aging peptides is for educational purposes only and does not constitute medical advice. Many peptides discussed are not FDA approved for human use. Always consult with qualified healthcare providers before making decisions about peptides or other substances.