DSIP
Also known as: Delta Sleep Inducing Peptide, Delta Sleep-Inducing Peptide
Key Facts: DSIP
- Category
- Anti-Aging
- FDA Status
- Not FDA Approved
- Clinical Status
- Investigational - Mixed research results
- Administration
- Subcutaneous, intramuscular, or intranasal
- Typical Dose
- 100-250 mcg before bed
- Frequency
- Once daily, 30 min before sleep
- Evidence Level
- Human Trials
- Duration
- 2-4 weeks typical
What to Expect
A neuropeptide that promotes deep delta wave sleep. First isolated from rabbit brains in 1977. Used for sleep optimization and stress reduction.
Mechanism of Action
DSIP acts on various neurotransmitter systems including serotonin, dopamine, and GABA. It modulates cortisol secretion, has stress-protective effects, and promotes delta wave (deep sleep) patterns without suppressing REM sleep.
Research Summary
Studies show improved sleep architecture, particularly increased delta wave sleep. Research demonstrates cortisol normalization effects and potential benefits for chronic pain and withdrawal symptoms. Results are mixed with some studies showing significant effects and others not.
Dosing Information
Typical Dosingⓘ
Community experience
100-250 mcg before bed
50-300 mcg per dose
Once daily, 30 min before sleep
Delta sleep-inducing peptide. Used for sleep quality. Effects can be subtle. Some cycle it to prevent tolerance.
Research Dosingⓘ
Scientific studies
Doses from research protocols
Doses from Studies
100-300 mcg before bed
Some protocols use higher doses
Duration
2-4 weeks typical
Administration
Subcutaneous, intramuscular, or intranasal
Timing & Administration
Best Time to Take
30-60 minutes before bed
Once daily before bed
Food Recommendation
With or without food
Why This Timing?
DSIP (Delta Sleep Inducing Peptide) promotes deep sleep. Pre-bedtime dosing is essential for its sleep-enhancing effects.
Possible Side Effects
Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.
- ●Fatigue upon waking (dose-dependent)
- ●Injection site reactions
- ●Headache (rare)
- ●Nausea
- ●May trigger histamine release - use caution with MCAS or histamine sensitivity
- ●Risk of immunogenicity
- ●Limited clinical data
References
Related Peptides
Peptides commonly compared with DSIP or used in similar applications.
Glutathione
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Anti-AgingHumanin
PreclinicalA mitochondria-derived peptide discovered for its neuroprotective effects against Alzheimer's-related toxicity. Being studied for aging and metabolic benefits.
Anti-AgingNAD+ Precursors
Clinical TrialsWhile not peptides, NAD+ precursors are frequently discussed alongside peptides in longevity circles. They boost cellular NAD+ levels, supporting energy metabolism and sirtuin activity.
Anti-AgingSS-31
Clinical TrialsA mitochondria-targeted peptide that improves cellular energy production. Being developed for heart failure and mitochondrial diseases.
Anti-AgingBPC-157
PreclinicalA synthetic peptide derived from a protein found in human gastric juice. Known for its remarkable tissue healing properties across multiple body systems.
HealingTB-500
Clinical TrialsA synthetic 17-amino acid fragment of Thymosin Beta-4 (TB-4). NOT the same as TB-4 - TB-500 has a longer half-life (~2-4 days vs ~2 hours) and is the active region responsible for tissue repair and cell migration. Note: Many vendors mislabel TB-4 as 'TB-500' in premixed products.
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Educational Information Only
This information is provided for educational purposes only and is not intended as medical advice. Always consult with qualified healthcare providers before making any decisions about peptides or other substances. The protocols listed reflect doses observed in research studies, not recommendations.