A tetrapeptide bioregulator (Lys-Glu-Asp-Ala) developed by Khavinson that modulates chromatin structure and gene expression. Research shows it can decondense heterochromatin and activate ribosomal genes, potentially restoring more youthful gene expression patterns in aging cells.

Is Livagen FDA approved?

No, Livagen is not FDA approved. Current status: Preclinical research, approved in Russia as supplement

What are the side effects of Livagen?

Reported side effects of Livagen include: Generally well-tolerated, Limited safety data outside Russia, Not FDA approved.

What is the typical dosing for Livagen?

Doses from bioregulator supplement protocols. Common doses observed in research: 10-20 mg daily, Sublingual or oral administration. Duration: 10-30 day cycles. Administration: Oral capsules or sublingual.

Bioregulators

Livagen

Also known as: Lys-Glu-Asp-Ala, KEDA

Preclinical

Popular For

Gene expression, cellular aging, liver health

Key Facts: Livagen

Category: Bioregulators
FDA Status: Not FDA Approved
Clinical Status: Preclinical research, approved in Russia as supplement
Administration: Oral capsules or sublingual
Typical Dose: 10-20 mg daily
Frequency: Once or twice daily
Evidence Level: Preclinical
Duration: 10-30 day cycles

Also Known As

Lys-Glu-Asp-Ala, KEDA

Mechanism of Action

Livagen penetrates the cell nucleus and directly influences DNA transcription by decondensing chromatin structure. It activates ribosomal genes, modulates heterochromatin organization, and affects enkephalin-degrading enzyme activity. This allows previously silenced genes to become accessible for transcription, potentially restoring cellular function.

Research Summary

Studies in elderly subjects (75-88 years) showed Livagen activated ribosomal genes and induced decondensation of pericentromeric heterochromatin in lymphocytes. Research also demonstrated effects on the endogenous opioid system and immune cell function. Part of Khavinson's peptide bioregulator research spanning 40+ years.

Clinical Status:Preclinical research, approved in Russia as supplement

Trial Progress:Preclinical

Pre

III

FDA

Dosing Information

Preclinical·Animal and cell studies, limited human data

Note: Animal study doses may not translate directly to humans.

Typical DosingⓘDoses commonly used by people in practice, based on community reports and anecdotal experience.

Community experience

Common Dose

10-20 mg daily

Range

10-20 mg daily

Frequency

Once or twice daily

Khavinson bioregulator for liver. Oral or sublingual. Run in 10-30 day cycles.

Research DosingⓘDoses from published scientific studies and clinical trials. May include human or animal research.

Scientific studies

Doses from bioregulator supplement protocols

Doses from Studies

10-20 mg daily

Sublingual or oral administration

Duration

10-30 day cycles

Administration

Oral capsules or sublingual

Timing & Administration

Best Time to Take

Morning on empty stomach

Once or twice daily

Food Recommendation

Take on empty stomach

Why This Timing?

Peptide bioregulators typically taken fasted for optimal absorption

Possible Side Effects

Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.

●Generally well-tolerated
●Limited safety data outside Russia
●Not FDA approved

References

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