NAD+ Precursors
Also known as: NMN, NR, Nicotinamide Riboside, Nicotinamide Mononucleotide
Key Facts: NAD+ Precursors
- Category
- Anti-Aging
- FDA Status
- Not FDA Approved
- Clinical Status
- Available as supplements - Clinical trials ongoing
- Administration
- Oral (capsules, sublingual)
- Typical Dose
- Limited community data available
- Frequency
- See research protocols
- Evidence Level
- Human Trials
- Duration
- Ongoing supplementation
What to Expect
While not peptides, NAD+ precursors are frequently discussed alongside peptides in longevity circles. They boost cellular NAD+ levels, supporting energy metabolism and sirtuin activity.
Mechanism of Action
NMN and NR are converted to NAD+ in cells. NAD+ is essential for mitochondrial function, DNA repair, and sirtuin enzyme activity. Sirtuins regulate metabolism, stress response, and longevity pathways. NAD+ levels decline with age.
Research Summary
Animal studies show improved metabolic function, enhanced exercise capacity, and extended healthspan. Human trials demonstrate safety and NAD+ elevation. Long-term benefits in humans still being established. David Sinclair's research popularized the field.
Dosing Information
Typical Dosingⓘ
Community experience
Limited community data available
See research dosing
See research protocols
Research Dosingⓘ
Scientific studies
Doses from research and supplements
Doses from Studies
NMN: 250-1000mg daily
NR: 300-1000mg daily
Duration
Ongoing supplementation
Administration
Oral (capsules, sublingual)
Timing & Administration
Best Time to Take
Morning or before bed
Once daily, consistent timing
Food Recommendation
With or without food
Why This Timing?
Anti-aging peptides can be taken morning for daytime cellular support or evening for overnight repair.
Possible Side Effects
Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.
- ●Generally well-tolerated
- ●Diarrhea (rare)
- ●Nausea (rare)
- ●Skin rashes (rare)
- ●Does NOT cause flushing like niacin
- ●Theoretical cancer concerns with chronic use
- ●NR has GRAS status
References
Related Peptides
Peptides commonly compared with NAD+ Precursors or used in similar applications.
SS-31
Clinical TrialsA mitochondria-targeted peptide that improves cellular energy production. Being developed for heart failure and mitochondrial diseases.
Anti-AgingGlutathione
Clinical TrialsThe body's master antioxidant - a tripeptide composed of glutamate, cysteine, and glycine. Found in every cell at concentrations similar to glucose (5mM). Essential for detoxification, immune function, and cellular protection against oxidative stress.
Anti-AgingDSIP
Clinical TrialsA neuropeptide that promotes deep delta wave sleep. First isolated from rabbit brains in 1977. Used for sleep optimization and stress reduction.
Anti-AgingHumanin
PreclinicalA mitochondria-derived peptide discovered for its neuroprotective effects against Alzheimer's-related toxicity. Being studied for aging and metabolic benefits.
Anti-AgingEpithalon
Clinical TrialsA tetrapeptide studied for its effects on telomerase activation and potential anti-aging properties. Based on research by Professor Vladimir Khavinson.
BioregulatorsMOTS-c
PreclinicalA mitochondria-derived peptide that regulates metabolic homeostasis. Discovered in 2015, it's being studied for its effects on insulin sensitivity, exercise capacity, and aging.
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Educational Information Only
This information is provided for educational purposes only and is not intended as medical advice. Always consult with qualified healthcare providers before making any decisions about peptides or other substances. The protocols listed reflect doses observed in research studies, not recommendations.