A synthetic dipeptide (Glu-Trp) bioregulator derived from Thymalin, a thymus extract. One of Professor Khavinson's key immunomodulatory peptides, shown to stimulate T-lymphocyte development and normalize immune function. Has been used clinically in Russia for immune support.

Is Thymogen FDA approved?

No, Thymogen is not FDA approved. Current status: Approved in Russia - Clinical use for immunomodulation

What are the side effects of Thymogen?

Reported side effects of Thymogen include: Generally well-tolerated, No significant side effects reported in clinical use, Rare allergic reactions possible, Individual intolerance to components.

What is the typical dosing for Thymogen?

Khavinson bioregulator dosing - clinically used in Russia. Common doses observed in research: 10-20 mg daily (1-2 capsules), 100 mcg nasal spray (some regions). Duration: 30-day courses with 2-3 month breaks. Administration: Oral capsules, also available as nasal spray in some regions.

Immune

Thymogen

Also known as: EW Dipeptide, Glu-Trp, L-Glutamyl-L-Tryptophan, Oglufanide

Clinical Trials

Popular For

Immune modulation, T-cell support, immune aging

Key Facts: Thymogen

Category: Immune
FDA Status: Not FDA Approved
Clinical Status: Approved in Russia - Clinical use for immunomodulation
Administration: Oral capsules, also available as nasal spray in some regions
Typical Dose: 1-2 capsules (10-20 mg) daily
Frequency: 1-2x daily, before meals
Evidence Level: Human Trials
Duration: 30-day courses with 2-3 month breaks

Also Known As

EW Dipeptide, Glu-Trp, L-Glutamyl-L-Tryptophan, Oglufanide

Mechanism of Action

Thymogen (alpha-glutamyl-tryptophan) stimulates cellular factors of immunogenesis, promotes proliferation and differentiation of T-lymphocyte precursors into mature immunocompetent cells. It normalizes the ratio of T-helpers to T-suppressors, increases cyclic adenosine monophosphate (cAMP) in T-lymphocyte precursors, and modulates immune cell maturation. Pharmacokinetic studies show rapid tissue uptake, particularly in liver, adrenals, kidney, lymph nodes, and thymus.

Research Summary

Originally isolated from Thymalin via reversed-phase HPLC, then synthesized. Clinical studies in Russia show immunomodulatory effects including normalization of T-cell subsets. Animal studies demonstrate geroprotective activity - Thymogen administration in rats led to increased survival and 1.5-fold decrease in tumor development. Has been used clinically for over 20 years as an immunomodulator.

Clinical Status:Approved in Russia - Clinical use for immunomodulation

Trial Progress:Preclinical

Pre

III

FDA

Dosing Information

Human Trials·Clinical use in Russia, human studies conducted

Typical DosingⓘDoses commonly used by people in practice, based on community reports and anecdotal experience.

Community experience

Common Dose

1-2 capsules (10-20 mg) daily

Range

10-20 mg per day

Frequency

1-2x daily, before meals

Khavinson bioregulator with decades of clinical use in Russia. Often used in 30-day cycles with breaks between courses. May be combined with other thymus peptides like Vilon or Thymalin.

Research DosingⓘDoses from published scientific studies and clinical trials. May include human or animal research.

Scientific studies

Khavinson bioregulator dosing - clinically used in Russia

Doses from Studies

10-20 mg daily oral

Russian Clinical Practice - Over 20 years of clinical immunomodulation use ↗

100 mcg intranasal

Khavinson Research - Nasal spray formulation for immune support ↗

Duration

30-day courses with 2-3 month breaks

Administration

Oral capsules, also available as nasal spray in some regions

Timing & Administration

Best Time to Take

Morning, before meals

1-2 times daily

Food Recommendation

With or without food

Why This Timing?

Immune function peptides often taken morning to support daytime immune activity.

Possible Side Effects

Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.

●Generally well-tolerated
●No significant side effects reported in clinical use
●Rare allergic reactions possible
●Individual intolerance to components

References

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Educational Information Only

This information is provided for educational purposes only and is not intended as medical advice. Always consult with qualified healthcare providers before making any decisions about peptides or other substances. The protocols listed reflect doses observed in research studies, not recommendations.

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