Best Peptides for Muscle Growth
Growth hormone secretagogues and related peptides researched for muscle development, strength, and body composition.
Understanding Muscle Growth Peptides
Muscle growth peptides primarily work through enhancing growth hormone (GH) release or IGF-1 signaling. Growth hormone secretagogues (GHS) like Ipamorelin, CJC-1295, and GHRP-2/6 stimulate the body's natural GH production. MK-677 (technically not a peptide) is an oral GH secretagogue. These compounds may support muscle protein synthesis, recovery, and body composition when combined with proper training and nutrition. Growth hormone itself remains a controlled substance requiring prescription.
Key Considerations
- GH peptides work best with consistent training and adequate protein intake
- Combining GHRH analogs (CJC-1295) with GHRPs (Ipamorelin) may enhance effects
- Timing matters - many are taken before bed to amplify natural GH pulses
- Effects are gradual and subtle compared to exogenous HGH
- Most GH secretagogues are not FDA approved for muscle-building
FDA Approved Options (2)
Tesamorelin
Also: Egrifta, TH9507
An FDA-approved GHRH analog used to reduce excess abdominal fat in HIV-infected patients with lipodystrophy. One of the few peptides with FDA approval.
Lanreotide
Also: Somatuline, Somatuline Depot
A long-acting somatostatin analog similar to octreotide. FDA approved for acromegaly and gastroenteropancreatic neuroendocrine tumors.
Research Peptides (13)
These peptides are being researched but are not FDA approved. They should only be considered for research purposes or under medical supervision.
Ipamorelin
Clinical TrialsA selective growth hormone secretagogue that stimulates GH release without significantly affecting cortisol or prolactin. Considered one of the safest GHRPs.
Sermorelin
PreclinicalA truncated analog of natural GHRH containing the first 29 amino acids. Previously FDA-approved for pediatric GH deficiency, now used off-label for adult hormone optimization.
MK-677
Clinical TrialsAn orally active growth hormone secretagogue that mimics ghrelin. Not a peptide technically, but frequently discussed alongside GH peptides due to similar effects.
CJC-1295 DAC
Clinical TrialsA long-acting GHRH analog with Drug Affinity Complex for extended half-life. Provides sustained GH elevation for days with single injection.
CJC-1295
Clinical TrialsA synthetic analog of growth hormone-releasing hormone (GHRH) that stimulates GH release from the pituitary. Often combined with a GHRP like Ipamorelin for synergistic effects.
GHRP-6
Clinical TrialsOne of the first synthetic GH secretagogues developed. Strongly stimulates GH release and significantly increases appetite through ghrelin receptor activation.
GHRP-2
Clinical TrialsA synthetic hexapeptide that potently stimulates GH release. More potent than GHRP-6 with less appetite stimulation, but still elevates cortisol and prolactin.
Hexarelin
Clinical TrialsA synthetic hexapeptide GH secretagogue with the strongest GH-releasing effect among GHRPs. Also has notable cardioprotective properties independent of GH release.
BPC-157
PreclinicalA synthetic peptide derived from a protein found in human gastric juice. Known for its remarkable tissue healing properties across multiple body systems.
AOD-9604
Clinical TrialsA modified fragment of human growth hormone (amino acids 177-191) studied for fat metabolism effects without the broader hormonal effects of full GH.
Snap-8
ResearchA cosmetic peptide that reduces wrinkles by inhibiting muscle contraction. Often called 'Botox in a bottle' though mechanism differs from actual botulinum toxin.
Argireline
ResearchA popular cosmetic peptide that reduces facial wrinkles by inhibiting neurotransmitter release. One of the most widely used peptides in anti-aging skincare.
VIP
Clinical TrialsA naturally occurring peptide with immunomodulatory and anti-inflammatory effects. Being studied for ARDS, pulmonary hypertension, and autoimmune conditions.
Frequently Asked Questions
What peptides increase muscle growth?
GH secretagogues like Ipamorelin and CJC-1295 stimulate growth hormone release, which supports muscle protein synthesis and recovery. GHRP-2 and GHRP-6 also increase GH but may affect appetite and cortisol. These work best when combined with resistance training.
Is Ipamorelin good for building muscle?
Ipamorelin is a selective GH secretagogue that increases growth hormone without significantly affecting cortisol or prolactin. This cleaner profile makes it popular for body composition goals. It's often combined with CJC-1295 for enhanced and sustained GH release.
How do GH peptides compare to HGH?
GH peptides stimulate your body's own growth hormone production, maintaining more natural pulsatile patterns. Exogenous HGH provides direct GH replacement. Peptides generally have subtler effects but may be easier to dose and have fewer side effects than supraphysiological HGH doses.
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Compare Peptides Side-by-Side
Use our comparison tool to evaluate multiple peptides at once.
Educational Information Only
This guide to muscle growth peptides is for educational purposes only and does not constitute medical advice. Many peptides discussed are not FDA approved for human use. Always consult with qualified healthcare providers before making decisions about peptides or other substances.