Matrixyl 3000
Also known as: Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7
Key Facts: Matrixyl 3000
- Category
- Skin & Hair
- FDA Status
- Not FDA Approved
- Clinical Status
- Cosmetic use - Widely available
- Administration
- Topical (serums, creams)
- Typical Dose
- Limited community data available
- Frequency
- See research protocols
- Evidence Level
- Limited Research
- Duration
- Ongoing use for maintained effects
What to Expect
An advanced version of Matrixyl combining two peptides for enhanced anti-aging effects. Targets both collagen production and inflammation.
Mechanism of Action
Combines Pal-GHK (collagen synthesis) with Pal-GQPR (anti-inflammatory). The dual action stimulates new collagen production while reducing inflammation that accelerates aging. Works synergistically with better results than either peptide alone.
Research Summary
Studies show superior wrinkle reduction compared to original Matrixyl. Research demonstrates reduced inflammatory markers along with increased collagen. Clinical trials show improvement in skin firmness and elasticity.
Dosing Information
Typical Dosingⓘ
Community experience
Limited community data available
See research dosing
See research protocols
Research Dosingⓘ
Scientific studies
Cosmetic application guidelines
Doses from Studies
2-8% in formulations
Applied twice daily
Duration
Ongoing use for maintained effects
Administration
Topical (serums, creams)
Timing & Administration
Best Time to Take
Morning or as directed
Follow recommended protocol
Food Recommendation
With or without food
Why This Timing?
Timing may vary based on individual response and goals. Consistency is generally more important than specific timing.
Possible Side Effects
Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.
- ●Generally very well-tolerated
- ●Temporary stinging (first week)
- ●May trigger breakouts in acne-prone skin
- ●Avoid mixing with strong acids
References
Related Peptides
Peptides commonly compared with Matrixyl 3000 or used in similar applications.
GHK-Cu
ResearchA naturally occurring copper-binding peptide found in human plasma, saliva, and urine. Widely used in skincare for its wound healing and anti-aging properties.
Skin & HairMatrixyl
ResearchA collagen-stimulating peptide widely used in anti-aging skincare. One of the first peptides proven to reduce wrinkles by stimulating collagen synthesis.
Skin & HairCopper Peptide AHK-Cu
ResearchA copper-binding tripeptide primarily used for hair growth stimulation. Shows promise for both hair loss prevention and scalp health.
Skin & HairMelanotan I
FDAA 13-amino acid synthetic analog of α-MSH that stimulates melanin production. FDA-approved (as Scenesse) for treating phototoxicity in patients with erythropoietic protoporphyria (EPP). More selective than Melanotan II with fewer side effects.
Skin & HairSnap-8
ResearchA cosmetic peptide that reduces wrinkles by inhibiting muscle contraction. Often called 'Botox in a bottle' though mechanism differs from actual botulinum toxin.
Skin & HairArgireline
ResearchA popular cosmetic peptide that reduces facial wrinkles by inhibiting neurotransmitter release. One of the most widely used peptides in anti-aging skincare.
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Educational Information Only
This information is provided for educational purposes only and is not intended as medical advice. Always consult with qualified healthcare providers before making any decisions about peptides or other substances. The protocols listed reflect doses observed in research studies, not recommendations.