Selank vs GB-115
Comprehensive side-by-side comparison of mechanisms, dosing, side effects, and research
Also: Selanc, TP-7
A synthetic peptide derived from tuftsin, an immunomodulatory peptide. Approved in Russia for anxiety and nootropic effects. Known for anxiolytic properties without sedation.
Also: Ranquilon, N-phenylacetyl-L-prolylglycine ethyl ester
A dipeptide anxiolytic and nootropic that acts as a CCK-1 (cholecystokinin) receptor antagonist. Developed in Russia with completed Phase 3 trials for anxiety. Users report significant improvements in focus, attention, and ADHD-like symptoms.
Key Comparison Insights
- Both peptides belong to the Cognitive category, suggesting similar primary applications.
Detailed Comparison
| Attribute | Selank | GB-115 |
|---|---|---|
| Category | Cognitive | Cognitive |
| FDA Status | Not FDA Approved | Not FDA Approved |
| Clinical Status | Pre I II III IV FDA | Pre I II III IV FDA |
| Mechanism of Action | Selank modulates the expression of BDNF (brain-derived neurotrophic factor), influences serotonin and dopamine metabolism, and has effects on the GABAergic system. It also has immunomodulatory properties inherited from its tuftsin backbone. | GB-115 works by blocking central cholecystokinin-1 (CCK-1) receptors in the brain. CCK is involved in anxiety, panic responses, and cognitive modulation. By antagonizing these receptors, GB-115 reduces anxiety while improving attention, processing speed, and reaction time. It also modulates dopaminergic pathways involved in focus and motivation. |
| Common Dosing | 250-500 mcg intranasal 2-3x daily 2-3x daily, intranasal | 6 mg daily (2 mg three times daily) 2-3 times daily (morning, afternoon, evening) |
| Administration | Intranasal spray (most common), subcutaneous injection | Oral tablets or sublingual |
| Typical Duration | 14-21 days typical | 21+ days in clinical trials, effects noted by day 7 |
| Best Time to Take | Morning or as needed for anxiety | Morning and throughout the day |
Possible Side Effects May vary by individual |
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| Research Summary | Russian clinical trials demonstrate anxiolytic effects comparable to benzodiazepines without sedation or addiction potential. Studies show improved cognitive function under stress, enhanced memory, and stabilization of mood. | Clinical studies in patients with Generalized Anxiety Disorder (GAD) showed GB-115 (6mg/day) significantly improved reaction time, attention, and processing speed within 7 days of treatment. A 21-day trial with 31 patients demonstrated anxiolytic effects comparable to benzodiazepines without sedation or dependency. Currently in Phase II/III trials (NCT05586789) for anxiety disorders. Anecdotal reports suggest benefits for ADHD symptoms, though direct ADHD trials are pending. |
Frequently Asked Questions: Selank vs GB-115
What is the difference between Selank and GB-115?
Selank is a cognitive peptide that a synthetic peptide derived from tuftsin, an immunomodulatory peptide. approved in russia for anxiety and nootropic effects. known for anxiolytic properties without sedation. GB-115 is a cognitive peptide that a dipeptide anxiolytic and nootropic that acts as a cck-1 (cholecystokinin) receptor antagonist. developed in russia with completed phase 3 trials for anxiety. users report significant improvements in focus, attention, and adhd-like symptoms. The main differences lie in their mechanisms of action and clinical applications.
Which is better, Selank or GB-115?
Neither is universally "better" - the choice depends on your specific goals. Selank is typically used for cognitive purposes, while GB-115 is used for cognitive. Always consult with a healthcare provider to determine which may be appropriate for your situation.
Can Selank and GB-115 be used together?
Some peptide protocols combine multiple compounds for synergistic effects. However, using Selank and GB-115 together should only be considered under medical supervision, as both compounds have their own side effect profiles and potential interactions. Research on their combined use may be limited.
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Educational Information Only
This comparison of Selank and GB-115 is for educational purposes only. Neither this comparison nor any information on this site constitutes medical advice. Always consult with qualified healthcare providers before making decisions about peptides or other substances.