CJC-1295 vs GHRP-6
Comprehensive side-by-side comparison of mechanisms, dosing, side effects, and research
Also: CJC-1295 DAC, CJC-1295 no DAC
A synthetic analog of growth hormone-releasing hormone (GHRH) that stimulates GH release from the pituitary. Often combined with a GHRP like Ipamorelin for synergistic effects.
Also: Growth Hormone Releasing Peptide 6, SKF-110679
One of the first synthetic GH secretagogues developed. Strongly stimulates GH release and significantly increases appetite through ghrelin receptor activation.
Key Comparison Insights
- Both peptides belong to the Growth Hormone category, suggesting similar primary applications.
- These GH secretagogues are frequently combined to enhance growth hormone release.
Detailed Comparison
| Attribute | CJC-1295 | GHRP-6 |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| FDA Status | Not FDA Approved | Not FDA Approved |
| Clinical Status | Pre I II III IV FDA | Pre I II III IV FDA |
| Mechanism of Action | CJC-1295 binds to GHRH receptors on the pituitary, stimulating GH synthesis and release. The DAC (Drug Affinity Complex) version binds to albumin, extending half-life to 6-8 days. Without DAC (Mod GRF 1-29), half-life is about 30 minutes. | GHRP-6 binds to ghrelin receptors (GHSR-1a) in the hypothalamus and pituitary, triggering a strong GH release. It also activates the hunger-signaling pathway, leading to significant appetite increase. Stimulates cortisol and prolactin more than newer GHRPs. |
| Common Dosing | 100 mcg daily (no DAC) or 2 mg weekly (with DAC) Daily (no DAC) or 1-2x weekly (with DAC) | 100-300 mcg 2-3x daily 2-3x daily |
| Administration | Subcutaneous injection | Subcutaneous injection, ideally fasted |
| Typical Duration | 8-12 weeks | 8-12 weeks |
| Best Time to Take | Before bed | Before bed or morning (fasted) |
Possible Side Effects May vary by individual |
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| Research Summary | Studies show sustained elevation of GH and IGF-1 levels. Research demonstrates 2-10 fold increase in GH levels depending on dose and formulation. Combination with GHRP produces synergistic GH release greater than either alone. | Well-studied peptide showing reliable GH release. Research demonstrates cardioprotective effects in animal models, improved wound healing, and significant appetite stimulation. Studies show 3-6 fold increase in GH levels. |
Frequently Asked Questions: CJC-1295 vs GHRP-6
What is the difference between CJC-1295 and GHRP-6?
CJC-1295 is a growth hormone peptide that a synthetic analog of growth hormone-releasing hormone (ghrh) that stimulates gh release from the pituitary. often combined with a ghrp like ipamorelin for synergistic effects. GHRP-6 is a growth hormone peptide that one of the first synthetic gh secretagogues developed. strongly stimulates gh release and significantly increases appetite through ghrelin receptor activation. The main differences lie in their mechanisms of action and clinical applications.
Which is better, CJC-1295 or GHRP-6?
Neither is universally "better" - the choice depends on your specific goals. CJC-1295 is typically used for growth hormone purposes, while GHRP-6 is used for growth hormone. Always consult with a healthcare provider to determine which may be appropriate for your situation.
Can CJC-1295 and GHRP-6 be used together?
Some peptide protocols combine multiple compounds for synergistic effects. However, using CJC-1295 and GHRP-6 together should only be considered under medical supervision, as both compounds have their own side effect profiles and potential interactions. Research on their combined use may be limited.
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Educational Information Only
This comparison of CJC-1295 and GHRP-6 is for educational purposes only. Neither this comparison nor any information on this site constitutes medical advice. Always consult with qualified healthcare providers before making decisions about peptides or other substances.