Livagen
Also known as: Lys-Glu-Asp-Ala, KEDA
Key Facts: Livagen
- Category
- Bioregulators
- FDA Status
- Not FDA Approved
- Clinical Status
- Preclinical research, approved in Russia as supplement
- Administration
- Oral capsules or sublingual
- Typical Dose
- 10-20 mg daily
- Frequency
- Once or twice daily
- Evidence Level
- Preclinical
- Duration
- 10-30 day cycles
What to Expect
A tetrapeptide bioregulator (Lys-Glu-Asp-Ala) developed by Khavinson that modulates chromatin structure and gene expression. Research shows it can decondense heterochromatin and activate ribosomal genes, potentially restoring more youthful gene expression patterns in aging cells.
Mechanism of Action
Livagen penetrates the cell nucleus and directly influences DNA transcription by decondensing chromatin structure. It activates ribosomal genes, modulates heterochromatin organization, and affects enkephalin-degrading enzyme activity. This allows previously silenced genes to become accessible for transcription, potentially restoring cellular function.
Research Summary
Studies in elderly subjects (75-88 years) showed Livagen activated ribosomal genes and induced decondensation of pericentromeric heterochromatin in lymphocytes. Research also demonstrated effects on the endogenous opioid system and immune cell function. Part of Khavinson's peptide bioregulator research spanning 40+ years.
Dosing Information
Typical Dosingⓘ
Community experience
10-20 mg daily
10-20 mg daily
Once or twice daily
Khavinson bioregulator for liver. Oral or sublingual. Run in 10-30 day cycles.
Research Dosingⓘ
Scientific studies
Doses from bioregulator supplement protocols
Doses from Studies
10-20 mg daily
Sublingual or oral administration
Duration
10-30 day cycles
Administration
Oral capsules or sublingual
Timing & Administration
Best Time to Take
Morning on empty stomach
Once or twice daily
Food Recommendation
Take on empty stomach
Why This Timing?
Peptide bioregulators typically taken fasted for optimal absorption
Possible Side Effects
Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.
- ●Generally well-tolerated
- ●Limited safety data outside Russia
- ●Not FDA approved
References
Related Peptides
Peptides commonly compared with Livagen or used in similar applications.
Ovagen
PreclinicalA tripeptide bioregulator (Glu-Asp-Leu) targeting liver and gastrointestinal tissue. Derived from liver tissue extracts, Ovagen modulates gene expression related to detoxification, antioxidant defense, and hepatocellular repair.
BioregulatorsCortagen
PreclinicalA tetrapeptide bioregulator (Ala-Glu-Asp-Pro) derived from cerebral cortex extracts. Studied for neuroprotection, neural differentiation, and cognitive support. Regulates neurotrophic signaling and synaptic stability.
BioregulatorsVesugen
PreclinicalA tripeptide bioregulator (Lys-Glu-Asp) targeting vascular tissue. Promotes restoration of blood vessel tissues and normalization of vascular function. Stimulates endothelial cell proliferation markers.
BioregulatorsChonluten
PreclinicalA tripeptide bioregulator targeting respiratory and lung tissue. Supports healthy lung function and stomach lining. Regulates inflammatory and proliferative processes in respiratory epithelium.
BioregulatorsCrystagen
PreclinicalA tripeptide bioregulator supporting immune system function. Demonstrates age-associated immunoprotective properties in spleen tissue. Part of the Khavinson synthesized peptide series.
BioregulatorsProstamax
PreclinicalA peptide bioregulator targeting prostate tissue. One of five highly efficient synthesized peptides developed by Khavinson with demonstrated effects on gene expression and tissue-specific regulation.
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Educational Information Only
This information is provided for educational purposes only and is not intended as medical advice. Always consult with qualified healthcare providers before making any decisions about peptides or other substances. The protocols listed reflect doses observed in research studies, not recommendations.