Dihexa vs P21
Comprehensive side-by-side comparison of mechanisms, dosing, side effects, and research
Also: N-hexanoic-Tyr-Ile-(6) aminohexanoic amide
A potent cognitive-enhancing peptide derived from angiotensin IV. Reported to be 10 million times more potent than BDNF at promoting synaptogenesis.
Also: P021, Ac-DGGLAG-NH2
A synthetic peptide mimetic of CNTF (ciliary neurotrophic factor) designed for neurodegenerative disease. Promotes neurogenesis and reduces neuroinflammation.
Key Comparison Insights
- Both peptides belong to the Cognitive category, suggesting similar primary applications.
Detailed Comparison
| Attribute | Dihexa | P21 |
|---|---|---|
| Category | Cognitive | Cognitive |
| FDA Status | Not FDA Approved | Not FDA Approved |
| Clinical Status | Pre I II III IV FDA | Pre I II III IV FDA |
| Mechanism of Action | Dihexa activates hepatocyte growth factor (HGF) signaling through the c-Met receptor. This promotes dendritic spine formation, enhances synaptic connections, and supports neuronal survival. Crosses blood-brain barrier orally. | P21 acts as a CNTF small-molecule peptide mimetic. It enhances neurogenesis in the hippocampus, reduces tau phosphorylation, inhibits neuroinflammation, and improves synaptic plasticity. Designed to be orally bioavailable. |
| Common Dosing | 5-20 mg oral or sublingual daily Once daily, effects can last up to 10 days | Limited community data available See research protocols |
| Administration | Oral, sublingual, or intranasal | Oral (nasal in some studies) |
| Typical Duration | Cycles of 2-4 weeks | Ongoing supplementation in studies |
| Best Time to Take | Morning | Morning |
Possible Side Effects May vary by individual |
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| Research Summary | Animal studies show remarkable cognitive enhancement and reversal of scopolamine-induced memory deficits. Research demonstrates increased dendritic spine density. Limited human data but significant interest in nootropic community. | Studies show cognitive improvement in Alzheimer's mouse models. Research demonstrates increased neurogenesis, reduced tau pathology, and improved learning/memory. Being developed for Alzheimer's and age-related cognitive decline. |
Frequently Asked Questions: Dihexa vs P21
What is the difference between Dihexa and P21?
Dihexa is a cognitive peptide that a potent cognitive-enhancing peptide derived from angiotensin iv. reported to be 10 million times more potent than bdnf at promoting synaptogenesis. P21 is a cognitive peptide that a synthetic peptide mimetic of cntf (ciliary neurotrophic factor) designed for neurodegenerative disease. promotes neurogenesis and reduces neuroinflammation. The main differences lie in their mechanisms of action and clinical applications.
Which is better, Dihexa or P21?
Neither is universally "better" - the choice depends on your specific goals. Dihexa is typically used for cognitive purposes, while P21 is used for cognitive. Always consult with a healthcare provider to determine which may be appropriate for your situation.
Can Dihexa and P21 be used together?
Some peptide protocols combine multiple compounds for synergistic effects. However, using Dihexa and P21 together should only be considered under medical supervision, as both compounds have their own side effect profiles and potential interactions. Research on their combined use may be limited.
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Educational Information Only
This comparison of Dihexa and P21 is for educational purposes only. Neither this comparison nor any information on this site constitutes medical advice. Always consult with qualified healthcare providers before making decisions about peptides or other substances.