Humanin
Also known as: HN, HNG (S14G-humanin)
Key Facts: Humanin
- Category
- Anti-Aging
- FDA Status
- Not FDA Approved
- Clinical Status
- Preclinical - Extensive animal research
- Administration
- Injection (route varies)
- Typical Dose
- 5-10 mg weekly divided into 2-3 injections
- Frequency
- 2-3x weekly (e.g., Monday, Wednesday, Friday)
- Evidence Level
- Animal Studies
- Duration
- Variable
What to Expect
A mitochondria-derived peptide discovered for its neuroprotective effects against Alzheimer's-related toxicity. Being studied for aging and metabolic benefits.
Mechanism of Action
Humanin acts through multiple pathways including STAT3 signaling, binding to IGFBP-3, and activating the FPRL1 receptor. It protects neurons from apoptosis, improves insulin sensitivity, and has anti-inflammatory effects.
Research Summary
Research shows protection against amyloid-beta toxicity in Alzheimer's models. Studies demonstrate improved insulin sensitivity, reduced atherosclerosis in animal models, and potential anti-aging effects. Human studies are limited.
Dosing Information
Note: Animal study doses may not translate directly to humans.
Typical Dosingⓘ
Community experience
5-10 mg weekly divided into 2-3 injections
5-10 mg per week
2-3x weekly (e.g., Monday, Wednesday, Friday)
Subcutaneous injection to abdomen or thigh. Cycle 2-4 weeks on, 2-4 weeks off. Often stacked with MOTS-c and NAD+ for mitochondrial support. Store lyophilized at 0-5°C; reconstituted solution stable 5 days at 4°C or freeze for longer storage.
Research Dosingⓘ
Scientific studies
Doses from research protocols
Doses from Studies
Research varies widely
HNG analogs used at higher doses
Duration
Variable
Administration
Injection (route varies)
Timing & Administration
Best Time to Take
Morning
Once daily
Food Recommendation
With or without food
Why This Timing?
Humanin is a mitochondrial peptide. Morning use supports daytime cellular energy demands.
Possible Side Effects
Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.
- ●Generally well-tolerated (preclinical)
- ●Mild injection site reactions
- ●Potential pro-tumoral effects
- ●May affect glucose metabolism
- ●No human clinical trial data
References
Related Peptides
Peptides commonly compared with Humanin or used in similar applications.
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Anti-AgingNAD+ Precursors
Clinical TrialsWhile not peptides, NAD+ precursors are frequently discussed alongside peptides in longevity circles. They boost cellular NAD+ levels, supporting energy metabolism and sirtuin activity.
Anti-AgingSS-31
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Anti-AgingGHRP-6
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Growth Hormone5-Amino-1MQ
PreclinicalA selective NNMT (nicotinamide N-methyltransferase) inhibitor that enhances cellular energy metabolism. Not a peptide but a small molecule research compound commonly used alongside peptides for fat loss and metabolic support.
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Educational Information Only
This information is provided for educational purposes only and is not intended as medical advice. Always consult with qualified healthcare providers before making any decisions about peptides or other substances. The protocols listed reflect doses observed in research studies, not recommendations.