Argireline
Also known as: Acetyl Hexapeptide-3, Acetyl Hexapeptide-8
Key Facts: Argireline
- Category
- Skin & Hair
- FDA Status
- Not FDA Approved
- Clinical Status
- Cosmetic use - Widely available
- Administration
- Topical (serums, creams)
- Typical Dose
- Limited community data available
- Frequency
- See research protocols
- Evidence Level
- Limited Research
- Duration
- Ongoing use for maintained effects
What to Expect
A popular cosmetic peptide that reduces facial wrinkles by inhibiting neurotransmitter release. One of the most widely used peptides in anti-aging skincare.
Mechanism of Action
Argireline mimics the N-terminal of SNAP-25 protein, inhibiting SNARE complex formation necessary for muscle contraction. This reduces facial muscle movement and subsequently wrinkle formation, similar to but milder than botulinum toxin.
Research Summary
Studies demonstrate 30% reduction in wrinkle depth after 30 days of use. Research shows effectiveness particularly for expression lines around eyes and forehead. Well-established safety profile with decades of cosmetic use.
Dosing Information
Typical Dosingⓘ
Community experience
Limited community data available
See research dosing
See research protocols
Research Dosingⓘ
Scientific studies
Cosmetic application guidelines
Doses from Studies
5-10% concentration in formulations
Applied twice daily
Duration
Ongoing use for maintained effects
Administration
Topical (serums, creams)
Timing & Administration
Best Time to Take
Morning and evening (topical)
Twice daily topically
Food Recommendation
With or without food
Why This Timing?
Argireline is a topical anti-wrinkle peptide. Twice daily application maintains effects.
Possible Side Effects
Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.
- ●Generally very safe
- ●Mild skin irritation (rare)
- ●Redness or tingling (rare)
- ●Much fewer side effects than botulinum toxin
References
Related Peptides
Peptides commonly compared with Argireline or used in similar applications.
GHK-Cu
ResearchA naturally occurring copper-binding peptide found in human plasma, saliva, and urine. Widely used in skincare for its wound healing and anti-aging properties.
Skin & HairSnap-8
ResearchA cosmetic peptide that reduces wrinkles by inhibiting muscle contraction. Often called 'Botox in a bottle' though mechanism differs from actual botulinum toxin.
Skin & HairMatrixyl
ResearchA collagen-stimulating peptide widely used in anti-aging skincare. One of the first peptides proven to reduce wrinkles by stimulating collagen synthesis.
Skin & HairMatrixyl 3000
ResearchAn advanced version of Matrixyl combining two peptides for enhanced anti-aging effects. Targets both collagen production and inflammation.
Skin & HairCopper Peptide AHK-Cu
ResearchA copper-binding tripeptide primarily used for hair growth stimulation. Shows promise for both hair loss prevention and scalp health.
Skin & HairMelanotan I
FDAA 13-amino acid synthetic analog of α-MSH that stimulates melanin production. FDA-approved (as Scenesse) for treating phototoxicity in patients with erythropoietic protoporphyria (EPP). More selective than Melanotan II with fewer side effects.
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Educational Information Only
This information is provided for educational purposes only and is not intended as medical advice. Always consult with qualified healthcare providers before making any decisions about peptides or other substances. The protocols listed reflect doses observed in research studies, not recommendations.