Selank vs Dihexa
Comprehensive side-by-side comparison of mechanisms, dosing, side effects, and research
Also: Selanc, TP-7
A synthetic peptide derived from tuftsin, an immunomodulatory peptide. Approved in Russia for anxiety and nootropic effects. Known for anxiolytic properties without sedation.
Also: N-hexanoic-Tyr-Ile-(6) aminohexanoic amide
A potent cognitive-enhancing peptide derived from angiotensin IV. Reported to be 10 million times more potent than BDNF at promoting synaptogenesis.
Key Comparison Insights
- Both peptides belong to the Cognitive category, suggesting similar primary applications.
- Selank has stronger research evidence (Human Trials) compared to Dihexa (Animal Studies).
Detailed Comparison
| Attribute | Selank | Dihexa |
|---|---|---|
| Category | Cognitive | Cognitive |
| FDA Status | Not FDA Approved | Not FDA Approved |
| Clinical Status | Pre I II III IV FDA | Pre I II III IV FDA |
| Mechanism of Action | Selank modulates the expression of BDNF (brain-derived neurotrophic factor), influences serotonin and dopamine metabolism, and has effects on the GABAergic system. It also has immunomodulatory properties inherited from its tuftsin backbone. | Dihexa activates hepatocyte growth factor (HGF) signaling through the c-Met receptor. This promotes dendritic spine formation, enhances synaptic connections, and supports neuronal survival. Crosses blood-brain barrier orally. |
| Common Dosing | 250-500 mcg intranasal 2-3x daily 2-3x daily, intranasal | 5-20 mg oral or sublingual daily Once daily, effects can last up to 10 days |
| Administration | Intranasal spray (most common), subcutaneous injection | Oral, sublingual, or intranasal |
| Typical Duration | 14-21 days typical | Cycles of 2-4 weeks |
| Best Time to Take | Morning or as needed for anxiety | Morning |
Possible Side Effects May vary by individual |
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| Research Summary | Russian clinical trials demonstrate anxiolytic effects comparable to benzodiazepines without sedation or addiction potential. Studies show improved cognitive function under stress, enhanced memory, and stabilization of mood. | Animal studies show remarkable cognitive enhancement and reversal of scopolamine-induced memory deficits. Research demonstrates increased dendritic spine density. Limited human data but significant interest in nootropic community. |
Frequently Asked Questions: Selank vs Dihexa
What is the difference between Selank and Dihexa?
Selank is a cognitive peptide that a synthetic peptide derived from tuftsin, an immunomodulatory peptide. approved in russia for anxiety and nootropic effects. known for anxiolytic properties without sedation. Dihexa is a cognitive peptide that a potent cognitive-enhancing peptide derived from angiotensin iv. reported to be 10 million times more potent than bdnf at promoting synaptogenesis. The main differences lie in their mechanisms of action and clinical applications.
Which is better, Selank or Dihexa?
Neither is universally "better" - the choice depends on your specific goals. Selank is typically used for cognitive purposes, while Dihexa is used for cognitive. Always consult with a healthcare provider to determine which may be appropriate for your situation.
Can Selank and Dihexa be used together?
Some peptide protocols combine multiple compounds for synergistic effects. However, using Selank and Dihexa together should only be considered under medical supervision, as both compounds have their own side effect profiles and potential interactions. Research on their combined use may be limited.
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Educational Information Only
This comparison of Selank and Dihexa is for educational purposes only. Neither this comparison nor any information on this site constitutes medical advice. Always consult with qualified healthcare providers before making decisions about peptides or other substances.