Peptibase
Immune

Thymosin Alpha-1

Also known as: Ta1, Zadaxin

Clinical Trials
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Popular For

Immune support, chronic infections, cancer adjunct

Key Facts: Thymosin Alpha-1

Category
Immune
FDA Status
Not FDA Approved
Clinical Status
Approved in 35+ countries - Not FDA approved in US
Administration
Subcutaneous injection
Typical Dose
1.6 mg twice weekly
Frequency
2-3x weekly
Evidence Level
Human Trials
Duration
6-12 months for hepatitis
Also Known As
Ta1, Zadaxin

Mechanism of Action

Thymosin Alpha-1 modulates T-cell function, enhances dendritic cell maturation, and promotes Th1 immune responses. It increases IL-2, interferon-alpha, and interferon-gamma production while reducing inflammatory cytokines.

Research Summary

Approved internationally for chronic hepatitis B and C. Studies show improved outcomes when combined with chemotherapy for cancer. Research demonstrates benefits in sepsis, immunodeficiency, and vaccine response enhancement.

Clinical Status:Approved in 35+ countries - Not FDA approved in US
Trial Progress:FDA Approved
Pre
I
II
III
IV
FDA

Dosing Information

Human Trials·Human studies conducted, not FDA approved

Typical Dosingⓘ

Community experience

Common Dose

1.6 mg twice weekly

Range

0.8-3.2 mg per dose

Frequency

2-3x weekly

Immune modulator. FDA-approved (as Zadaxin) in some countries. Used for immune support and chronic infections.

Research Dosingⓘ

Scientific studies

Doses from clinical practice

Duration

6-12 months for hepatitis

Administration

Subcutaneous injection

Timing & Administration

Best Time to Take

Morning

2-3 times per week

Food Recommendation

With or without food

Why This Timing?

Thymosin Alpha-1 modulates immune function. Morning dosing aligns with natural immune rhythm.

Possible Side Effects

Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.

  • ●Very favorable safety profile
  • ●Injection site reactions (most common)
  • ●Mild fatigue
  • ●Headache
  • ●Rare allergic reactions
  • ●Contraindicated in immunosuppressed transplant patients
  • ●Approved in multiple countries

References

Related Peptides

Peptides commonly compared with Thymosin Alpha-1 or used in similar applications.

LL-37

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A naturally occurring antimicrobial peptide and the only human cathelicidin. Part of the innate immune system with broad-spectrum antimicrobial activity.

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Thymalin

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A thymic peptide complex used in Russia for immune enhancement and anti-aging. Part of Professor Khavinson's bioregulator peptide research.

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KPV

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A tripeptide derived from alpha-melanocyte stimulating hormone (α-MSH). Known for potent anti-inflammatory effects, particularly in the gut.

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VIP

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A naturally occurring peptide with immunomodulatory and anti-inflammatory effects. Being studied for ARDS, pulmonary hypertension, and autoimmune conditions.

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Thymogen

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A synthetic dipeptide (Glu-Trp) bioregulator derived from Thymalin, a thymus extract. One of Professor Khavinson's key immunomodulatory peptides, shown to stimulate T-lymphocyte development and normalize immune function. Has been used clinically in Russia for immune support.

Immune

Enfuvirtide

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A peptide HIV fusion inhibitor that blocks viral entry into cells. First approved drug in the fusion inhibitor class.

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