How to Use LL-37
Complete guide to LL-37 dosing, administration, timing, and protocol recommendations.
Quick Overview
LL-37 is the only cathelicidin antimicrobial peptide humans make, a 37-amino-acid, positively charged, helical fragment cut from a precursor protein called hCAP-18. It is a frontline player in the innate immune system, part of the body's chemical defense against bacteria, viruses, and fungi. This is mainstream, heavily studied human biology, not a fringe research peptide, though LL-37 itself is not an approved drug.
Dosing Guidelines
Common Dose
100-200 mcg daily
Frequency
Once daily
Dose Range
50-300 mcg daily
Note: Antimicrobial peptide. Used for infections, biofilm disruption. Some use higher doses for acute infections.
Administration Method
Subcutaneous injection or topical
Best Time to Take
Morning
LL-37 is an antimicrobial peptide. Morning use supports daytime immune surveillance.
Protocol Duration
Variable by protocol
Possible Side Effects
Not everyone experiences these. Individual responses vary.
- •Injection site reactions (common)
- •Skin toxicity (ulcers, burning)
- •Allergic reactions
- •May trigger histamine release - use caution with MCAS or histamine sensitivity
- •May contribute to autoimmune conditions
Frequently Asked Questions
What is the recommended dose for LL-37?
100-200 mcg daily
How do you administer LL-37?
Subcutaneous injection or topical
When is the best time to take LL-37?
Morning
How long should you use LL-37?
Variable by protocol
This information is for educational purposes only. Always consult with a healthcare professional before using any peptide. Dosing information is based on research literature and community reports, not medical advice.