MK-677 vs GHRP-6
Comprehensive side-by-side comparison of mechanisms, dosing, side effects, and research
Also: Ibutamoren, Nutrobal
An orally active growth hormone secretagogue that mimics ghrelin. Not a peptide technically, but frequently discussed alongside GH peptides due to similar effects.
Also: Growth Hormone Releasing Peptide 6, SKF-110679
One of the first synthetic GH secretagogues developed. Strongly stimulates GH release and significantly increases appetite through ghrelin receptor activation.
Key Comparison Insights
- Both peptides belong to the Growth Hormone category, suggesting similar primary applications.
Detailed Comparison
| Attribute | MK-677 | GHRP-6 |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| FDA Status | Not FDA Approved | Not FDA Approved |
| Clinical Status | Pre I II III IV FDA | Pre I II III IV FDA |
| Mechanism of Action | MK-677 binds to ghrelin receptors (GHSR) in the brain, stimulating sustained GH release and increasing IGF-1 levels. Unlike injectable GHRPs, it's orally bioavailable and has a long half-life providing 24-hour GH elevation. | GHRP-6 binds to ghrelin receptors (GHSR-1a) in the hypothalamus and pituitary, triggering a strong GH release. It also activates the hunger-signaling pathway, leading to significant appetite increase. Stimulates cortisol and prolactin more than newer GHRPs. |
| Common Dosing | 10-25 mg daily Once daily, often before bed | 100-300 mcg 2-3x daily 2-3x daily |
| Administration | Oral | Subcutaneous injection, ideally fasted |
| Typical Duration | 8-12 weeks or longer | 8-12 weeks |
| Best Time to Take | Before bed | Before bed or morning (fasted) |
Possible Side Effects May vary by individual |
|
|
| Research Summary | Studies show significant increases in GH and IGF-1 levels, improved sleep quality, and increased lean body mass. Research in elderly shows reversal of diet-induced nitrogen wasting. Long-term studies demonstrate sustained efficacy. | Well-studied peptide showing reliable GH release. Research demonstrates cardioprotective effects in animal models, improved wound healing, and significant appetite stimulation. Studies show 3-6 fold increase in GH levels. |
Frequently Asked Questions: MK-677 vs GHRP-6
What is the difference between MK-677 and GHRP-6?
MK-677 is a growth hormone peptide that an orally active growth hormone secretagogue that mimics ghrelin. not a peptide technically, but frequently discussed alongside gh peptides due to similar effects. GHRP-6 is a growth hormone peptide that one of the first synthetic gh secretagogues developed. strongly stimulates gh release and significantly increases appetite through ghrelin receptor activation. The main differences lie in their mechanisms of action and clinical applications.
Which is better, MK-677 or GHRP-6?
Neither is universally "better" - the choice depends on your specific goals. MK-677 is typically used for growth hormone purposes, while GHRP-6 is used for growth hormone. Always consult with a healthcare provider to determine which may be appropriate for your situation.
Can MK-677 and GHRP-6 be used together?
Some peptide protocols combine multiple compounds for synergistic effects. However, using MK-677 and GHRP-6 together should only be considered under medical supervision, as both compounds have their own side effect profiles and potential interactions. Research on their combined use may be limited.
Related Comparisons
View Full Peptide Profiles
Educational Information Only
This comparison of MK-677 and GHRP-6 is for educational purposes only. Neither this comparison nor any information on this site constitutes medical advice. Always consult with qualified healthcare providers before making decisions about peptides or other substances.