MOTS-c vs Humanin
Comprehensive side-by-side comparison of mechanisms, dosing, side effects, and research
Also: Mitochondrial ORF of the 12S rRNA type-c
A mitochondria-derived peptide that regulates metabolic homeostasis. Discovered in 2015, it's being studied for its effects on insulin sensitivity, exercise capacity, and aging.
Also: HN, HNG (S14G-humanin)
A mitochondria-derived peptide discovered for its neuroprotective effects against Alzheimer's-related toxicity. Being studied for aging and metabolic benefits.
Key Comparison Insights
- MOTS-c is categorized as Hormonal, while Humanin is Anti-Aging.
Detailed Comparison
| Attribute | MOTS-c | Humanin |
|---|---|---|
| Category | Hormonal | Anti-Aging |
| FDA Status | Not FDA Approved | Not FDA Approved |
| Clinical Status | Pre I II III IV FDA | Pre I II III IV FDA |
| Mechanism of Action | MOTS-c is encoded by mitochondrial DNA and acts as a mitokine, communicating mitochondrial status to the rest of the body. It activates AMPK, improves glucose uptake, enhances fatty acid oxidation, and has systemic metabolic regulatory effects. | Humanin acts through multiple pathways including STAT3 signaling, binding to IGFBP-3, and activating the FPRL1 receptor. It protects neurons from apoptosis, improves insulin sensitivity, and has anti-inflammatory effects. |
| Common Dosing | 5-10 mg weekly 1-3x weekly | 5-10 mg weekly divided into 2-3 injections 2-3x weekly (e.g., Monday, Wednesday, Friday) |
| Administration | Subcutaneous injection | Injection (route varies) |
| Typical Duration | Variable by protocol | Variable |
| Best Time to Take | Morning or pre-workout | Morning |
Possible Side Effects May vary by individual |
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| Research Summary | Studies show MOTS-c improves insulin sensitivity and prevents diet-induced obesity in mice. Research demonstrates enhanced exercise capacity and protection against age-related metabolic decline. Human studies are limited but promising. | Research shows protection against amyloid-beta toxicity in Alzheimer's models. Studies demonstrate improved insulin sensitivity, reduced atherosclerosis in animal models, and potential anti-aging effects. Human studies are limited. |
Frequently Asked Questions: MOTS-c vs Humanin
What is the difference between MOTS-c and Humanin?
MOTS-c is a hormonal peptide that a mitochondria-derived peptide that regulates metabolic homeostasis. discovered in 2015, it's being studied for its effects on insulin sensitivity, exercise capacity, and aging. Humanin is a anti-aging peptide that a mitochondria-derived peptide discovered for its neuroprotective effects against alzheimer's-related toxicity. being studied for aging and metabolic benefits. The main differences lie in their mechanisms of action and clinical applications.
Which is better, MOTS-c or Humanin?
Neither is universally "better" - the choice depends on your specific goals. MOTS-c is typically used for hormonal purposes, while Humanin is used for anti-aging. Always consult with a healthcare provider to determine which may be appropriate for your situation.
Can MOTS-c and Humanin be used together?
Some peptide protocols combine multiple compounds for synergistic effects. However, using MOTS-c and Humanin together should only be considered under medical supervision, as both compounds have their own side effect profiles and potential interactions. Research on their combined use may be limited.
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Educational Information Only
This comparison of MOTS-c and Humanin is for educational purposes only. Neither this comparison nor any information on this site constitutes medical advice. Always consult with qualified healthcare providers before making decisions about peptides or other substances.