Thymosin Alpha-1
Also known as: Ta1, Zadaxin
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Key Facts: Thymosin Alpha-1
- Category
- Immune
- FDA Status
- Not FDA Approved
- Clinical Status
- Approved in 30+ countries (as Zadaxin) - Not FDA approved. Has FDA orphan drug designation. Expected return to Category 1 compounding status (2026).
- Administration
- Subcutaneous injection
- Typical Dose
- 1.6 mg twice weekly
- Frequency
- 2-3x weekly
- Duration
- 6-12 months for hepatitis
Mechanism of Action
Thymosin Alpha-1 modulates T-cell function, enhances dendritic cell maturation, and promotes Th1 immune responses. It increases IL-2, interferon-alpha, and interferon-gamma production while reducing inflammatory cytokines.
Research Summary
Approved internationally for chronic hepatitis B and C. Studies show improved outcomes when combined with chemotherapy for cancer. Research demonstrates benefits in sepsis, immunodeficiency, and vaccine response enhancement.
Dosing Information
Typical Dosingⓘ
Community experience
1.6 mg twice weekly
0.8-3.2 mg per dose
2-3x weekly
Immune modulator. FDA-approved (as Zadaxin) in some countries. Used for immune support and chronic infections.
Research Dosingⓘ
Scientific studies
Doses from clinical practice
Doses from Studies
1.6 mg twice weekly
3.2 mg weekly
Duration
6-12 months for hepatitis
Administration
Subcutaneous injection
Timing & Administration
Best Time to Take
Morning
2-3 times per week
Food Recommendation
With or without food
Why This Timing?
Thymosin Alpha-1 modulates immune function. Morning dosing aligns with natural immune rhythm.
Possible Side Effects
Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.
- ●Very favorable safety profile
- ●Injection site reactions (most common)
- ●Mild fatigue
- ●Headache
- ●Rare allergic reactions
- ●Contraindicated in immunosuppressed transplant patients
- ●Approved in multiple countries
References
- https://pubmed.ncbi.nlm.nih.gov/33362999/
- https://pubmed.ncbi.nlm.nih.gov/27450734/
- https://pubmed.ncbi.nlm.nih.gov/20536460/
Research This Peptide Further
Buy in shop
Thymosin Alpha-1 from $62/kit
3 verified vendors, ≥99% purity, COAs included.
Frequently Asked Questions
What does Thymosin Alpha-1 do?
A naturally occurring thymic peptide that enhances immune function. Approved in over 35 countries for hepatitis B/C and as an immune adjuvant.
How does Thymosin Alpha-1 work?
Thymosin Alpha-1 modulates T-cell function, enhances dendritic cell maturation, and promotes Th1 immune responses. It increases IL-2, interferon-alpha, and interferon-gamma production while reducing inflammatory cytokines.
Is Thymosin Alpha-1 FDA approved?
No, Thymosin Alpha-1 is not currently FDA approved. Current status: Approved in 30+ countries (as Zadaxin) - Not FDA approved. Has FDA orphan drug designation. Expected return to Category 1 compounding status (2026).
What are the side effects of Thymosin Alpha-1?
Reported side effects include: Very favorable safety profile, Injection site reactions (most common), Mild fatigue, Headache, Rare allergic reactions. Individual responses vary based on dosage, duration, and personal health factors.
What is the typical dose of Thymosin Alpha-1?
Community-reported common dose: 1.6 mg twice weekly (2-3x weekly). Range: 0.8-3.2 mg per dose. Administration: Subcutaneous injection. Community-reported doses. Not medical advice. Consult healthcare provider.
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