Selank vs GB-115
Comprehensive side-by-side comparison of mechanisms, dosing, side effects, and research
Also: Selanc, TP-7
A synthetic peptide derived from tuftsin, an immunomodulatory peptide. Approved in Russia for anxiety and nootropic effects. Known for anxiolytic properties without sedation.
Also: Ranquilon, N-phenylacetyl-L-prolylglycine ethyl ester
A dipeptide anxiolytic and nootropic that acts as a CCK-1 (cholecystokinin) receptor antagonist. Developed in Russia with completed Phase 3 trials for anxiety. Users report significant improvements in focus, attention, and ADHD-like symptoms.
Key Comparison Insights
- Both peptides belong to the Cognitive category, suggesting similar primary applications.
Detailed Comparison
| Attribute | Selank | GB-115 |
|---|---|---|
| Category | Cognitive | Cognitive |
| FDA Status | Not FDA Approved | Not FDA Approved |
| Clinical Status | Pre I II III IV FDA | Pre I II III IV FDA |
| Mechanism of Action | Selank modulates the expression of BDNF (brain-derived neurotrophic factor), influences serotonin and dopamine metabolism, and has effects on the GABAergic system. It also has immunomodulatory properties inherited from its tuftsin backbone. | GB-115 works by blocking central cholecystokinin-1 (CCK-1) receptors in the brain. CCK is involved in anxiety, panic responses, and cognitive modulation. By antagonizing these receptors, GB-115 reduces anxiety while improving attention, processing speed, and reaction time. It also modulates dopaminergic pathways involved in focus and motivation. |
| Common Dosing | 250-500 mcg intranasal 2-3x daily 2-3x daily, intranasal | 6 mg daily (2 mg three times daily) 2-3 times daily (morning, afternoon, evening) |
| Administration | Intranasal spray (most common), subcutaneous injection | Oral tablets or sublingual |
| Typical Duration | 14-21 days typical | 21+ days in clinical trials, effects noted by day 7 |
| Best Time to Take | Morning or as needed for anxiety | Morning and throughout the day |
Possible Side Effects May vary by individual |
|
|
| Research Summary | Russian clinical trials demonstrate anxiolytic effects comparable to benzodiazepines without sedation or addiction potential. Studies show improved cognitive function under stress, enhanced memory, and stabilization of mood. Note: Selank was removed from FDA Category 2 in September 2024 when nominators withdrew the substance - now scheduled for PCAC review. | Clinical studies in patients with Generalized Anxiety Disorder (GAD) showed GB-115 (6mg/day) significantly improved reaction time, attention, and processing speed within 7 days of treatment. A 21-day trial with 31 patients demonstrated anxiolytic effects comparable to benzodiazepines without sedation or dependency. Currently in Phase II/III trials (NCT05586789) for anxiety disorders. Anecdotal reports suggest benefits for ADHD symptoms, though direct ADHD trials are pending. |
Frequently Asked Questions: Selank vs GB-115
What is the difference between Selank and GB-115?
Selank is a cognitive peptide that a synthetic peptide derived from tuftsin, an immunomodulatory peptide. approved in russia for anxiety and nootropic effects. known for anxiolytic properties without sedation. GB-115 is a cognitive peptide that a dipeptide anxiolytic and nootropic that acts as a cck-1 (cholecystokinin) receptor antagonist. developed in russia with completed phase 3 trials for anxiety. users report significant improvements in focus, attention, and adhd-like symptoms. The main differences lie in their mechanisms of action and clinical applications.
Which is better, Selank or GB-115?
Neither is universally "better" - the choice depends on your specific goals. Selank is typically used for cognitive purposes, while GB-115 is used for cognitive. Always consult with a healthcare provider to determine which may be appropriate for your situation.
Can Selank and GB-115 be used together?
Some peptide protocols combine multiple compounds for synergistic effects. However, using Selank and GB-115 together should only be considered under medical supervision, as both compounds have their own side effect profiles and potential interactions. Research on their combined use may be limited.