Ipamorelin vs Sermorelin
Comprehensive side-by-side comparison of mechanisms, dosing, side effects, and research
Also: IPAM, NNC 26-0161
A selective growth hormone secretagogue that stimulates GH release without significantly affecting cortisol or prolactin. Considered one of the safest GHRPs.
Also: Geref, GRF 1-29
A truncated analog of natural GHRH containing the first 29 amino acids. Previously FDA-approved for pediatric GH deficiency, now used off-label for adult hormone optimization.
Key Comparison Insights
- Both peptides belong to the Growth Hormone category, suggesting similar primary applications.
- Ipamorelin has stronger research evidence (Human Trials) compared to Sermorelin (Animal Studies).
Detailed Comparison
| Attribute | Ipamorelin | Sermorelin |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| FDA Status | Not FDA Approved | Not FDA Approved |
| Clinical Status | Pre I II III IV FDA | Pre I II III IV FDA |
| Mechanism of Action | Ipamorelin binds to ghrelin receptors (GHSR) in the pituitary gland, triggering growth hormone release. Unlike other GHRPs, it does not stimulate significant ACTH, cortisol, prolactin, or aldosterone release, making it highly selective for GH. | Sermorelin is bioidentical to the active portion of endogenous GHRH. It stimulates the pituitary's natural production and release of growth hormone, maintaining normal feedback mechanisms and pulsatile GH release patterns. |
| Common Dosing | 200-300 mcg 2-3x daily 2-3x daily | 200-500 mcg before bed Once daily, typically before bed |
| Administration | Subcutaneous injection | Subcutaneous injection at bedtime |
| Typical Duration | 8-12 weeks typical | 3-6 months typical |
| Best Time to Take | Before bed or morning (fasted) | Before bed (fasted) |
Possible Side Effects May vary by individual |
|
|
| Research Summary | Clinical studies show dose-dependent GH release with minimal side effects. Research demonstrates improved bone density in postmenopausal women and potential benefits for muscle mass and recovery. Has been studied for post-surgical recovery. | Extensive clinical research from FDA approval process. Studies demonstrate restoration of youthful GH levels, improved sleep quality, increased lean body mass, and enhanced recovery. Generally preserves natural GH axis better than exogenous GH. |
Frequently Asked Questions: Ipamorelin vs Sermorelin
What is the difference between Ipamorelin and Sermorelin?
Ipamorelin is a growth hormone peptide that a selective growth hormone secretagogue that stimulates gh release without significantly affecting cortisol or prolactin. considered one of the safest ghrps. Sermorelin is a growth hormone peptide that a truncated analog of natural ghrh containing the first 29 amino acids. previously fda-approved for pediatric gh deficiency, now used off-label for adult hormone optimization. The main differences lie in their mechanisms of action and clinical applications.
Which is better, Ipamorelin or Sermorelin?
Neither is universally "better" - the choice depends on your specific goals. Ipamorelin is typically used for growth hormone purposes, while Sermorelin is used for growth hormone. Always consult with a healthcare provider to determine which may be appropriate for your situation.
Can Ipamorelin and Sermorelin be used together?
Some peptide protocols combine multiple compounds for synergistic effects. However, using Ipamorelin and Sermorelin together should only be considered under medical supervision, as both compounds have their own side effect profiles and potential interactions. Research on their combined use may be limited.
Related Comparisons
View Full Peptide Profiles
Educational Information Only
This comparison of Ipamorelin and Sermorelin is for educational purposes only. Neither this comparison nor any information on this site constitutes medical advice. Always consult with qualified healthcare providers before making decisions about peptides or other substances.