LL-37
Also known as: Cathelicidin, CAP18
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LL-37 from $96/kit
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Key Facts: LL-37
- Category
- Immune
- FDA Status
- Not FDA Approved
- Clinical Status
- Investigational - Clinical trials for wound healing. FDA Category 2 (restricted; expected to remain restricted due to limited safety data and immunogenicity concerns)
- Administration
- Subcutaneous injection or topical
- Typical Dose
- 100-200 mcg daily
- Frequency
- Once daily
- Duration
- Variable by protocol
Mechanism of Action
LL-37 directly kills bacteria, fungi, and some viruses by disrupting their cell membranes. It also modulates the immune response, promotes wound healing, reduces inflammation, and has anti-biofilm activity against bacterial infections.
Research Summary
Research demonstrates broad antimicrobial activity including against antibiotic-resistant bacteria. Studies show wound healing benefits, anti-biofilm effects, and immune modulation. Being investigated for chronic infections and wound healing applications.
Dosing Information
Typical Dosingⓘ
Community experience
100-200 mcg daily
50-300 mcg daily
Once daily
Antimicrobial peptide. Used for infections, biofilm disruption. Some use higher doses for acute infections.
Research Dosingⓘ
Scientific studies
Doses from research protocols
Doses from Studies
100-200 mcg subcutaneous
Varies by indication
Duration
Variable by protocol
Administration
Subcutaneous injection or topical
Timing & Administration
Best Time to Take
Morning
As directed, typically once daily
Food Recommendation
With or without food
Why This Timing?
LL-37 is an antimicrobial peptide. Morning use supports daytime immune surveillance.
Possible Side Effects
Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.
- ●Injection site reactions (common)
- ●Skin toxicity (ulcers, burning)
- ●Allergic reactions
- ●May trigger histamine release - use caution with MCAS or histamine sensitivity
- ●May contribute to autoimmune conditions
- ●High-dose toxicity concerns
- ●Limited long-term safety data
References
- https://pubmed.ncbi.nlm.nih.gov/20049649/
- https://pubmed.ncbi.nlm.nih.gov/16716248/
- https://pubmed.ncbi.nlm.nih.gov/23840194/
Research This Peptide Further
Buy in shop
LL-37 from $96/kit
3 verified vendors, ≥99% purity, COAs included.
Frequently Asked Questions
What does LL-37 do?
A naturally occurring antimicrobial peptide and the only human cathelicidin. Part of the innate immune system with broad-spectrum antimicrobial activity.
How does LL-37 work?
LL-37 directly kills bacteria, fungi, and some viruses by disrupting their cell membranes. It also modulates the immune response, promotes wound healing, reduces inflammation, and has anti-biofilm activity against bacterial infections.
Is LL-37 FDA approved?
No, LL-37 is not currently FDA approved. Current status: Investigational - Clinical trials for wound healing. FDA Category 2 (restricted; expected to remain restricted due to limited safety data and immunogenicity concerns)
What are the side effects of LL-37?
Reported side effects include: Injection site reactions (common), Skin toxicity (ulcers, burning), Allergic reactions, May trigger histamine release - use caution with MCAS or histamine sensitivity, May contribute to autoimmune conditions. Individual responses vary based on dosage, duration, and personal health factors.
What is the typical dose of LL-37?
Community-reported common dose: 100-200 mcg daily (Once daily). Range: 50-300 mcg daily. Administration: Subcutaneous injection or topical. Community-reported doses. Not medical advice. Consult healthcare provider.
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