Cortagen
Also known as: Ala-Glu-Asp-Pro, AEDP
Key Facts: Cortagen
- Category
- Bioregulators
- FDA Status
- Not FDA Approved
- Clinical Status
- Preclinical research, approved in Russia as supplement
- Administration
- Oral capsules or sublingual
- Typical Dose
- 10-20 mg daily
- Frequency
- Once or twice daily
- Evidence Level
- Preclinical
- Duration
- 10-30 day cycles
What to Expect
A tetrapeptide bioregulator (Ala-Glu-Asp-Pro) derived from cerebral cortex extracts. Studied for neuroprotection, neural differentiation, and cognitive support. Regulates neurotrophic signaling and synaptic stability.
Mechanism of Action
Cortagen regulates neurotrophic signaling, gene transcription, and peptide-mediated synaptic stability in brain tissue. It activates interleukin-2 mRNA synthesis and has been studied as a corrector of functional and metabolic disorders in the brain under chronic ischemia conditions.
Research Summary
Research shows Cortagen activates IL-2 mRNA synthesis in vitro. Studies examined its role in correcting brain metabolic disorders under chronic ischemia. Part of Khavinson's synthesized peptide series with demonstrated effects on ribosome genes and chromatin in elderly subjects.
Dosing Information
Typical Dosingⓘ
Community experience
10-20 mg daily
10-20 mg daily
Once or twice daily
Brain/CNS bioregulator from Khavinson research. Run in cycles.
Research Dosingⓘ
Scientific studies
Doses from bioregulator supplement protocols
Doses from Studies
10-20 mg daily
Duration
10-30 day cycles
Administration
Oral capsules or sublingual
Timing & Administration
Best Time to Take
Morning on empty stomach
Once or twice daily
Food Recommendation
Take on empty stomach
Why This Timing?
Peptide bioregulators typically taken fasted for optimal absorption
Possible Side Effects
Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.
- ●Generally well-tolerated
- ●Limited safety data outside Russia
- ●Not FDA approved
References
Related Peptides
Peptides commonly compared with Cortagen or used in similar applications.
Pinealon
PreclinicalA synthetic tripeptide bioregulator targeting brain tissue. Part of Khavinson's peptide research, designed to support cognitive function and neuroprotection.
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PreclinicalA tetrapeptide bioregulator (Lys-Glu-Asp-Ala) developed by Khavinson that modulates chromatin structure and gene expression. Research shows it can decondense heterochromatin and activate ribosomal genes, potentially restoring more youthful gene expression patterns in aging cells.
BioregulatorsOvagen
PreclinicalA tripeptide bioregulator (Glu-Asp-Leu) targeting liver and gastrointestinal tissue. Derived from liver tissue extracts, Ovagen modulates gene expression related to detoxification, antioxidant defense, and hepatocellular repair.
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PreclinicalA tripeptide bioregulator (Lys-Glu-Asp) targeting vascular tissue. Promotes restoration of blood vessel tissues and normalization of vascular function. Stimulates endothelial cell proliferation markers.
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PreclinicalA tripeptide bioregulator targeting respiratory and lung tissue. Supports healthy lung function and stomach lining. Regulates inflammatory and proliferative processes in respiratory epithelium.
BioregulatorsCrystagen
PreclinicalA tripeptide bioregulator supporting immune system function. Demonstrates age-associated immunoprotective properties in spleen tissue. Part of the Khavinson synthesized peptide series.
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Educational Information Only
This information is provided for educational purposes only and is not intended as medical advice. Always consult with qualified healthcare providers before making any decisions about peptides or other substances. The protocols listed reflect doses observed in research studies, not recommendations.