Semax vs Dihexa
Comprehensive side-by-side comparison of mechanisms, dosing, side effects, and research
Also: SEMAX, Heptapeptide SEMAX
A synthetic peptide derived from ACTH (4-10) fragment with added Pro-Gly-Pro sequence. Approved in Russia for stroke and cognitive enhancement. Known for nootropic and neuroprotective effects.
Also: N-hexanoic-Tyr-Ile-(6) aminohexanoic amide
A potent cognitive-enhancing peptide derived from angiotensin IV. Reported to be 10 million times more potent than BDNF at promoting synaptogenesis.
Key Comparison Insights
- Both peptides belong to the Cognitive category, suggesting similar primary applications.
- Semax has stronger research evidence (Human Trials) compared to Dihexa (Animal Studies).
Detailed Comparison
| Attribute | Semax | Dihexa |
|---|---|---|
| Category | Cognitive | Cognitive |
| FDA Status | Not FDA Approved | Not FDA Approved |
| Clinical Status | Pre I II III IV FDA | Pre I II III IV FDA |
| Mechanism of Action | Semax increases BDNF and NGF expression, modulates dopamine and serotonin systems, and has anti-inflammatory effects in the brain. It enhances neuroplasticity and protects neurons from oxidative stress and excitotoxicity. | Dihexa activates hepatocyte growth factor (HGF) signaling through the c-Met receptor. This promotes dendritic spine formation, enhances synaptic connections, and supports neuronal survival. Crosses blood-brain barrier orally. |
| Common Dosing | 200-600 mcg intranasal daily 1-3x daily, intranasal | 5-20 mg oral or sublingual daily Once daily, effects can last up to 10 days |
| Administration | Intranasal spray (most common) | Oral, sublingual, or intranasal |
| Typical Duration | 10-30 days typical | Cycles of 2-4 weeks |
| Best Time to Take | Morning or early afternoon | Morning |
Possible Side Effects May vary by individual |
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| Research Summary | Russian research shows cognitive enhancement, improved memory and attention, and benefits for stroke recovery. Studies demonstrate increased BDNF levels and neuroprotective effects. Used clinically in Russia for stroke, TBI, and cognitive disorders. | Animal studies show remarkable cognitive enhancement and reversal of scopolamine-induced memory deficits. Research demonstrates increased dendritic spine density. Limited human data but significant interest in nootropic community. |
Frequently Asked Questions: Semax vs Dihexa
What is the difference between Semax and Dihexa?
Semax is a cognitive peptide that a synthetic peptide derived from acth (4-10) fragment with added pro-gly-pro sequence. approved in russia for stroke and cognitive enhancement. known for nootropic and neuroprotective effects. Dihexa is a cognitive peptide that a potent cognitive-enhancing peptide derived from angiotensin iv. reported to be 10 million times more potent than bdnf at promoting synaptogenesis. The main differences lie in their mechanisms of action and clinical applications.
Which is better, Semax or Dihexa?
Neither is universally "better" - the choice depends on your specific goals. Semax is typically used for cognitive purposes, while Dihexa is used for cognitive. Always consult with a healthcare provider to determine which may be appropriate for your situation.
Can Semax and Dihexa be used together?
Some peptide protocols combine multiple compounds for synergistic effects. However, using Semax and Dihexa together should only be considered under medical supervision, as both compounds have their own side effect profiles and potential interactions. Research on their combined use may be limited.
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Educational Information Only
This comparison of Semax and Dihexa is for educational purposes only. Neither this comparison nor any information on this site constitutes medical advice. Always consult with qualified healthcare providers before making decisions about peptides or other substances.