Epithalon vs MOTS-c
Comprehensive side-by-side comparison of mechanisms, dosing, side effects, and research
Also: Epitalon, Epithalone
A tetrapeptide studied for its effects on telomerase activation and potential anti-aging properties. Based on research by Professor Vladimir Khavinson.
Also: Mitochondrial ORF of the 12S rRNA type-c
A mitochondria-derived peptide that regulates metabolic homeostasis. Discovered in 2015, it's being studied for its effects on insulin sensitivity, exercise capacity, and aging.
Key Comparison Insights
- Epithalon is categorized as Bioregulators, while MOTS-c is Hormonal.
- Epithalon has stronger research evidence (Human Trials) compared to MOTS-c (Animal Studies).
Detailed Comparison
| Attribute | Epithalon | MOTS-c |
|---|---|---|
| Category | Bioregulators | Hormonal |
| FDA Status | Not FDA Approved | Not FDA Approved |
| Clinical Status | Pre I II III IV FDA | Pre I II III IV FDA |
| Mechanism of Action | Epithalon stimulates telomerase production, potentially slowing or reversing telomere shortening. It may also regulate melatonin production by the pineal gland and has been shown to influence gene expression related to aging. | MOTS-c is encoded by mitochondrial DNA and acts as a mitokine, communicating mitochondrial status to the rest of the body. It activates AMPK, improves glucose uptake, enhances fatty acid oxidation, and has systemic metabolic regulatory effects. |
| Common Dosing | 5-10 mg daily for 10-20 days Once daily in cycles | 5-10 mg weekly 1-3x weekly |
| Administration | Subcutaneous or intramuscular injection | Subcutaneous injection |
| Typical Duration | 10-20 day cycles | Variable by protocol |
| Best Time to Take | Before bed | Morning or pre-workout |
Possible Side Effects May vary by individual |
|
|
| Research Summary | Russian studies show increased telomerase activity and extended lifespan in animal models. Human studies suggest improved sleep, reduced cortisol, and potential immune benefits. Research quality and Western replication remains limited. | Studies show MOTS-c improves insulin sensitivity and prevents diet-induced obesity in mice. Research demonstrates enhanced exercise capacity and protection against age-related metabolic decline. Human studies are limited but promising. |
Frequently Asked Questions: Epithalon vs MOTS-c
What is the difference between Epithalon and MOTS-c?
Epithalon is a bioregulators peptide that a tetrapeptide studied for its effects on telomerase activation and potential anti-aging properties. based on research by professor vladimir khavinson. MOTS-c is a hormonal peptide that a mitochondria-derived peptide that regulates metabolic homeostasis. discovered in 2015, it's being studied for its effects on insulin sensitivity, exercise capacity, and aging. The main differences lie in their mechanisms of action and clinical applications.
Which is better, Epithalon or MOTS-c?
Neither is universally "better" - the choice depends on your specific goals. Epithalon is typically used for bioregulators purposes, while MOTS-c is used for hormonal. Always consult with a healthcare provider to determine which may be appropriate for your situation.
Can Epithalon and MOTS-c be used together?
Some peptide protocols combine multiple compounds for synergistic effects. However, using Epithalon and MOTS-c together should only be considered under medical supervision, as both compounds have their own side effect profiles and potential interactions. Research on their combined use may be limited.
Related Comparisons
View Full Peptide Profiles
Educational Information Only
This comparison of Epithalon and MOTS-c is for educational purposes only. Neither this comparison nor any information on this site constitutes medical advice. Always consult with qualified healthcare providers before making decisions about peptides or other substances.