How to Use Semax
Complete guide to Semax dosing, administration, timing, and protocol recommendations.
Quick Overview
Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) developed in Russia in the 1980s as an analog of the ACTH(4-10) fragment, with a Pro-Gly-Pro tail added to resist breakdown. It is researched and used as a neuroprotective and nootropic agent, typically intranasally, and keeps the cognitive and neurotrophic effects of the ACTH fragment without the parent hormone's cortisol-raising activity. It is used clinically and registered in Russia (including for ischemic stroke and cognitive disorders) but is not approved by the FDA or EMA, and Western evidence is limited.
Dosing Guidelines
Common Dose
200-600 mcg intranasal daily
Frequency
1-3x daily, intranasal
Dose Range
100-900 mcg daily
Note: Nootropic peptide, used intranasally. Effects are subtle and cognitive. Can be combined with Selank for anxiety/focus.
Administration Method
Intranasal spray (most common)
Best Time to Take
Morning or early afternoon
Semax has stimulating cognitive effects. Morning use maximizes focus benefits during work hours without affecting sleep.
Protocol Duration
10-30 days typical
Possible Side Effects
Not everyone experiences these. Individual responses vary.
- •Nasal irritation (common)
- •Headache
- •Insomnia
- •Increased anxiety (paradoxical in some)
- •Nausea
Frequently Asked Questions
What is the recommended dose for Semax?
200-600 mcg intranasal daily
How do you administer Semax?
Intranasal spray (most common)
When is the best time to take Semax?
Morning or early afternoon
How long should you use Semax?
10-30 days typical
This information is for educational purposes only. Always consult with a healthcare professional before using any peptide. Dosing information is based on research literature and community reports, not medical advice.