MK-677 vs Sermorelin
Comprehensive side-by-side comparison of mechanisms, dosing, side effects, and research
Also: Ibutamoren, Nutrobal
An orally active growth hormone secretagogue that mimics ghrelin. Not a peptide technically, but frequently discussed alongside GH peptides due to similar effects.
Also: Geref, GRF 1-29
A truncated analog of natural GHRH containing the first 29 amino acids. Previously FDA-approved for pediatric GH deficiency, now used off-label for adult hormone optimization.
Key Comparison Insights
- Both peptides belong to the Growth Hormone category, suggesting similar primary applications.
- MK-677 has stronger research evidence (Human Trials) compared to Sermorelin (Animal Studies).
Detailed Comparison
| Attribute | MK-677 | Sermorelin |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| FDA Status | Not FDA Approved | Not FDA Approved |
| Clinical Status | Pre I II III IV FDA | Pre I II III IV FDA |
| Mechanism of Action | MK-677 binds to ghrelin receptors (GHSR) in the brain, stimulating sustained GH release and increasing IGF-1 levels. Unlike injectable GHRPs, it's orally bioavailable and has a long half-life providing 24-hour GH elevation. | Sermorelin is bioidentical to the active portion of endogenous GHRH. It stimulates the pituitary's natural production and release of growth hormone, maintaining normal feedback mechanisms and pulsatile GH release patterns. |
| Common Dosing | 10-25 mg daily Once daily, often before bed | 200-500 mcg before bed Once daily, typically before bed |
| Administration | Oral | Subcutaneous injection at bedtime |
| Typical Duration | 8-12 weeks or longer | 3-6 months typical |
| Best Time to Take | Before bed | Before bed (fasted) |
Possible Side Effects May vary by individual |
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| Research Summary | Studies show significant increases in GH and IGF-1 levels, improved sleep quality, and increased lean body mass. Research in elderly shows reversal of diet-induced nitrogen wasting. Long-term studies demonstrate sustained efficacy. | Extensive clinical research from FDA approval process. Studies demonstrate restoration of youthful GH levels, improved sleep quality, increased lean body mass, and enhanced recovery. Generally preserves natural GH axis better than exogenous GH. |
Frequently Asked Questions: MK-677 vs Sermorelin
What is the difference between MK-677 and Sermorelin?
MK-677 is a growth hormone peptide that an orally active growth hormone secretagogue that mimics ghrelin. not a peptide technically, but frequently discussed alongside gh peptides due to similar effects. Sermorelin is a growth hormone peptide that a truncated analog of natural ghrh containing the first 29 amino acids. previously fda-approved for pediatric gh deficiency, now used off-label for adult hormone optimization. The main differences lie in their mechanisms of action and clinical applications.
Which is better, MK-677 or Sermorelin?
Neither is universally "better" - the choice depends on your specific goals. MK-677 is typically used for growth hormone purposes, while Sermorelin is used for growth hormone. Always consult with a healthcare provider to determine which may be appropriate for your situation.
Can MK-677 and Sermorelin be used together?
Some peptide protocols combine multiple compounds for synergistic effects. However, using MK-677 and Sermorelin together should only be considered under medical supervision, as both compounds have their own side effect profiles and potential interactions. Research on their combined use may be limited.
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Educational Information Only
This comparison of MK-677 and Sermorelin is for educational purposes only. Neither this comparison nor any information on this site constitutes medical advice. Always consult with qualified healthcare providers before making decisions about peptides or other substances.