BPC-157 vs TB-500
Comprehensive side-by-side comparison of mechanisms, dosing, side effects, and research
Also: Body Protection Compound-157, Pentadecapeptide BPC 157
A synthetic peptide derived from a protein found in human gastric juice. Known for its remarkable tissue healing properties across multiple body systems.
A synthetic 17-amino acid fragment of Thymosin Beta-4 (TB-4). NOT the same as TB-4 - TB-500 has a longer half-life (~2-4 days vs ~2 hours) and is the active region responsible for tissue repair and cell migration. Note: Many vendors mislabel TB-4 as 'TB-500' in premixed products.
Key Comparison Insights
- Both peptides belong to the Healing category, suggesting similar primary applications.
- TB-500 has stronger research evidence (Human Trials) compared to BPC-157 (Animal Studies).
- These peptides are often used together in healing protocols for synergistic effects.
Detailed Comparison
| Attribute | BPC-157 | TB-500 |
|---|---|---|
| Category | Healing | Healing |
| FDA Status | Not FDA Approved | Not FDA Approved |
| Clinical Status | Pre I II III IV FDA | Pre I II III IV FDA |
| Mechanism of Action | BPC-157 modulates the nitric oxide system, promotes angiogenesis (new blood vessel formation), and upregulates growth hormone receptors. It also interacts with the dopaminergic system and has been shown to accelerate tendon-to-bone healing by promoting collagen synthesis. | TB-500 is derived from the active region of the full Thymosin Beta-4 protein. It promotes cell migration by binding to and sequestering actin, a protein essential for cell movement. It upregulates actin expression, promotes angiogenesis, reduces inflammation, and facilitates hair follicle stem cell migration for wound healing. |
| Common Dosing | 250-500 mcg twice daily 1-2x daily | 2-2.5 mg twice weekly (loading), then 2.5 mg once weekly (maintenance) 2x weekly for 4-6 weeks, then 1x weekly |
| Administration | Subcutaneous injection near injury site, or systemic | Subcutaneous or intramuscular injection |
| Typical Duration | 4-12 weeks in most research protocols | 4-6 weeks loading, then maintenance |
| Best Time to Take | Morning and evening (or near injury site timing) | Morning or evening |
Possible Side Effects May vary by individual |
|
|
| Research Summary | Extensive preclinical studies demonstrate efficacy in healing tendons, ligaments, muscles, and the GI tract. Animal studies show acceleration of wound healing, protection against NSAID-induced gut damage, and neuroprotective effects. Limited human clinical trials exist. | Research shows significant wound healing acceleration, cardiac tissue repair after heart attack in animal models, and anti-inflammatory effects. Studies demonstrate improved recovery from dermal wounds and muscle injuries. Human clinical trials ongoing for wound healing applications. |
Frequently Asked Questions: BPC-157 vs TB-500
What is the difference between BPC-157 and TB-500?
BPC-157 is a healing peptide that a synthetic peptide derived from a protein found in human gastric juice. known for its remarkable tissue healing properties across multiple body systems. TB-500 is a healing peptide that a synthetic 17-amino acid fragment of thymosin beta-4 (tb-4). not the same as tb-4 - tb-500 has a longer half-life (~2-4 days vs ~2 hours) and is the active region responsible for tissue repair and cell migration. note: many vendors mislabel tb-4 as 'tb-500' in premixed products. The main differences lie in their mechanisms of action and clinical applications.
Which is better, BPC-157 or TB-500?
Neither is universally "better" - the choice depends on your specific goals. BPC-157 is typically used for healing purposes, while TB-500 is used for healing. Always consult with a healthcare provider to determine which may be appropriate for your situation.
Can BPC-157 and TB-500 be used together?
Some peptide protocols combine multiple compounds for synergistic effects. However, using BPC-157 and TB-500 together should only be considered under medical supervision, as both compounds have their own side effect profiles and potential interactions. Research on their combined use may be limited.
Related Comparisons
View Full Peptide Profiles
Educational Information Only
This comparison of BPC-157 and TB-500 is for educational purposes only. Neither this comparison nor any information on this site constitutes medical advice. Always consult with qualified healthcare providers before making decisions about peptides or other substances.