A tetrapeptide bioregulator (Ala-Glu-Asp-Pro) derived from cerebral cortex extracts. Studied for neuroprotection, neural differentiation, and cognitive support. Regulates neurotrophic signaling and synaptic stability.

Is Cortagen FDA approved?

No, Cortagen is not FDA approved. Current status: Preclinical research, approved in Russia as supplement

What are the side effects of Cortagen?

Reported side effects of Cortagen include: Generally well-tolerated, Limited safety data outside Russia, Not FDA approved.

What is the typical dosing for Cortagen?

Doses from bioregulator supplement protocols. Common doses observed in research: 10-20 mg daily. Duration: 10-30 day cycles. Administration: Oral capsules or sublingual.

Bioregulators

Cortagen

Also known as: Ala-Glu-Asp-Pro, AEDP

Preclinical

Popular For

Brain function, cognitive support, neuroprotection

Key Facts: Cortagen

Category: Bioregulators
FDA Status: Not FDA Approved
Clinical Status: Preclinical research, approved in Russia as supplement
Administration: Oral capsules or sublingual
Typical Dose: 10-20 mg daily
Frequency: Once or twice daily
Evidence Level: Preclinical
Duration: 10-30 day cycles

Also Known As

Ala-Glu-Asp-Pro, AEDP

Mechanism of Action

Cortagen regulates neurotrophic signaling, gene transcription, and peptide-mediated synaptic stability in brain tissue. It activates interleukin-2 mRNA synthesis and has been studied as a corrector of functional and metabolic disorders in the brain under chronic ischemia conditions.

Research Summary

Research shows Cortagen activates IL-2 mRNA synthesis in vitro. Studies examined its role in correcting brain metabolic disorders under chronic ischemia. Part of Khavinson's synthesized peptide series with demonstrated effects on ribosome genes and chromatin in elderly subjects.

Clinical Status:Preclinical research, approved in Russia as supplement

Trial Progress:Preclinical

Pre

III

FDA

Dosing Information

Preclinical·Animal and cell studies, limited human data

Note: Animal study doses may not translate directly to humans.

Typical DosingⓘDoses commonly used by people in practice, based on community reports and anecdotal experience.

Community experience

Common Dose

10-20 mg daily

Range

10-20 mg daily

Frequency

Once or twice daily

Brain/CNS bioregulator from Khavinson research. Run in cycles.

Research DosingⓘDoses from published scientific studies and clinical trials. May include human or animal research.

Scientific studies

Doses from bioregulator supplement protocols

Doses from Studies

10-20 mg daily

Duration

10-30 day cycles

Administration

Oral capsules or sublingual

Timing & Administration

Best Time to Take

Morning on empty stomach

Once or twice daily

Food Recommendation

Take on empty stomach

Why This Timing?

Peptide bioregulators typically taken fasted for optimal absorption

Possible Side Effects

Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.

●Generally well-tolerated
●Limited safety data outside Russia
●Not FDA approved

References

https://www.peptidesciences.com/cortagen-20mg-bioregulator

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