GHRP-6
Also known as: Growth Hormone Releasing Peptide 6, SKF-110679
Key Facts: GHRP-6
- Category
- Growth Hormone
- FDA Status
- Not FDA Approved
- Clinical Status
- Preclinical/Investigational - Extensive research history
- Administration
- Subcutaneous injection, ideally fasted
- Typical Dose
- 100-300 mcg 2-3x daily
- Frequency
- 2-3x daily
- Evidence Level
- Human Trials
- Duration
- 8-12 weeks
What to Expect
One of the first synthetic GH secretagogues developed. Strongly stimulates GH release and significantly increases appetite through ghrelin receptor activation.
Mechanism of Action
GHRP-6 binds to ghrelin receptors (GHSR-1a) in the hypothalamus and pituitary, triggering a strong GH release. It also activates the hunger-signaling pathway, leading to significant appetite increase. Stimulates cortisol and prolactin more than newer GHRPs.
Research Summary
Well-studied peptide showing reliable GH release. Research demonstrates cardioprotective effects in animal models, improved wound healing, and significant appetite stimulation. Studies show 3-6 fold increase in GH levels.
Dosing Information
Typical Dosingⓘ
Community experience
100-300 mcg 2-3x daily
100-500 mcg per dose
2-3x daily
Causes significant hunger increase. Take on empty stomach. Often used for appetite stimulation and GH release.
Research Dosingⓘ
Scientific studies
Doses observed in research studies
Doses from Studies
100-300 mcg per injection
Usually 2-3x daily
Duration
8-12 weeks
Administration
Subcutaneous injection, ideally fasted
Timing & Administration
Best Time to Take
Before bed or morning (fasted)
2-3 times daily, 30 min before meals or before bed
Food Recommendation
Take on empty stomach
Why This Timing?
GHRP-6 stimulates GH release and increases appetite. Take fasted for maximum GH response. Evening dose supports natural nighttime GH surge.
Possible Side Effects
Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.
- ●Significant hunger increase (most pronounced of all GHRPs)
- ●Water retention
- ●Elevated cortisol levels
- ●Elevated prolactin levels
- ●Flushing
- ●Nausea
- ●Headache
- ●May trigger histamine release - use caution with MCAS or histamine sensitivity
- ●Limited long-term safety data
References
Related Peptides
Peptides commonly compared with GHRP-6 or used in similar applications.
GHRP-2
Clinical TrialsA synthetic hexapeptide that potently stimulates GH release. More potent than GHRP-6 with less appetite stimulation, but still elevates cortisol and prolactin.
Growth HormoneIpamorelin
Clinical TrialsA selective growth hormone secretagogue that stimulates GH release without significantly affecting cortisol or prolactin. Considered one of the safest GHRPs.
Growth HormoneCJC-1295
Clinical TrialsA synthetic analog of growth hormone-releasing hormone (GHRH) that stimulates GH release from the pituitary. Often combined with a GHRP like Ipamorelin for synergistic effects.
Growth HormoneMK-677
Clinical TrialsAn orally active growth hormone secretagogue that mimics ghrelin. Not a peptide technically, but frequently discussed alongside GH peptides due to similar effects.
Growth HormoneTesamorelin
FDAAn FDA-approved GHRH analog used to reduce excess abdominal fat in HIV-infected patients with lipodystrophy. One of the few peptides with FDA approval.
Growth HormoneSermorelin
PreclinicalA truncated analog of natural GHRH containing the first 29 amino acids. Previously FDA-approved for pediatric GH deficiency, now used off-label for adult hormone optimization.
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Educational Information Only
This information is provided for educational purposes only and is not intended as medical advice. Always consult with qualified healthcare providers before making any decisions about peptides or other substances. The protocols listed reflect doses observed in research studies, not recommendations.