VIP
Also known as: Vasoactive Intestinal Peptide, Aviptadil
Key Facts: VIP
- Category
- Immune
- FDA Status
- Not FDA Approved
- Clinical Status
- Clinical Trials - Multiple indications
- Administration
- IV infusion, inhaled, or intranasal
- Typical Dose
- 50-100 mcg intranasal daily
- Frequency
- 1-2x daily, intranasal
- Evidence Level
- Human Trials
- Duration
- Variable by indication
What to Expect
A naturally occurring peptide with immunomodulatory and anti-inflammatory effects. Being studied for ARDS, pulmonary hypertension, and autoimmune conditions.
Mechanism of Action
VIP binds to VPAC1 and VPAC2 receptors, triggering anti-inflammatory cascades. It relaxes smooth muscle, vasodilates, inhibits pro-inflammatory cytokines, and promotes regulatory T-cell function. Has broad immunomodulatory effects.
Research Summary
Clinical trials for COVID-19 ARDS showed promising results. Research demonstrates benefits in pulmonary arterial hypertension. Studies show potential for autoimmune conditions like rheumatoid arthritis and inflammatory bowel disease.
Dosing Information
Typical Dosingⓘ
Community experience
50-100 mcg intranasal daily
25-150 mcg daily
1-2x daily, intranasal
Vasoactive intestinal peptide. Used for CIRS/mold illness. Intranasal delivery. Requires proper diagnosis first.
Research Dosingⓘ
Scientific studies
Doses from clinical trials
Doses from Studies
50-100 mcg IV for acute conditions
Inhaled formulations studied
Duration
Variable by indication
Administration
IV infusion, inhaled, or intranasal
Timing & Administration
Best Time to Take
Morning or as directed
As prescribed
Food Recommendation
With or without food
Why This Timing?
VIP (Vasoactive Intestinal Peptide) affects multiple systems. Timing based on treatment goals.
Possible Side Effects
Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.
- ●Nausea and diarrhea
- ●Injection site reactions
- ●Headache
- ●Dizziness
- ●Facial flushing
- ●Blood pressure decrease
- ●Short-lived effects due to instability
References
Related Peptides
Peptides commonly compared with VIP or used in similar applications.
LL-37
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ImmuneThymosin Alpha-1
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ImmuneKPV
PreclinicalA tripeptide derived from alpha-melanocyte stimulating hormone (α-MSH). Known for potent anti-inflammatory effects, particularly in the gut.
ImmuneEnfuvirtide
FDAA peptide HIV fusion inhibitor that blocks viral entry into cells. First approved drug in the fusion inhibitor class.
ImmuneTB-500
Clinical TrialsA synthetic 17-amino acid fragment of Thymosin Beta-4 (TB-4). NOT the same as TB-4 - TB-500 has a longer half-life (~2-4 days vs ~2 hours) and is the active region responsible for tissue repair and cell migration. Note: Many vendors mislabel TB-4 as 'TB-500' in premixed products.
HealingKLOW Blend
PreclinicalAn advanced multi-peptide blend combining BPC-157 (10mg), TB-500 (10mg), GHK-Cu (50mg), and KPV (10mg) totaling 80mg per vial. Evolution of the Glow stack with added KPV for enhanced anti-inflammatory and gut health benefits.
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Educational Information Only
This information is provided for educational purposes only and is not intended as medical advice. Always consult with qualified healthcare providers before making any decisions about peptides or other substances. The protocols listed reflect doses observed in research studies, not recommendations.