GHRP-6 vs Hexarelin
Comprehensive side-by-side comparison of mechanisms, dosing, side effects, and research
Also: Growth Hormone Releasing Peptide 6, SKF-110679
One of the first synthetic GH secretagogues developed. Strongly stimulates GH release and significantly increases appetite through ghrelin receptor activation.
Also: Examorelin, HEX
A synthetic hexapeptide GH secretagogue with the strongest GH-releasing effect among GHRPs. Also has notable cardioprotective properties independent of GH release.
Key Comparison Insights
- Both peptides belong to the Growth Hormone category, suggesting similar primary applications.
Detailed Comparison
| Attribute | GHRP-6 | Hexarelin |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| FDA Status | Not FDA Approved | Not FDA Approved |
| Clinical Status | Pre I II III IV FDA | Pre I II III IV FDA |
| Mechanism of Action | GHRP-6 binds to ghrelin receptors (GHSR-1a) in the hypothalamus and pituitary, triggering a strong GH release. It also activates the hunger-signaling pathway, leading to significant appetite increase. Stimulates cortisol and prolactin more than newer GHRPs. | Hexarelin activates ghrelin receptors (GHSR-1a) causing potent GH release. Uniquely, it also binds to CD36 receptors in cardiac tissue, providing cardioprotective effects independent of GH. Causes significant cortisol and prolactin elevation. |
| Common Dosing | 100-300 mcg 2-3x daily 2-3x daily | 100-200 mcg 2-3x daily 2-3x daily |
| Administration | Subcutaneous injection, ideally fasted | Subcutaneous injection |
| Typical Duration | 8-12 weeks | 4-8 weeks (desensitization occurs) |
| Best Time to Take | Before bed or morning (fasted) | Morning and before bed (fasted) |
Possible Side Effects May vary by individual |
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| Research Summary | Well-studied peptide showing reliable GH release. Research demonstrates cardioprotective effects in animal models, improved wound healing, and significant appetite stimulation. Studies show 3-6 fold increase in GH levels. | Studies show the highest GH release among GHRPs but with desensitization over time. Cardiac research demonstrates protection against ischemia and improved heart function. Used in GH deficiency diagnosis due to reliable GH stimulation. |
Frequently Asked Questions: GHRP-6 vs Hexarelin
What is the difference between GHRP-6 and Hexarelin?
GHRP-6 is a growth hormone peptide that one of the first synthetic gh secretagogues developed. strongly stimulates gh release and significantly increases appetite through ghrelin receptor activation. Hexarelin is a growth hormone peptide that a synthetic hexapeptide gh secretagogue with the strongest gh-releasing effect among ghrps. also has notable cardioprotective properties independent of gh release. The main differences lie in their mechanisms of action and clinical applications.
Which is better, GHRP-6 or Hexarelin?
Neither is universally "better" - the choice depends on your specific goals. GHRP-6 is typically used for growth hormone purposes, while Hexarelin is used for growth hormone. Always consult with a healthcare provider to determine which may be appropriate for your situation.
Can GHRP-6 and Hexarelin be used together?
Some peptide protocols combine multiple compounds for synergistic effects. However, using GHRP-6 and Hexarelin together should only be considered under medical supervision, as both compounds have their own side effect profiles and potential interactions. Research on their combined use may be limited.
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Educational Information Only
This comparison of GHRP-6 and Hexarelin is for educational purposes only. Neither this comparison nor any information on this site constitutes medical advice. Always consult with qualified healthcare providers before making decisions about peptides or other substances.