Humanin
Also known as: HN, HNG (S14G-humanin)
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Humanin from $221/kit
2 verified vendors, ≥99% purity, COAs included.
Key Facts: Humanin
- Category
- Anti-Aging
- FDA Status
- Not FDA Approved
- Clinical Status
- Preclinical - Extensive animal research
- Administration
- Injection (route varies)
- Typical Dose
- 5-10 mg weekly divided into 2-3 injections
- Frequency
- 2-3x weekly (e.g., Monday, Wednesday, Friday)
- Duration
- Variable
Mechanism of Action
Humanin acts through multiple pathways including STAT3 signaling, binding to IGFBP-3, and activating the FPRL1 receptor. It protects neurons from apoptosis, improves insulin sensitivity, and has anti-inflammatory effects.
Research Summary
Research shows protection against amyloid-beta toxicity in Alzheimer's models. Studies demonstrate improved insulin sensitivity, reduced atherosclerosis in animal models, and potential anti-aging effects. Human studies are limited.
Dosing Information
Note: Animal study doses may not translate directly to humans.
Typical Dosingⓘ
Community experience
5-10 mg weekly divided into 2-3 injections
5-10 mg per week
2-3x weekly (e.g., Monday, Wednesday, Friday)
Subcutaneous injection to abdomen or thigh. Cycle 2-4 weeks on, 2-4 weeks off. Often stacked with MOTS-c and NAD+ for mitochondrial support. Store lyophilized at 0-5°C; reconstituted solution stable 5 days at 4°C or freeze for longer storage.
Research Dosingⓘ
Scientific studies
Doses from research protocols
Doses from Studies
Research varies widely
HNG analogs used at higher doses
Duration
Variable
Administration
Injection (route varies)
Timing & Administration
Best Time to Take
Morning
Once daily
Food Recommendation
With or without food
Why This Timing?
Humanin is a mitochondrial peptide. Morning use supports daytime cellular energy demands.
Possible Side Effects
Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.
- ●Generally well-tolerated (preclinical)
- ●Mild injection site reactions
- ●Potential pro-tumoral effects
- ●May affect glucose metabolism
- ●No human clinical trial data
References
- https://pubmed.ncbi.nlm.nih.gov/34626746/
- https://pubmed.ncbi.nlm.nih.gov/12009529/
- https://pubmed.ncbi.nlm.nih.gov/32575074/
Research This Peptide Further
Buy in shop
Humanin from $221/kit
2 verified vendors, ≥99% purity, COAs included.
Frequently Asked Questions
What does Humanin do?
A mitochondria-derived peptide discovered for its neuroprotective effects against Alzheimer's-related toxicity. Being studied for aging and metabolic benefits.
How does Humanin work?
Humanin acts through multiple pathways including STAT3 signaling, binding to IGFBP-3, and activating the FPRL1 receptor. It protects neurons from apoptosis, improves insulin sensitivity, and has anti-inflammatory effects.
Is Humanin FDA approved?
No, Humanin is not currently FDA approved. Current status: Preclinical - Extensive animal research
What are the side effects of Humanin?
Reported side effects include: Generally well-tolerated (preclinical), Mild injection site reactions, Potential pro-tumoral effects, May affect glucose metabolism, No human clinical trial data. Individual responses vary based on dosage, duration, and personal health factors.
What is the typical dose of Humanin?
Community-reported common dose: 5-10 mg weekly divided into 2-3 injections (2-3x weekly (e.g., Monday, Wednesday, Friday)). Range: 5-10 mg per week. Administration: Injection (route varies). Community-reported doses. Not medical advice. Consult healthcare provider.
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