Matrixyl
Also known as: Palmitoyl Pentapeptide-4, Pal-KTTKS
Key Facts: Matrixyl
- Category
- Skin & Hair
- FDA Status
- Not FDA Approved
- Clinical Status
- Cosmetic use - Extensively studied
- Administration
- Topical (serums, creams)
- Typical Dose
- Limited community data available
- Frequency
- See research protocols
- Evidence Level
- Limited Research
- Duration
- 8-12 weeks for visible results, ongoing use
What to Expect
A collagen-stimulating peptide widely used in anti-aging skincare. One of the first peptides proven to reduce wrinkles by stimulating collagen synthesis.
Mechanism of Action
Matrixyl is a lipopeptide that signals to fibroblasts to produce more collagen and other extracellular matrix proteins. The palmitoyl chain enhances skin penetration. It mimics collagen breakdown products that trigger repair mechanisms.
Research Summary
Clinical studies show significant reduction in wrinkle depth and volume. Research demonstrates increased collagen I, III, and IV production. One of the most clinically validated cosmetic peptides with double-blind trials.
Dosing Information
Typical Dosingⓘ
Community experience
Limited community data available
See research dosing
See research protocols
Research Dosingⓘ
Scientific studies
Cosmetic application guidelines
Doses from Studies
3-8% in formulations
Applied twice daily
Duration
8-12 weeks for visible results, ongoing use
Administration
Topical (serums, creams)
Timing & Administration
Best Time to Take
Morning or as directed
Follow recommended protocol
Food Recommendation
With or without food
Why This Timing?
Timing may vary based on individual response and goals. Consistency is generally more important than specific timing.
Possible Side Effects
Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.
- ●Generally very well-tolerated
- ●Redness (rare)
- ●Itching (rare)
- ●Minimal systemic absorption
References
Related Peptides
Peptides commonly compared with Matrixyl or used in similar applications.
GHK-Cu
ResearchA naturally occurring copper-binding peptide found in human plasma, saliva, and urine. Widely used in skincare for its wound healing and anti-aging properties.
Skin & HairMatrixyl 3000
ResearchAn advanced version of Matrixyl combining two peptides for enhanced anti-aging effects. Targets both collagen production and inflammation.
Skin & HairCopper Peptide AHK-Cu
ResearchA copper-binding tripeptide primarily used for hair growth stimulation. Shows promise for both hair loss prevention and scalp health.
Skin & HairMelanotan I
FDAA 13-amino acid synthetic analog of α-MSH that stimulates melanin production. FDA-approved (as Scenesse) for treating phototoxicity in patients with erythropoietic protoporphyria (EPP). More selective than Melanotan II with fewer side effects.
Skin & HairSnap-8
ResearchA cosmetic peptide that reduces wrinkles by inhibiting muscle contraction. Often called 'Botox in a bottle' though mechanism differs from actual botulinum toxin.
Skin & HairArgireline
ResearchA popular cosmetic peptide that reduces facial wrinkles by inhibiting neurotransmitter release. One of the most widely used peptides in anti-aging skincare.
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Educational Information Only
This information is provided for educational purposes only and is not intended as medical advice. Always consult with qualified healthcare providers before making any decisions about peptides or other substances. The protocols listed reflect doses observed in research studies, not recommendations.