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Skin & Hair

Snap-8

Also known as: Acetyl Octapeptide-3, SNAP-8

Research
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Key Facts: Snap-8

Category
Skin & Hair
FDA Status
Not FDA Approved
Clinical Status
Cosmetic use - Widely available in skincare
Administration
Topical (serums, creams)
Typical Dose
Limited community data available
Frequency
See research protocols
Evidence Level
Limited Research
Duration
Ongoing use for maintained effects
Also Known As
Acetyl Octapeptide-3, SNAP-8

What to Expect

A cosmetic peptide that reduces wrinkles by inhibiting muscle contraction. Often called 'Botox in a bottle' though mechanism differs from actual botulinum toxin.

Mechanism of Action

Snap-8 is a fragment of SNAP-25 that interferes with SNARE complex formation needed for neurotransmitter release. By competing with native SNAP-25, it reduces acetylcholine release at the neuromuscular junction, decreasing muscle contraction.

Research Summary

Studies show reduction in wrinkle depth with topical application. Research demonstrates up to 63% reduction in wrinkle depth over 28 days. Works synergistically with other cosmetic peptides. Well-established in skincare formulations.

Clinical Status:Cosmetic use - Widely available in skincare
Trial Progress:Preclinical
Pre
I
II
III
IV
FDA

Dosing Information

Limited Research·Limited formal studies available

Typical Dosingⓘ

Community experience

Common Dose

Limited community data available

Range

See research dosing

Frequency

See research protocols

Research Dosingⓘ

Scientific studies

Cosmetic application guidelines

Doses from Studies

Duration

Ongoing use for maintained effects

Administration

Topical (serums, creams)

Timing & Administration

Best Time to Take

Evening (topical)

Once or twice daily topically

Food Recommendation

With or without food

Why This Timing?

SNAP-8 is used topically for wrinkles. Evening application allows overnight absorption.

Possible Side Effects

Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.

  • ●Generally very well-tolerated
  • ●Mild tingling (first applications)
  • ●Mild skin irritation (high concentrations)
  • ●No systemic toxicity

References

Related Peptides

Peptides commonly compared with Snap-8 or used in similar applications.

GHK-Cu

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A naturally occurring copper-binding peptide found in human plasma, saliva, and urine. Widely used in skincare for its wound healing and anti-aging properties.

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Argireline

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A popular cosmetic peptide that reduces facial wrinkles by inhibiting neurotransmitter release. One of the most widely used peptides in anti-aging skincare.

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Matrixyl

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A collagen-stimulating peptide widely used in anti-aging skincare. One of the first peptides proven to reduce wrinkles by stimulating collagen synthesis.

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Matrixyl 3000

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An advanced version of Matrixyl combining two peptides for enhanced anti-aging effects. Targets both collagen production and inflammation.

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Copper Peptide AHK-Cu

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A copper-binding tripeptide primarily used for hair growth stimulation. Shows promise for both hair loss prevention and scalp health.

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Melanotan I

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A 13-amino acid synthetic analog of α-MSH that stimulates melanin production. FDA-approved (as Scenesse) for treating phototoxicity in patients with erythropoietic protoporphyria (EPP). More selective than Melanotan II with fewer side effects.

Skin & Hair
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Educational Information Only

This information is provided for educational purposes only and is not intended as medical advice. Always consult with qualified healthcare providers before making any decisions about peptides or other substances. The protocols listed reflect doses observed in research studies, not recommendations.

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