Semax vs Selank
Comprehensive side-by-side comparison of mechanisms, dosing, side effects, and research
Also: SEMAX, Heptapeptide SEMAX
A synthetic peptide derived from ACTH (4-10) fragment with added Pro-Gly-Pro sequence. Approved in Russia for stroke and cognitive enhancement. Known for nootropic and neuroprotective effects.
Also: Selanc, TP-7
A synthetic peptide derived from tuftsin, an immunomodulatory peptide. Approved in Russia for anxiety and nootropic effects. Known for anxiolytic properties without sedation.
Key Comparison Insights
- Both peptides belong to the Cognitive category, suggesting similar primary applications.
Detailed Comparison
| Attribute | Semax | Selank |
|---|---|---|
| Category | Cognitive | Cognitive |
| FDA Status | Not FDA Approved | Not FDA Approved |
| Clinical Status | Pre I II III IV FDA | Pre I II III IV FDA |
| Mechanism of Action | Semax increases BDNF and NGF expression, modulates dopamine and serotonin systems, and has anti-inflammatory effects in the brain. It enhances neuroplasticity and protects neurons from oxidative stress and excitotoxicity. | Selank modulates the expression of BDNF (brain-derived neurotrophic factor), influences serotonin and dopamine metabolism, and has effects on the GABAergic system. It also has immunomodulatory properties inherited from its tuftsin backbone. |
| Common Dosing | 200-600 mcg intranasal daily 1-3x daily, intranasal | 250-500 mcg intranasal 2-3x daily 2-3x daily, intranasal |
| Administration | Intranasal spray (most common) | Intranasal spray (most common), subcutaneous injection |
| Typical Duration | 10-30 days typical | 14-21 days typical |
| Best Time to Take | Morning or early afternoon | Morning or as needed for anxiety |
Possible Side Effects May vary by individual |
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| Research Summary | Russian research shows cognitive enhancement, improved memory and attention, and benefits for stroke recovery. Studies demonstrate increased BDNF levels and neuroprotective effects. Used clinically in Russia for stroke, TBI, and cognitive disorders. | Russian clinical trials demonstrate anxiolytic effects comparable to benzodiazepines without sedation or addiction potential. Studies show improved cognitive function under stress, enhanced memory, and stabilization of mood. |
Frequently Asked Questions: Semax vs Selank
What is the difference between Semax and Selank?
Semax is a cognitive peptide that a synthetic peptide derived from acth (4-10) fragment with added pro-gly-pro sequence. approved in russia for stroke and cognitive enhancement. known for nootropic and neuroprotective effects. Selank is a cognitive peptide that a synthetic peptide derived from tuftsin, an immunomodulatory peptide. approved in russia for anxiety and nootropic effects. known for anxiolytic properties without sedation. The main differences lie in their mechanisms of action and clinical applications.
Which is better, Semax or Selank?
Neither is universally "better" - the choice depends on your specific goals. Semax is typically used for cognitive purposes, while Selank is used for cognitive. Always consult with a healthcare provider to determine which may be appropriate for your situation.
Can Semax and Selank be used together?
Some peptide protocols combine multiple compounds for synergistic effects. However, using Semax and Selank together should only be considered under medical supervision, as both compounds have their own side effect profiles and potential interactions. Research on their combined use may be limited.
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Educational Information Only
This comparison of Semax and Selank is for educational purposes only. Neither this comparison nor any information on this site constitutes medical advice. Always consult with qualified healthcare providers before making decisions about peptides or other substances.