NAD+ Precursors
Also known as: NMN, NR, Nicotinamide Riboside, Nicotinamide Mononucleotide
Popular For
Cellular energy, longevity, metabolic health
Key Facts: NAD+ Precursors
- Category
- Anti-Aging
- FDA Status
- Not FDA Approved
- Clinical Status
- Available as supplements - Clinical trials ongoing
- Administration
- Oral (capsules, sublingual)
- Typical Dose
- Limited community data available
- Frequency
- See research protocols
- Evidence Level
- Human Trials
- Duration
- Ongoing supplementation
Mechanism of Action
NMN and NR are converted to NAD+ in cells. NAD+ is essential for mitochondrial function, DNA repair, and sirtuin enzyme activity. Sirtuins regulate metabolism, stress response, and longevity pathways. NAD+ levels decline with age.
Research Summary
Animal studies show improved metabolic function, enhanced exercise capacity, and extended healthspan. Human trials demonstrate safety and NAD+ elevation. Long-term benefits in humans still being established. David Sinclair's research popularized the field.
Dosing Information
Typical Dosingⓘ
Community experience
Limited community data available
See research dosing
See research protocols
Research Dosingⓘ
Scientific studies
Doses from research and supplements
Doses from Studies
NMN: 250-1000mg daily
NR: 300-1000mg daily
Duration
Ongoing supplementation
Administration
Oral (capsules, sublingual)
Timing & Administration
Best Time to Take
Morning or before bed
Once daily, consistent timing
Food Recommendation
With or without food
Why This Timing?
Anti-aging peptides can be taken morning for daytime cellular support or evening for overnight repair.
Possible Side Effects
Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.
- ●Generally well-tolerated
- ●Diarrhea (rare)
- ●Nausea (rare)
- ●Skin rashes (rare)
- ●Does NOT cause flushing like niacin
- ●Theoretical cancer concerns with chronic use
- ●NR has GRAS status
References
Related Peptides
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