TB-500 vs GHK-Cu
Comprehensive side-by-side comparison of mechanisms, dosing, side effects, and research
A synthetic 17-amino acid fragment of Thymosin Beta-4 (TB-4). NOT the same as TB-4 - TB-500 has a longer half-life (~2-4 days vs ~2 hours) and is the active region responsible for tissue repair and cell migration. Note: Many vendors mislabel TB-4 as 'TB-500' in premixed products.
Also: Copper Peptide, Glycyl-L-histidyl-L-lysine copper
A naturally occurring copper-binding peptide found in human plasma, saliva, and urine. Widely used in skincare for its wound healing and anti-aging properties.
Key Comparison Insights
- TB-500 is categorized as Healing, while GHK-Cu is Skin & Hair.
- TB-500 has stronger research evidence (Human Trials) compared to GHK-Cu (Limited Research).
- These peptides are often used together in healing protocols for synergistic effects.
Detailed Comparison
| Attribute | TB-500 | GHK-Cu |
|---|---|---|
| Category | Healing | Skin & Hair |
| FDA Status | Not FDA Approved | Not FDA Approved |
| Clinical Status | Pre I II III IV FDA | Pre I II III IV FDA |
| Mechanism of Action | TB-500 is derived from the active region of the full Thymosin Beta-4 protein. It promotes cell migration by binding to and sequestering actin, a protein essential for cell movement. It upregulates actin expression, promotes angiogenesis, reduces inflammation, and facilitates hair follicle stem cell migration for wound healing. | GHK-Cu stimulates collagen and elastin synthesis, promotes glycosaminoglycan production, supports blood vessel growth, and has antioxidant and anti-inflammatory properties. It remodels damaged tissue and activates wound-healing genes. |
| Common Dosing | 2-2.5 mg twice weekly (loading), then 2.5 mg once weekly (maintenance) 2x weekly for 4-6 weeks, then 1x weekly | 1-2 mg daily (injection) or topical Once daily |
| Administration | Subcutaneous or intramuscular injection | Subcutaneous injection or topical application |
| Typical Duration | 4-6 weeks loading, then maintenance | Varies by application |
| Best Time to Take | Morning or evening | Evening (for skin/recovery) |
Possible Side Effects May vary by individual |
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| Research Summary | Research shows significant wound healing acceleration, cardiac tissue repair after heart attack in animal models, and anti-inflammatory effects. Studies demonstrate improved recovery from dermal wounds and muscle injuries. Human clinical trials ongoing for wound healing applications. | Studies demonstrate increased collagen synthesis, improved skin elasticity, reduced fine lines, and accelerated wound healing. Research shows it can reset gene expression to a healthier state and may have systemic anti-aging effects beyond skin. |
Frequently Asked Questions: TB-500 vs GHK-Cu
What is the difference between TB-500 and GHK-Cu?
TB-500 is a healing peptide that a synthetic 17-amino acid fragment of thymosin beta-4 (tb-4). not the same as tb-4 - tb-500 has a longer half-life (~2-4 days vs ~2 hours) and is the active region responsible for tissue repair and cell migration. note: many vendors mislabel tb-4 as 'tb-500' in premixed products. GHK-Cu is a skin & hair peptide that a naturally occurring copper-binding peptide found in human plasma, saliva, and urine. widely used in skincare for its wound healing and anti-aging properties. The main differences lie in their mechanisms of action and clinical applications.
Which is better, TB-500 or GHK-Cu?
Neither is universally "better" - the choice depends on your specific goals. TB-500 is typically used for healing purposes, while GHK-Cu is used for skin & hair. Always consult with a healthcare provider to determine which may be appropriate for your situation.
Can TB-500 and GHK-Cu be used together?
Some peptide protocols combine multiple compounds for synergistic effects. However, using TB-500 and GHK-Cu together should only be considered under medical supervision, as both compounds have their own side effect profiles and potential interactions. Research on their combined use may be limited.
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Educational Information Only
This comparison of TB-500 and GHK-Cu is for educational purposes only. Neither this comparison nor any information on this site constitutes medical advice. Always consult with qualified healthcare providers before making decisions about peptides or other substances.