Thymogen
Also known as: EW Dipeptide, Glu-Trp, L-Glutamyl-L-Tryptophan, Oglufanide
Key Facts: Thymogen
- Category
- Immune
- FDA Status
- Not FDA Approved
- Clinical Status
- Approved in Russia - Clinical use for immunomodulation
- Administration
- Oral capsules, also available as nasal spray in some regions
- Typical Dose
- 1-2 capsules (10-20 mg) daily
- Frequency
- 1-2x daily, before meals
- Duration
- 30-day courses with 2-3 month breaks
Mechanism of Action
Thymogen (alpha-glutamyl-tryptophan) stimulates cellular factors of immunogenesis, promotes proliferation and differentiation of T-lymphocyte precursors into mature immunocompetent cells. It normalizes the ratio of T-helpers to T-suppressors, increases cyclic adenosine monophosphate (cAMP) in T-lymphocyte precursors, and modulates immune cell maturation. Pharmacokinetic studies show rapid tissue uptake, particularly in liver, adrenals, kidney, lymph nodes, and thymus.
Research Summary
Originally isolated from Thymalin via reversed-phase HPLC, then synthesized. Clinical studies in Russia show immunomodulatory effects including normalization of T-cell subsets. Animal studies demonstrate geroprotective activity - Thymogen administration in rats led to increased survival and 1.5-fold decrease in tumor development. Has been used clinically for over 20 years as an immunomodulator.
Dosing Information
Typical Dosingⓘ
Community experience
1-2 capsules (10-20 mg) daily
10-20 mg per day
1-2x daily, before meals
Khavinson bioregulator with decades of clinical use in Russia. Often used in 30-day cycles with breaks between courses. May be combined with other thymus peptides like Vilon or Thymalin.
Research Dosingⓘ
Scientific studies
Khavinson bioregulator dosing - clinically used in Russia
Doses from Studies
10-20 mg daily oral
Russian Clinical Practice - Over 20 years of clinical immunomodulation use ↗
100 mcg intranasal
Khavinson Research - Nasal spray formulation for immune support ↗
Duration
30-day courses with 2-3 month breaks
Administration
Oral capsules, also available as nasal spray in some regions
Timing & Administration
Best Time to Take
Morning, before meals
1-2 times daily
Food Recommendation
With or without food
Why This Timing?
Immune function peptides often taken morning to support daytime immune activity.
Possible Side Effects
Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.
- ●Generally well-tolerated
- ●No significant side effects reported in clinical use
- ●Rare allergic reactions possible
- ●Individual intolerance to components
References
- https://pubmed.ncbi.nlm.nih.gov/14523363/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC8365293/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC8999041/
Research This Peptide Further
Frequently Asked Questions
What does Thymogen do?
A synthetic dipeptide (Glu-Trp) bioregulator derived from Thymalin, a thymus extract. One of Professor Khavinson's key immunomodulatory peptides, shown to stimulate T-lymphocyte development and normalize immune function. Has been used clinically in Russia for immune support.
How does Thymogen work?
Thymogen (alpha-glutamyl-tryptophan) stimulates cellular factors of immunogenesis, promotes proliferation and differentiation of T-lymphocyte precursors into mature immunocompetent cells. It normalizes the ratio of T-helpers to T-suppressors, increases cyclic adenosine monophosphate (cAMP) in T-lymphocyte precursors, and modulates immune cell maturation. Pharmacokinetic studies show rapid tissue uptake, particularly in liver, adrenals, kidney, lymph nodes, and thymus.
Is Thymogen FDA approved?
No, Thymogen is not currently FDA approved. Current status: Approved in Russia - Clinical use for immunomodulation
What are the side effects of Thymogen?
Reported side effects include: Generally well-tolerated, No significant side effects reported in clinical use, Rare allergic reactions possible, Individual intolerance to components. Individual responses vary based on dosage, duration, and personal health factors.
What is the typical dose of Thymogen?
Community-reported common dose: 1-2 capsules (10-20 mg) daily (1-2x daily, before meals). Range: 10-20 mg per day. Administration: Oral capsules, also available as nasal spray in some regions. Community-reported doses. Not FDA approved. Consult healthcare provider.
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